Computed Tomographic Thickness of Retrobulbar Optic Nerve Is Decreased in Glaucoma Patients and Is Negatively Correlated With Disease Severity
Purpose The purpose of the study was to quantitatively measure the width of the retrobulbar optic nerve-sheath complex by computed tomography (CT) in glaucoma and evaluate its relationship with optic nerve changes and visual field loss parameters. Methods Sixty-six eyes of 33 patients with bilateral...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-11, Vol.14 (11), p.e31066-e31066 |
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| description | Purpose The purpose of the study was to quantitatively measure the width of the retrobulbar optic nerve-sheath complex by computed tomography (CT) in glaucoma and evaluate its relationship with optic nerve changes and visual field loss parameters. Methods Sixty-six eyes of 33 patients with bilateral asymmetric glaucomatous optic nerve damage and 20 eyes of 20 age- and sex-matched control subjects without glaucoma were included. Axial retrobulbar optic nerve-sheath complex was measured by CT in the eyes with advanced glaucomatous damage (group 1); in the fellow eyes of the same patients with moderate glaucomatous damage (group 2); and in control subjects (group 3). Measurements were obtained at three different points: just behind the globe, near the optic canal, and in the middle. Results Mean age and sex distribution between groups were comparable (p>0.05). The mean diameters of the retrobulbar optic nerve at three measurement points in group 1 (4.00±0.42mm, 3.49±0.44mm, 3.18±0.45mm) were significantly (for each, |
| doi_str_mv | 10.7759/cureus.31066 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9719404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2759773775</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-ea31968895e361906861dd2c8f9ac68c93ed4e965ce831c5c518573879227b3d3</originalsourceid><addsrcrecordid>eNpdkU1vEzEQhlcIRKu2N87IEhcOpLXX668LEkqhVKpaBEEcLcc7SVx211t_RMqf4DfjbdqqcBmPPM-8M6O3qt4QfCoEU2c2B8jxlBLM-YvqsCZcziSRzctn-UF1EuMtxphgUWOBX1cHlDeCEVUfVn_mvh9zghYtfO_XwYwbZ9GihN8DxIj8Cn2HFPwyd0sT0M2YSvkawhbQZUTnYAOYWLrdgC46k63vDfpmkoMhRWSGdqKuYV1-ttDt0NyHAJ2Z5v1yaYPOXZz60Q_YQnBpd1y9WpkuwsnDe1T9_PJ5Mf86u7q5uJx_uppZ2tRpBoYSxaVUDCgnCnPJSdvWVq6UsVxaRaFtQHFmQVJimWVEMkGlUHUtlrSlR9XHve6Ylz20tqwbTKfH4HoTdtobp_-tDG6j136rlSCqwU0ReP8gEPxdhph076KFrjMD-Bx1LRilhDVYFvTdf-itz2Eo502UEoIWKwv1YU_Z4GMMsHpahmA9ea33Xut7rwv-9vkBT_Cjs_QvtbenyA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2759773775</pqid></control><display><type>article</type><title>Computed Tomographic Thickness of Retrobulbar Optic Nerve Is Decreased in Glaucoma Patients and Is Negatively Correlated With Disease Severity</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Evereklioglu, Cem ; Gulmez Sevim, Duygu ; Horozoglu, Fatih ; Polat, Osman A ; Sener, Hidayet ; Coskun, Abdulhakim ; Ozturk, Ahmet</creator><creatorcontrib>Evereklioglu, Cem ; Gulmez Sevim, Duygu ; Horozoglu, Fatih ; Polat, Osman A ; Sener, Hidayet ; Coskun, Abdulhakim ; Ozturk, Ahmet</creatorcontrib><description>Purpose The purpose of the study was to quantitatively measure the width of the retrobulbar optic nerve-sheath complex by computed tomography (CT) in glaucoma and evaluate its relationship with optic nerve changes and visual field loss parameters. Methods Sixty-six eyes of 33 patients with bilateral asymmetric glaucomatous optic nerve damage and 20 eyes of 20 age- and sex-matched control subjects without glaucoma were included. Axial retrobulbar optic nerve-sheath complex was measured by CT in the eyes with advanced glaucomatous damage (group 1); in the fellow eyes of the same patients with moderate glaucomatous damage (group 2); and in control subjects (group 3). Measurements were obtained at three different points: just behind the globe, near the optic canal, and in the middle. Results Mean age and sex distribution between groups were comparable (p>0.05). The mean diameters of the retrobulbar optic nerve at three measurement points in group 1 (4.00±0.42mm, 3.49±0.44mm, 3.18±0.45mm) were significantly (for each,
<0.05) lower when compared with the corresponding points of group 2 eyes (4.24±0.41mm, 3.77±0.47nn, 3.47mm±0.44mm) and normal controls (4.58±0.44mm, 4.15±0.45mm, 3.92±0.48mm). Optic disc changes and visual field parameters were negatively correlated with retrobulbar optic nerve diameter (for each,
