A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales
Studies of COVID-19 vaccine effectiveness show increases in COVID-19 cases within 14 days of a first dose, potentially reflecting post-vaccination behaviour changes associated with SARS-CoV-2 transmission before vaccine protection. However, direct evidence for a relationship between vaccination and...
Gespeichert in:
Veröffentlicht in: | Vaccine 2023-01, Vol.41 (2), p.511-518 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 518 |
---|---|
container_issue | 2 |
container_start_page | 511 |
container_title | Vaccine |
container_volume | 41 |
creator | Serisier, Aimee Beale, Sarah Boukari, Yamina Hoskins, Susan Nguyen, Vincent Byrne, Thomas Fong, Wing Lam Erica Fragaszy, Ellen Geismar, Cyril Kovar, Jana Yavlinsky, Alexei Hayward, Andrew Aldridge, Robert W. |
description | Studies of COVID-19 vaccine effectiveness show increases in COVID-19 cases within 14 days of a first dose, potentially reflecting post-vaccination behaviour changes associated with SARS-CoV-2 transmission before vaccine protection. However, direct evidence for a relationship between vaccination and behaviour is lacking. We aimed to examine the association between vaccination status and self-reported non-household contacts and non-essential activities during a national lockdown in England and Wales.
Participants (n = 1154) who had received the first dose of a COVID-19 vaccine reported non-household contacts and non-essential activities from February to March 2021 in monthly surveys during a national lockdown in England and Wales. We used a case-crossover study design and conditional logistic regression to examine the association between vaccination status (pre-vaccination vs 14 days post-vaccination) and self-reported contacts and activities within individuals. Stratified subgroup analyses examined potential effect heterogeneity by sociodemographic characteristics such as sex, household income or age group.
457/1154 (39.60 %) participants reported non-household contacts post-vaccination compared with 371/1154 (32.15 %) participants pre-vaccination. 100/1154 (8.67 %) participants reported use of non-essential shops or services post-vaccination compared with 74/1154 (6.41 %) participants pre-vaccination. Post-vaccination status was associated with increased odds of reporting non-household contacts (OR 1.65, 95 % CI 1.31–2.06, p |
doi_str_mv | 10.1016/j.vaccine.2022.11.073 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9721283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X22014979</els_id><sourcerecordid>2759702548</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-a31084df67675db4a7c2064ed9e7aaad7e43fae7f32b8e75d82a52829f41f10f3</originalsourceid><addsrcrecordid>eNqFkV2L1DAUhoso7rj6E5SAN9605qtNe6MMw_oBC4Lr113IJCczGTvJbNJW9r_4Y013xkW9ERJCOE_ek_O-RfGU4Ipg0rzcVZPS2nmoKKa0IqTCgt0rFqQVrKQ1ae8XC0wbXnKCv50Vj1LaYYxrRrqHxRlreNfQli6Kn0ukVYJSx5BSmCCiNIzmBgWLhi0gsBb0MN-O3dTggkd5XS0_XpWr8KWkaIjKp71LaS5F6GFSfkBr2KrJhTEmZMbo_AYpdIDogpnVjkKqR33Q30344ZHz6MJveuUNmvdX1UN6XDywqk_w5HSeF5_fXHxavSsvP7x9v1pelpp39VAqRnDLjW1EI2qz5kpoihsOpgOhlDICOLMKhGV03UJGWqrqPH1nObEEW3ZevDrqHsb1HowGn2fq5SG6vYo3Mign_654t5WbMMlOUEJblgVenARiuB4hDTL7oaHP40AYk6SiZgzzumsz-vwfdJdNylbcUp3AtOYzVR-p21wi2LvPECzn_OVOnvKXc_6SEJnzz--e_TnJ3avfgWfg9RGA7OfkIMqkHXgNxsWctDTB_afFL6-qxyk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2759702548</pqid></control><display><type>article</type><title>A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Serisier, Aimee ; Beale, Sarah ; Boukari, Yamina ; Hoskins, Susan ; Nguyen, Vincent ; Byrne, Thomas ; Fong, Wing Lam Erica ; Fragaszy, Ellen ; Geismar, Cyril ; Kovar, Jana ; Yavlinsky, Alexei ; Hayward, Andrew ; Aldridge, Robert W.</creator><creatorcontrib>Serisier, Aimee ; Beale, Sarah ; Boukari, Yamina ; Hoskins, Susan ; Nguyen, Vincent ; Byrne, Thomas ; Fong, Wing Lam Erica ; Fragaszy, Ellen ; Geismar, Cyril ; Kovar, Jana ; Yavlinsky, Alexei ; Hayward, Andrew ; Aldridge, Robert W.</creatorcontrib><description>Studies of COVID-19 vaccine effectiveness show increases in COVID-19 cases within 14 days of a first dose, potentially reflecting post-vaccination behaviour changes associated with SARS-CoV-2 transmission before vaccine protection. However, direct evidence for a relationship between vaccination and behaviour is lacking. We aimed to examine the association between vaccination status and self-reported non-household contacts and non-essential activities during a national lockdown in England and Wales.
