YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation

Background LncRNA FGF14-AS2 is a critical suppressor in breast cancer (BCa) metastasis. However, whether FGF14-AS2 plays a role in the bone metastasis of BCa remains unknown. Methods TRAP assay and intratibial injection were carried out to evaluate the role of FGF14-AS2 in BCa bone metastasis in vit...

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Veröffentlicht in:	British journal of cancer 2022-12, Vol.127 (12), p.2141-2153
Hauptverfasser:	Zhang, Ming, Wang, Jue, Jin, Yucui, Zheng, Que, Xing, Mengying, Tang, Yuting, Ma, Yunfei, Li, Lingyun, Yao, Bing, Wu, Hao, Ma, Changyan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/176/2016 631/67/1347 631/67/322/803 631/67/68/2486 692/53/2421 Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Cancer Research Cbfa-1 protein Core Binding Factor Alpha 1 Subunit - genetics Drug Resistance Epidemiology Female Humans Initiation factor eIF-4E Initiation factor eIF-4G Metastases Metastasis Molecular Medicine N6-methyladenosine Non-coding RNA Oncology Osteoclastogenesis Osteolysis Phosphorylation Protein Biosynthesis RNA, Long Noncoding - genetics RNA-Binding Proteins - genetics Therapeutic targets
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