Exercise plasma boosts memory and dampens brain inflammation via clusterin

Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration 1 . The cognitive benefits of physical exercise are tied to an increased plasticity and reduced inflammation within the hippocampus 2 – 4 , yet little is known about th...

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Veröffentlicht in:	Nature (London) 2021-12, Vol.600 (7889), p.494-499
Hauptverfasser:	De Miguel, Zurine, Khoury, Nathalie, Betley, Michael J., Lehallier, Benoit, Willoughby, Drew, Olsson, Niclas, Yang, Andrew C., Hahn, Oliver, Lu, Nannan, Vest, Ryan T., Bonanno, Liana N., Yerra, Lakshmi, Zhang, Lichao, Saw, Nay Lui, Fairchild, J. Kaci, Lee, Davis, Zhang, Hui, McAlpine, Patrick L., Contrepois, Kévin, Shamloo, Mehrdad, Elias, Joshua E., Rando, Thomas A., Wyss-Coray, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 101/47 13/51 14/19 45/91 631/378/340 631/378/368/2431 631/378/371 64/60 82/58 Aging Alzheimer Disease - metabolism Alzheimer's disease Animal health Animals Brain Cell growth Clusterin Clusterin - genetics Clusterin - metabolism Cognition & reasoning Cognitive ability Cytokines Encephalitis Endothelial cells Endothelial Cells - metabolism Exercise Gene expression Hippocampal plasticity Humanities and Social Sciences Humans Inflammation Memory Mice multidisciplinary Neurodegenerative diseases Neurogenesis Physical exercise Physical fitness Physical training Plasma Plasma levels Proteins Proteomics Rodents Running Science Science (multidisciplinary)
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