Participants (n = 1154) who had received the first dose of a COVID-19 vaccine reported non-household contacts and non-essential activities from February to March 2021 in monthly surveys during a national lockdown in England and Wales. We used a case-crossover study design and conditional logistic regression to examine the association between vaccination status (pre-vaccination vs 14 days post-vaccination) and self-reported contacts and activities within individuals. Stratified subgroup analyses examined potential effect heterogeneity by sociodemographic characteristics such as sex, household income or age group.
457/1154 (39.60 %) participants reported non-household contacts post-vaccination compared with 371/1154 (32.15 %) participants pre-vaccination. 100/1154 (8.67 %) participants reported use of non-essential shops or services post-vaccination compared with 74/1154 (6.41 %) participants pre-vaccination. Post-vaccination status was associated with increased odds of reporting non-household contacts (OR 1.65, 95 % CI 1.31–2.06, p < 0.001) and use of non-essential shops or services (OR 1.50, 95 % CI 1.03–2.17, p = 0.032). This effect varied between men and women and different age groups.
Participants had higher odds of reporting non-household contacts and use of non-essential shops or services within 14 days of their first COVID-19 vaccine compared to pre-vaccination. Public health emphasis on maintaining protective behaviours during this post-vaccination time period when individuals have yet to develop full protection from vaccination could reduce risk of SARS-CoV-2 infection.</description><identifier>ISSN: 0264-410X</identifier><identifier>ISSN: 1873-2518</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2022.11.073</identifier><identifier>PMID: 36496282</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Behaviour ; Case studies ; Communicable Disease Control ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - prevention & control ; COVID-19 Vaccines ; Cross-Over Studies ; England - epidemiology ; Female ; Heterogeneity ; Households ; Humans ; Immunization ; Male ; Mitigations ; Public health ; Risk management ; SARS-CoV-2 ; Self Report ; Severe acute respiratory syndrome coronavirus 2 ; Subgroups ; Vaccination ; Vaccine ; Vaccine efficacy ; Vaccines ; Wales - epidemiology</subject><ispartof>Vaccine, 2023-01, Vol.41 (2), p.511-518</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2022. The Authors</rights><rights>2022 The Authors. Published by Elsevier Ltd. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-a31084df67675db4a7c2064ed9e7aaad7e43fae7f32b8e75d82a52829f41f10f3</citedby><cites>FETCH-LOGICAL-c495t-a31084df67675db4a7c2064ed9e7aaad7e43fae7f32b8e75d82a52829f41f10f3</cites><orcidid>0000-0002-0418-309X ; 0000-0002-4038-7460 ; 0000-0001-6193-9159 ; 0000-0003-0542-0816 ; 0000-0002-9776-6242 ; 0000-0002-3549-6232 ; 0000-0002-8486-5890</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2759702548?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36496282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serisier, Aimee</creatorcontrib><creatorcontrib>Beale, Sarah</creatorcontrib><creatorcontrib>Boukari, Yamina</creatorcontrib><creatorcontrib>Hoskins, Susan</creatorcontrib><creatorcontrib>Nguyen, Vincent</creatorcontrib><creatorcontrib>Byrne, Thomas</creatorcontrib><creatorcontrib>Fong, Wing Lam Erica</creatorcontrib><creatorcontrib>Fragaszy, Ellen</creatorcontrib><creatorcontrib>Geismar, Cyril</creatorcontrib><creatorcontrib>Kovar, Jana</creatorcontrib><creatorcontrib>Yavlinsky, Alexei</creatorcontrib><creatorcontrib>Hayward, Andrew</creatorcontrib><creatorcontrib>Aldridge, Robert W.</creatorcontrib><title>A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Studies of COVID-19 vaccine effectiveness show increases in COVID-19 cases within 14 days of a first dose, potentially reflecting post-vaccination behaviour changes associated with SARS-CoV-2 transmission before vaccine protection. However, direct evidence for a relationship between vaccination and behaviour is lacking. We aimed to examine the association between vaccination status and self-reported non-household contacts and non-essential activities during a national lockdown in England and Wales.
