Molecular characterization of a toxicological tipping point during human stem cell differentiation

[Display omitted] •All-trans retinoic acid (ATRA) >17 nM (tipping point) shifted the differentiation trajectory of human induced pluripotent stem cells (hiPSCs).•ATRA concentrations above 10 nM significantly reduced FOXA2 protein expression.•ATRA above the tipping point impacted expression of gen...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2020-01, Vol.91, p.1-13
Hauptverfasser:	Saili, Katerine S., Antonijevic, Todor, Zurlinden, Todd J., Shah, Imran, Deisenroth, Chad, Knudsen, Thomas B.
Format:	Artikel
Sprache:	eng
Schlagworte:	All-trans retinoic acid Cell Differentiation Cell Line Differentiation Endoderm EOMES FOXA2 Gene Expression Regulation, Developmental - drug effects Humans Induced Pluripotent Stem Cells - drug effects iPSC SOX17 Teratogens - toxicity Tipping point Tretinoin - toxicity
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