Kawasaki Disease Following the 13-valent Pneumococcal Conjugate Vaccine and Rotavirus Vaccines
Temporal associations between Kawasaki disease (KD) and childhood vaccines have been reported. Limited data on KD following 13-valent pneumococcal conjugate (PCV13) and rotavirus vaccines are available. We conducted a self-controlled risk interval study using Vaccine Safety Datalink electronic healt...
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| Veröffentlicht in: | Pediatrics (Evanston) 2022-12, Vol.150 (6), p.1 |
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| creator | Kamidani, Satoshi Panagiotakopoulos, Lakshmi Licata, Charles Daley, Matthew F Yih, W Katherine Zerbo, Ousseny Tseng, Hung Fu DeSilva, Malini B Nelson, Jennifer C Groom, Holly C Williams, Joshua T B Hambidge, Simon J Donahue, James G Belay, Ermias D Weintraub, Eric S |
| description | Temporal associations between Kawasaki disease (KD) and childhood vaccines have been reported. Limited data on KD following 13-valent pneumococcal conjugate (PCV13) and rotavirus vaccines are available.
We conducted a self-controlled risk interval study using Vaccine Safety Datalink electronic health record data to investigate the risk of KD following PCV13 and rotavirus vaccines in children |
| doi_str_mv | 10.1542/peds.2022-058789 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9724171</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2746489876</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-98c60bbc69f86133f2a9c7faadb3134198ddaa9ec3e8e94434149b7dc2db56e33</originalsourceid><addsrcrecordid>eNpVkUtLw0AUhQdRbK3uXcmA69R5JTOzEaQ-saCIunS4mUza1DRTM0nFf29KH-jqwr3nnHvgQ-iUkiGNBbtYuCwMGWEsIrGSSu-hPiVaRYLJeB_1CeE0EoTEPXQUwowQImLJDlGPJ1zomMs--niEbwjwWeDrIjgIDt_6svTfRTXBzdRhyqMllK5q8HPl2rm33loo8chXs3YCjcPvYG1ROQxVhl98A8uibsN2G47RQQ5lcCebOUBvtzevo_to_HT3MLoaR5Yr1kRa2YSkqU10rhLKec5AW5kDZCmnXFCtsgxAO8udclqIbiV0KjPLsjROHOcDdLnOXbTp3GW2K1xDaRZ1MYf6x3gozP9LVUzNxC-NlkxQSbuA801A7b9aFxoz821ddZ0NkyIRSiuZdCqyVtnah1C7fPeBErMiYlZEzIqIWRPpLGd_m-0MWwT8F9BSiZw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2746489876</pqid></control><display><type>article</type><title>Kawasaki Disease Following the 13-valent Pneumococcal Conjugate Vaccine and Rotavirus Vaccines</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Kamidani, Satoshi ; Panagiotakopoulos, Lakshmi ; Licata, Charles ; Daley, Matthew F ; Yih, W Katherine ; Zerbo, Ousseny ; Tseng, Hung Fu ; DeSilva, Malini B ; Nelson, Jennifer C ; Groom, Holly C ; Williams, Joshua T B ; Hambidge, Simon J ; Donahue, James G ; Belay, Ermias D ; Weintraub, Eric S</creator><creatorcontrib>Kamidani, Satoshi ; Panagiotakopoulos, Lakshmi ; Licata, Charles ; Daley, Matthew F ; Yih, W Katherine ; Zerbo, Ousseny ; Tseng, Hung Fu ; DeSilva, Malini B ; Nelson, Jennifer C ; Groom, Holly C ; Williams, Joshua T B ; Hambidge, Simon J ; Donahue, James G ; Belay, Ermias D ; Weintraub, Eric S</creatorcontrib><description>Temporal associations between Kawasaki disease (KD) and childhood vaccines have been reported. Limited data on KD following 13-valent pneumococcal conjugate (PCV13) and rotavirus vaccines are available.
We conducted a self-controlled risk interval study using Vaccine Safety Datalink electronic health record data to investigate the risk of KD following PCV13 and rotavirus vaccines in children <2 years of age who were born from 2006 to 2017. All hospitalized KD cases identified by International Classification of Diseases diagnosis codes that fell within predefined risk (days 1-28 postvaccination) and control (days 29-56 for doses 1 and 2, and days 43-70 for doses 3 and 4) intervals were confirmed by manual chart review.