Participants (n = 1154) who had received the first dose of a COVID-19 vaccine reported non-household contacts and non-essential activities from February to March 2021 in monthly surveys during a national lockdown in England and Wales. We used a case-crossover study design and conditional logistic regression to examine the association between vaccination status (pre-vaccination vs 14 days post-vaccination) and self-reported contacts and activities within individuals. Stratified subgroup analyses examined potential effect heterogeneity by sociodemographic characteristics such as sex, household income or age group.
457/1154 (39.60 %) participants reported non-household contacts post-vaccination compared with 371/1154 (32.15 %) participants pre-vaccination. 100/1154 (8.67 %) participants reported use of non-essential shops or services post-vaccination compared with 74/1154 (6.41 %) participants pre-vaccination. Post-vaccination status was associated with increased odds of reporting non-household contacts (OR 1.65, 95 % CI 1.31–2.06, p < 0.001) and use of non-essential shops or services (OR 1.50, 95 % CI 1.03–2.17, p = 0.032). This effect varied between men and women and different age groups.
Participants had higher odds of reporting non-household contacts and use of non-essential shops or services within 14 days of their first COVID-19 vaccine compared to pre-vaccination. Public health emphasis on maintaining protective behaviours during this post-vaccination time period when individuals have yet to develop full protection from vaccination could reduce risk of SARS-CoV-2 infection.</description><subject>Behaviour</subject><subject>Case studies</subject><subject>Communicable Disease Control</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - prevention & control</subject><subject>COVID-19 Vaccines</subject><subject>Cross-Over Studies</subject><subject>England - epidemiology</subject><subject>Female</subject><subject>Heterogeneity</subject><subject>Households</subject><subject>Humans</subject><subject>Immunization</subject><subject>Male</subject><subject>Mitigations</subject><subject>Public health</subject><subject>Risk management</subject><subject>SARS-CoV-2</subject><subject>Self Report</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Subgroups</subject><subject>Vaccination</subject><subject>Vaccine</subject><subject>Vaccine efficacy</subject><subject>Vaccines</subject><subject>Wales - epidemiology</subject><issn>0264-410X</issn><issn>1873-2518</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV2L1DAUhoso7rj6E5SAN9605qtNe6MMw_oBC4Lr113IJCczGTvJbNJW9r_4Y013xkW9ERJCOE_ek_O-RfGU4Ipg0rzcVZPS2nmoKKa0IqTCgt0rFqQVrKQ1ae8XC0wbXnKCv50Vj1LaYYxrRrqHxRlreNfQli6Kn0ukVYJSx5BSmCCiNIzmBgWLhi0gsBb0MN-O3dTggkd5XS0_XpWr8KWkaIjKp71LaS5F6GFSfkBr2KrJhTEmZMbo_AYpdIDogpnVjkKqR33Q30344ZHz6MJveuUNmvdX1UN6XDywqk_w5HSeF5_fXHxavSsvP7x9v1pelpp39VAqRnDLjW1EI2qz5kpoihsOpgOhlDICOLMKhGV03UJGWqrqPH1nObEEW3ZevDrqHsb1HowGn2fq5SG6vYo3Mign_654t5WbMMlOUEJblgVenARiuB4hDTL7oaHP40AYk6SiZgzzumsz-vwfdJdNylbcUp3AtOYzVR-p21wi2LvPECzn_OVOnvKXc_6SEJnzz--e_TnJ3avfgWfg9RGA7OfkIMqkHXgNxsWctDTB_afFL6-qxyk</recordid><startdate>20230109</startdate><enddate>20230109</enddate><creator>Serisier, Aimee</creator><creator>Beale, Sarah</creator><creator>Boukari, Yamina</creator><creator>Hoskins, Susan</creator><creator>Nguyen, Vincent</creator><creator>Byrne, Thomas</creator><creator>Fong, Wing Lam Erica</creator><creator>Fragaszy, Ellen</creator><creator>Geismar, Cyril</creator><creator>Kovar, Jana</creator><creator>Yavlinsky, Alexei</creator><creator>Hayward, Andrew</creator><creator>Aldridge, Robert W.