Direct formation and site-selective elaboration of methionine sulfoximine in polypeptides

Sulfoximines are emerging moieties for medicinal and biological chemistry, due in part to their efficacy in selective inhibition of amide-forming enzymes such as γ-glutamylcysteine synthetase. While small-molecule sulfoximines such as methionine sulfoximine (MSO) and its derivatives are well studied...

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Veröffentlicht in:	Chemical science (Cambridge) 2022-12, Vol.13 (47), p.1411-1415
Hauptverfasser:	Ding, Yuxuan, Pedersen, Simon S, Lin, Alex, Qian, Ruoyu, Ball, Zachary T
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Cross coupling Methionine Oxidation Polypeptides Reagents Residues
Online-Zugang:	Volltext
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