Structure of Tetrahymena telomerase-bound CST with polymerase α-primase

Telomeres are the physical ends of linear chromosomes. They are composed of short repeating sequences (such as TTGGGG in the G-strand for Tetrahymena thermophila ) of double-stranded DNA with a single-strand 3′ overhang of the G-strand and, in humans, the six shelterin proteins: TPP1, POT1, TRF1, TR...

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Veröffentlicht in:	Nature (London) 2022-08, Vol.608 (7924), p.813-818
Hauptverfasser:	He, Yao, Song, He, Chan, Henry, Liu, Baocheng, Wang, Yaqiang, Sušac, Lukas, Zhou, Z. Hong, Feigon, Juli
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 38/22 38/71 38/77 631/337/151/1431 631/45/535/1258/1259 631/45/535/878/1263 631/45/607/1167 631/45/612/1229 82/16 82/29 82/6 82/80 82/83 Binding Chromosomes Cryoelectron Microscopy Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA biosynthesis DNA polymerase DNA Primase - chemistry DNA Primase - metabolism DNA Primase - ultrastructure DNA-directed DNA polymerase Electron microscopy Genomes Holoenzymes - chemistry Holoenzymes - metabolism Holoenzymes - ultrastructure Humanities and Social Sciences Interfaces Magnetic resonance spectroscopy multidisciplinary NMR NMR spectroscopy Nuclear magnetic resonance Peptides Primase Protein Binding Proteins Rap1 protein Recruitment Science Science (multidisciplinary) Shelterin Complex - chemistry Shelterin Complex - metabolism Shelterin Complex - ultrastructure Spectroscopy Spectrum analysis Synthesis Telomerase Telomerase - chemistry Telomerase - metabolism Telomerase - ultrastructure Telomere - genetics Telomere - metabolism Telomere-binding protein Telomeres Tetrahymena Tetrahymena - chemistry Tetrahymena - enzymology Tetrahymena - metabolism Tetrahymena - ultrastructure TRF2 protein
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