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><general>The Authors. Published by Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0418-309X</orcidid><orcidid>https://orcid.org/0000-0002-4038-7460</orcidid><orcidid>https://orcid.org/0000-0001-6193-9159</orcidid><orcidid>https://orcid.org/0000-0003-0542-0816</orcidid><orcidid>https://orcid.org/0000-0002-9776-6242</orcidid><orcidid>https://orcid.org/0000-0002-3549-6232</orcidid><orcidid>https://orcid.org/0000-0002-8486-5890</orcidid></search><sort><creationdate>20230109</creationdate><title>A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales</title><author>Serisier, Aimee ; Beale, Sarah ; Boukari, Yamina ; Hoskins, Susan ; Nguyen, Vincent ; Byrne, Thomas ; Fong, Wing Lam Erica ; Fragaszy, Ellen ; Geismar, Cyril ; Kovar, Jana ; Yavlinsky, Alexei ; Hayward, Andrew ; Aldridge, Robert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-a31084df67675db4a7c2064ed9e7aaad7e43fae7f32b8e75d82a52829f41f10f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Behaviour</topic><topic>Case studies</topic><topic>Communicable Disease Control</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - prevention & control</topic><topic>COVID-19 Vaccines</topic><topic>Cross-Over Studies</topic><topic>England - epidemiology</topic><topic>Female</topic><topic>Heterogeneity</topic><topic>Households</topic><topic>Humans</topic><topic>Immunization</topic><topic>Male</topic><topic>Mitigations</topic><topic>Public health</topic><topic>Risk management</topic><topic>SARS-CoV-2</topic><topic>Self Report</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Subgroups</topic><topic>Vaccination</topic><topic>Vaccine</topic><topic>Vaccine efficacy</topic><topic>Vaccines</topic><topic>Wales - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serisier, Aimee</creatorcontrib><creatorcontrib>Beale, Sarah</creatorcontrib><creatorcontrib>Boukari, Yamina</creatorcontrib><creatorcontrib>Hoskins, Susan</creatorcontrib><creatorcontrib>Nguyen, Vincent</creatorcontrib><creatorcontrib>Byrne, Thomas</creatorcontrib><creatorcontrib>Fong, Wing Lam Erica</creatorcontrib><creatorcontrib>Fragaszy, Ellen</creatorcontrib><creatorcontrib>Geismar, Cyril</creatorcontrib><creatorcontrib>Kovar, Jana</creatorcontrib><creatorcontrib>Yavlinsky, Alexei</creatorcontrib><creatorcontrib>Hayward, Andrew</creatorcontrib><creatorcontrib>Aldridge, Robert W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serisier, Aimee</au><au>Beale, Sarah</au><au>Boukari, Yamina</au><au>Hoskins, Susan</au><au>Nguyen, Vincent</au><au>Byrne, Thomas</au><au>Fong, Wing Lam Erica</au><au>Fragaszy, Ellen</au><au>Geismar, Cyril</au><au>Kovar, Jana</au><au>Yavlinsky, Alexei</au><au>Hayward, Andrew</au><au>Aldridge, Robert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2023-01-09</date><risdate>2023</risdate><volume>41</volume><issue>2</issue><spage>511</spage><epage>518</epage><pages>511-518</pages><issn>0264-410X</issn><issn>1873-2518</issn><eissn>1873-2518</eissn><abstract>Studies of COVID-19 vaccine effectiveness show increases in COVID-19 cases within 14 days of a first dose, potentially reflecting post-vaccination behaviour changes associated with SARS-CoV-2 transmission before vaccine protection. However, direct evidence for a relationship between vaccination and behaviour is lacking. We aimed to examine the association between vaccination status and self-reported non-household contacts and non-essential activities during a national lockdown in England and Wales.
