Protective Effects of Estrogen via Nanoparticle Delivery to Attenuate Myelin Loss and Neuronal Death after Spinal Cord Injury

Spinal cord injury (SCI) is associated with devastating neurological deficits affecting more than 11,000 Americans each year. Although several therapeutic agents have been proposed and tested, no FDA-approved pharmacotherapy is available for SCI treatment. We have recently demonstrated that estrogen...

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Veröffentlicht in:	Neurochemical research 2021-11, Vol.46 (11), p.2979-2990
Hauptverfasser:	Haque, Azizul, Drasites, Kelsey P., Cox, April, Capone, Mollie, Myatich, Ali I., Shams, Ramsha, Matzelle, Denise, Garner, Dena P., Bredikhin, Mikhail, Shields, Donald C., Vertegel, Alexey, Banik, Naren L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Antioxidants Astrocytes Attenuation Biochemistry Biomedical and Life Sciences Biomedicine Calpain Cell Biology Cell death Cell Death - drug effects Cell Death - physiology Chemical compounds Demyelination Drug Delivery Systems - methods Drug therapy Estrogens Estrogens - administration & dosage Fibroblasts Glial cells Gliosis Humans Inflammation Injury prevention Lesions Macrophages Male Mice Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Myelin Myelin Sheath - drug effects Myelin Sheath - metabolism Myelin Sheath - pathology Nanoparticles Nanoparticles - administration & dosage Neurochemistry Neurological diseases Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - administration & dosage Neurosciences Original Paper Pharmacology Rats Rats, Sprague-Dawley RAW 264.7 Cells Reactive oxygen species Spinal cord injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Thoracic Vertebrae - injuries
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