During the study period, 655 cases of KD were identified by International Classification of Diseases codes. Of these, 97 chart-confirmed cases were within risk or control intervals. In analyses, the age-adjusted relative risk for KD following any dose of PCV13 was 0.75 (95% confidence interval, 0.47-1.21). Similarly, the age-adjusted relative risk for KD following any dose of rotavirus vaccine was 0.66 (95% CI, 0.40-1.09). Overall, there was no evidence of an elevated risk of KD following PCV13 or rotavirus vaccines by dose. In addition, no statistically significant temporal clustering of KD cases was identified during days 1 to 70 postvaccination.
PCV13 and rotavirus vaccination were not associated with an increased risk of KD in children <2 years of age. Our findings provide additional evidence for the overall safety of PCV13 and rotavirus vaccines.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2022-058789</identifier><identifier>PMID: 36349537</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Children ; Classification ; Electronic medical records ; Humans ; Infant ; Kawasaki disease ; Mucocutaneous lymph node syndrome ; Mucocutaneous Lymph Node Syndrome - epidemiology ; Mucocutaneous Lymph Node Syndrome - etiology ; Pediatrics ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - adverse effects ; Rotavirus ; Rotavirus Vaccines - adverse effects ; Statistical analysis ; Vaccination - adverse effects ; Vaccines ; Vaccines, Conjugate - adverse effects ; Viruses</subject><ispartof>Pediatrics (Evanston), 2022-12, Vol.150 (6), p.1</ispartof><rights>Copyright © 2022 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Dec 2022</rights><rights>Copyright © 2022 by the American Academy of Pediatrics 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-98c60bbc69f86133f2a9c7faadb3134198ddaa9ec3e8e94434149b7dc2db56e33</citedby><cites>FETCH-LOGICAL-c382t-98c60bbc69f86133f2a9c7faadb3134198ddaa9ec3e8e94434149b7dc2db56e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36349537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamidani, Satoshi</creatorcontrib><creatorcontrib>Panagiotakopoulos, Lakshmi</creatorcontrib><creatorcontrib>Licata, Charles</creatorcontrib><creatorcontrib>Daley, Matthew F</creatorcontrib><creatorcontrib>Yih, W Katherine</creatorcontrib><creatorcontrib>Zerbo, Ousseny</creatorcontrib><creatorcontrib>Tseng, Hung Fu</creatorcontrib><creatorcontrib>DeSilva, Malini B</creatorcontrib><creatorcontrib>Nelson, Jennifer C</creatorcontrib><creatorcontrib>Groom, Holly C</creatorcontrib><creatorcontrib>Williams, Joshua T B</creatorcontrib><creatorcontrib>Hambidge, Simon J</creatorcontrib><creatorcontrib>Donahue, James G</creatorcontrib><creatorcontrib>Belay, Ermias D</creatorcontrib><creatorcontrib>Weintraub, Eric S</creatorcontrib><title>Kawasaki Disease Following the 13-valent Pneumococcal Conjugate Vaccine and Rotavirus Vaccines</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Temporal associations between Kawasaki disease (KD) and childhood vaccines have been reported. Limited data on KD following 13-valent pneumococcal conjugate (PCV13) and rotavirus vaccines are available.
We conducted a self-controlled risk interval study using Vaccine Safety Datalink electronic health record data to investigate the risk of KD following PCV13 and rotavirus vaccines in children <2 years of age who were born from 2006 to 2017. All hospitalized KD cases identified by International Classification of Diseases diagnosis codes that fell within predefined risk (days 1-28 postvaccination) and control (days 29-56 for doses 1 and 2, and days 43-70 for doses 3 and 4) intervals were confirmed by manual chart review.