Participants (n = 1154) who had received the first dose of a COVID-19 vaccine reported non-household contacts and non-essential activities from February to March 2021 in monthly surveys during a national lockdown in England and Wales. We used a case-crossover study design and conditional logistic regression to examine the association between vaccination status (pre-vaccination vs 14 days post-vaccination) and self-reported contacts and activities within individuals. Stratified subgroup analyses examined potential effect heterogeneity by sociodemographic characteristics such as sex, household income or age group.
457/1154 (39.60 %) participants reported non-household contacts post-vaccination compared with 371/1154 (32.15 %) participants pre-vaccination. 100/1154 (8.67 %) participants reported use of non-essential shops or services post-vaccination compared with 74/1154 (6.41 %) participants pre-vaccination. Post-vaccination status was associated with increased odds of reporting non-household contacts (OR 1.65, 95 % CI 1.31–2.06, p < 0.001) and use of non-essential shops or services (OR 1.50, 95 % CI 1.03–2.17, p = 0.032). This effect varied between men and women and different age groups.
Participants had higher odds of reporting non-household contacts and use of non-essential shops or services within 14 days of their first COVID-19 vaccine compared to pre-vaccination. Public health emphasis on maintaining protective behaviours during this post-vaccination time period when individuals have yet to develop full protection from vaccination could reduce risk of SARS-CoV-2 infection.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>36496282</pmid><doi>10.1016/j.vaccine.2022.11.073</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0418-309X</orcidid><orcidid>https://orcid.org/0000-0002-4038-7460</orcidid><orcidid>https://orcid.org/0000-0001-6193-9159</orcidid><orcidid>https://orcid.org/0000-0003-0542-0816</orcidid><orcidid>https://orcid.org/0000-0002-9776-6242</orcidid><orcidid>https://orcid.org/0000-0002-3549-6232</orcidid><orcidid>https://orcid.org/0000-0002-8486-5890</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0264-410X |
ispartof | Vaccine, 2023-01, Vol.41 (2), p.511-518 |
issn | 0264-410X 1873-2518 1873-2518 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9721283 |
source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
subjects | Behaviour Case studies Communicable Disease Control Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - prevention & control COVID-19 Vaccines Cross-Over Studies England - epidemiology Female Heterogeneity Households Humans Immunization Male Mitigations Public health Risk management SARS-CoV-2 Self Report Severe acute respiratory syndrome coronavirus 2 Subgroups Vaccination Vaccine Vaccine efficacy Vaccines Wales - epidemiology |
title | A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T11%3A54%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20case-crossover%20study%20of%20the%20effect%20of%20vaccination%20on%20SARS-CoV-2%20transmission%20relevant%20behaviours%20during%20a%20period%20of%20national%20lockdown%20in%20England%20and%20Wales&rft.jtitle=Vaccine&rft.au=Serisier,%20Aimee&rft.date=2023-01-09&rft.volume=41&rft.issue=2&rft.spage=511&rft.epage=518&rft.pages=511-518&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2022.11.073&rft_dat=%3Cproquest_pubme%3E2759702548%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2759702548&rft_id=info:pmid/36496282&rft_els_id=S0264410X22014979&rfr_iscdi=true |