eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining

Translation initiation defines the identity and quantity of a synthesized protein. The process is dysregulated in many human diseases 1 , 2 . A key commitment step is when the ribosomal subunits join at a translation start site on a messenger RNA to form a functional ribosome. Here, we combined sing...

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Veröffentlicht in:	Nature (London) 2022-07, Vol.607 (7917), p.185-190
Hauptverfasser:	Lapointe, Christopher P., Grosely, Rosslyn, Sokabe, Masaaki, Alvarado, Carlos, Wang, Jinfan, Montabana, Elizabeth, Villa, Nancy, Shin, Byung-Sik, Dever, Thomas E., Fraser, Christopher S., Fernández, Israel S., Puglisi, Joseph D.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 38/35 38/71 631/337/574/1789 631/45/500 631/535/1258/1259 631/57/2265 82/80 82/83 Cryoelectron Microscopy Electron microscopy Eukaryotic Initiation Factor-1 - metabolism Eukaryotic Initiation Factors - genetics Humanities and Social Sciences Humans In vitro methods and tests Initiation complex Initiation factors Initiators Microscopy mRNA multidisciplinary Protein synthesis Proteins Ribosomal subunits Ribosome Subunits - chemistry Ribosome Subunits - metabolism RNA, Transfer, Met - genetics RNA, Transfer, Met - metabolism Science Science (multidisciplinary) Single Molecule Imaging Spectroscopy Spectrum analysis Transfer RNA Translation initiation tRNA
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