During the study period, 655 cases of KD were identified by International Classification of Diseases codes. Of these, 97 chart-confirmed cases were within risk or control intervals. In analyses, the age-adjusted relative risk for KD following any dose of PCV13 was 0.75 (95% confidence interval, 0.47-1.21). Similarly, the age-adjusted relative risk for KD following any dose of rotavirus vaccine was 0.66 (95% CI, 0.40-1.09). Overall, there was no evidence of an elevated risk of KD following PCV13 or rotavirus vaccines by dose. In addition, no statistically significant temporal clustering of KD cases was identified during days 1 to 70 postvaccination.
PCV13 and rotavirus vaccination were not associated with an increased risk of KD in children <2 years of age. Our findings provide additional evidence for the overall safety of PCV13 and rotavirus vaccines.</description><subject>Children</subject><subject>Classification</subject><subject>Electronic medical records</subject><subject>Humans</subject><subject>Infant</subject><subject>Kawasaki disease</subject><subject>Mucocutaneous lymph node syndrome</subject><subject>Mucocutaneous Lymph Node Syndrome - epidemiology</subject><subject>Mucocutaneous Lymph Node Syndrome - etiology</subject><subject>Pediatrics</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines - adverse effects</subject><subject>Rotavirus</subject><subject>Rotavirus Vaccines - adverse effects</subject><subject>Statistical analysis</subject><subject>Vaccination - adverse effects</subject><subject>Vaccines</subject><subject>Vaccines, Conjugate - adverse effects</subject><subject>Viruses</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLw0AUhQdRbK3uXcmA69R5JTOzEaQ-saCIunS4mUza1DRTM0nFf29KH-jqwr3nnHvgQ-iUkiGNBbtYuCwMGWEsIrGSSu-hPiVaRYLJeB_1CeE0EoTEPXQUwowQImLJDlGPJ1zomMs--niEbwjwWeDrIjgIDt_6svTfRTXBzdRhyqMllK5q8HPl2rm33loo8chXs3YCjcPvYG1ROQxVhl98A8uibsN2G47RQQ5lcCebOUBvtzevo_to_HT3MLoaR5Yr1kRa2YSkqU10rhLKec5AW5kDZCmnXFCtsgxAO8udclqIbiV0KjPLsjROHOcDdLnOXbTp3GW2K1xDaRZ1MYf6x3gozP9LVUzNxC-NlkxQSbuA801A7b9aFxoz821ddZ0NkyIRSiuZdCqyVtnah1C7fPeBErMiYlZEzIqIWRPpLGd_m-0MWwT8F9BSiZw</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Kamidani, Satoshi</creator><creator>Panagiotakopoulos, Lakshmi</creator><creator>Licata, Charles</creator><creator>Daley, Matthew F</creator><creator>Yih, W Katherine</creator><creator>Zerbo, Ousseny</creator><creator>Tseng, Hung Fu</creator><creator>DeSilva, Malini B</creator><creator>Nelson, Jennifer C</creator><creator>Groom, Holly C</creator><creator>Williams, Joshua T B</creator><creator>Hambidge, Simon J</creator><creator>Donahue, James G</creator><creator>Belay, Ermias D</creator><creator>Weintraub, Eric S</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>5PM</scope></search><sort><creationdate>20221201</creationdate><title>Kawasaki Disease Following the 13-valent Pneumococcal Conjugate Vaccine and Rotavirus Vaccines</title><author>Kamidani, Satoshi ; Panagiotakopoulos, Lakshmi ; Licata, Charles ; Daley, Matthew F ; Yih, W Katherine ; Zerbo, Ousseny ; Tseng, Hung Fu ; DeSilva, Malini B ; Nelson, Jennifer C ; Groom, Holly C ; Williams, Joshua T B ; Hambidge, Simon J ; Donahue, James G ; Belay, Ermias D ; Weintraub, Eric S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-98c60bbc69f86133f2a9c7faadb3134198ddaa9ec3e8e94434149b7dc2db56e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Children</topic><topic>Classification</topic><topic>Electronic medical records</topic><topic>Humans</topic><topic>Infant</topic><topic>Kawasaki disease</topic><topic>Mucocutaneous lymph node syndrome</topic><topic>Mucocutaneous Lymph Node Syndrome - epidemiology</topic><topic>Mucocutaneous Lymph Node Syndrome - etiology</topic><topic>Pediatrics</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal Vaccines - adverse effects</topic><topic>Rotavirus</topic><topic>Rotavirus Vaccines - adverse effects</topic><topic>Statistical analysis</topic><topic>Vaccination - adverse effects</topic><topic>Vaccines</topic><topic>Vaccines, Conjugate - adverse effects</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamidani, Satoshi</creatorcontrib><creatorcontrib>Panagiotakopoulos, Lakshmi</creatorcontrib><creatorcontrib>Licata, Charles</creatorcontrib><creatorcontrib>Daley, Matthew F</creatorcontrib><creatorcontrib>Yih, W Katherine</creatorcontrib><creatorcontrib>Zerbo, Ousseny</creatorcontrib><creatorcontrib>Tseng, Hung Fu</creatorcontrib><creatorcontrib>DeSilva, Malini B</creatorcontrib><creatorcontrib>Nelson, Jennifer C</creatorcontrib><creatorcontrib>Groom, Holly C</creatorcontrib><creatorcontrib>Williams, Joshua T B</creatorcontrib><creatorcontrib>Hambidge, Simon J</creatorcontrib><creatorcontrib>Donahue, James G</creatorcontrib><creatorcontrib>Belay, Ermias D</creatorcontrib><creatorcontrib>Weintraub, Eric S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamidani, Satoshi</au><au>Panagiotakopoulos, Lakshmi</au><au>Licata, Charles</au><au>Daley, Matthew F</au><au>Yih, W Katherine</au><au>Zerbo, Ousseny</au><au>Tseng, Hung Fu</au><au>DeSilva, Malini B</au><au>Nelson, Jennifer C</au><au>Groom, Holly C</au><au>Williams, Joshua T B</au><au>Hambidge, Simon J</au><au>Donahue, James G</au><au>Belay, Ermias D</au><au>Weintraub, Eric S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kawasaki Disease Following the 13-valent Pneumococcal Conjugate Vaccine and Rotavirus Vaccines</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>150</volume><issue>6</issue><spage>1</spage><pages>1-</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Temporal associations between Kawasaki disease (KD) and childhood vaccines have been reported. Limited data on KD following 13-valent pneumococcal conjugate (PCV13) and rotavirus vaccines are available.
We conducted a self-controlled risk interval study using Vaccine Safety Datalink electronic health record data to investigate the risk of KD following PCV13 and rotavirus vaccines in children <2 years of age who were born from 2006 to 2017. All hospitalized KD cases identified by International Classification of Diseases diagnosis codes that fell within predefined risk (days 1-28 postvaccination) and control (days 29-56 for doses 1 and 2, and days 43-70 for doses 3 and 4) intervals were confirmed by manual chart review.
During the study period, 655 cases of KD were identified by International Classification of Diseases codes. Of these, 97 chart-confirmed cases were within risk or control intervals. In analyses, the age-adjusted relative risk for KD following any dose of PCV13 was 0.75 (95% confidence interval, 0.47-1.21). Similarly, the age-adjusted relative risk for KD following any dose of rotavirus vaccine was 0.66 (95% CI, 0.40-1.09). Overall, there was no evidence of an elevated risk of KD following PCV13 or rotavirus vaccines by dose. In addition, no statistically significant temporal clustering of KD cases was identified during days 1 to 70 postvaccination.
PCV13 and rotavirus vaccination were not associated with an increased risk of KD in children <2 years of age. Our findings provide additional evidence for the overall safety of PCV13 and rotavirus vaccines.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>36349537</pmid><doi>10.1542/peds.2022-058789</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Children Classification Electronic medical records Humans Infant Kawasaki disease Mucocutaneous lymph node syndrome Mucocutaneous Lymph Node Syndrome - epidemiology Mucocutaneous Lymph Node Syndrome - etiology Pediatrics Pneumococcal Infections - prevention & control Pneumococcal Vaccines - adverse effects Rotavirus Rotavirus Vaccines - adverse effects Statistical analysis Vaccination - adverse effects Vaccines Vaccines, Conjugate - adverse effects Viruses |
| title | Kawasaki Disease Following the 13-valent Pneumococcal Conjugate Vaccine and Rotavirus Vaccines |
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