< 0.05). Conclusion Radiological alterations of the retrobulbar optic nerve in glaucomatous eyes revealed a decreased optic nerve diameter which correlated with disease severity. Optic nerve dimensions below the lower limit for normal individuals may be considered pathologically reduced and, therefore, CT measurements of the retrobulbar nerve may be additive to the traditional triad of raised intraocular pressure, field defects, and optic disc changes in some cases with opaque optic media preventing the fundus examination or with optic nerve anomalies.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.31066</identifier><identifier>PMID: 36475192</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Disease ; Glaucoma ; Ophthalmology ; Optic nerve ; Orbits ; Other ; Radiology ; Tomography ; Visual acuity</subject><ispartof>Curēus (Palo Alto, CA), 2022-11, Vol.14 (11), p.e31066-e31066</ispartof><rights>Copyright © 2022, Evereklioglu et al.</rights><rights>Copyright © 2022, Evereklioglu et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Evereklioglu et al. 2022 Evereklioglu et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-ea31968895e361906861dd2c8f9ac68c93ed4e965ce831c5c518573879227b3d3</citedby><cites>FETCH-LOGICAL-c342t-ea31968895e361906861dd2c8f9ac68c93ed4e965ce831c5c518573879227b3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719404/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719404/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27904,27905,53771,53773</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36475192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evereklioglu, Cem</creatorcontrib><creatorcontrib>Gulmez Sevim, Duygu</creatorcontrib><creatorcontrib>Horozoglu, Fatih</creatorcontrib><creatorcontrib>Polat, Osman A</creatorcontrib><creatorcontrib>Sener, Hidayet</creatorcontrib><creatorcontrib>Coskun, Abdulhakim</creatorcontrib><creatorcontrib>Ozturk, Ahmet</creatorcontrib><title>Computed Tomographic Thickness of Retrobulbar Optic Nerve Is Decreased in Glaucoma Patients and Is Negatively Correlated With Disease Severity</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Purpose The purpose of the study was to quantitatively measure the width of the retrobulbar optic nerve-sheath complex by computed tomography (CT) in glaucoma and evaluate its relationship with optic nerve changes and visual field loss parameters. Methods Sixty-six eyes of 33 patients with bilateral asymmetric glaucomatous optic nerve damage and 20 eyes of 20 age- and sex-matched control subjects without glaucoma were included. Axial retrobulbar optic nerve-sheath complex was measured by CT in the eyes with advanced glaucomatous damage (group 1); in the fellow eyes of the same patients with moderate glaucomatous damage (group 2); and in control subjects (group 3). Measurements were obtained at three different points: just behind the globe, near the optic canal, and in the middle. Results Mean age and sex distribution between groups were comparable (p>0.05). The mean diameters of the retrobulbar optic nerve at three measurement points in group 1 (4.00±0.42mm, 3.49±0.44mm, 3.18±0.45mm) were significantly (for each,
<0.05) lower when compared with the corresponding points of group 2 eyes (4.24±0.41mm, 3.77±0.47nn, 3.47mm±0.44mm) and normal controls (4.58±0.44mm, 4.15±0.45mm, 3.92±0.48mm). Optic disc changes and visual field parameters were negatively correlated with retrobulbar optic nerve diameter (for each,
< 0.05). Conclusion Radiological alterations of the retrobulbar optic nerve in glaucomatous eyes revealed a decreased optic nerve diameter which correlated with disease severity. Optic nerve dimensions below the lower limit for normal individuals may be considered pathologically reduced and, therefore, CT measurements of the retrobulbar nerve may be additive to the traditional triad of raised intraocular pressure, field defects, and optic disc changes in some cases with opaque optic media preventing the fundus examination or with optic nerve anomalies.</description><subject>Disease</subject><subject>Glaucoma</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Orbits</subject><subject>Other</subject><subject>Radiology</subject><subject>Tomography</subject><subject>Visual acuity</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1vEzEQhlcIRKu2N87IEhcOpLXX668LEkqhVKpaBEEcLcc7SVx211t_RMqf4DfjbdqqcBmPPM-8M6O3qt4QfCoEU2c2B8jxlBLM-YvqsCZcziSRzctn-UF1EuMtxphgUWOBX1cHlDeCEVUfVn_mvh9zghYtfO_XwYwbZ9GihN8DxIj8Cn2HFPwyd0sT0M2YSvkawhbQZUTnYAOYWLrdgC46k63vDfpmkoMhRWSGdqKuYV1-ttDt0NyHAJ2Z5v1yaYPOXZz60Q_YQnBpd1y9WpkuwsnDe1T9_PJ5Mf86u7q5uJx_uppZ2tRpBoYSxaVUDCgnCnPJSdvWVq6UsVxaRaFtQHFmQVJimWVEMkGlUHUtlrSlR9XHve6Ylz20tqwbTKfH4HoTdtobp_-tDG6j136rlSCqwU0ReP8gEPxdhph076KFrjMD-Bx1LRilhDVYFvTdf-itz2Eo502UEoIWKwv1YU_Z4GMMsHpahmA9ea33Xut7rwv-9vkBT_Cjs_QvtbenyA</recordid><startdate>20221103</startdate><enddate>20221103</enddate><creator>Evereklioglu, Cem</creator><creator>Gulmez Sevim, Duygu</creator><creator>Horozoglu, Fatih</creator><creator>Polat, Osman A</creator><creator>Sener, Hidayet</creator><creator>Coskun, Abdulhakim</creator><creator>Ozturk, Ahmet</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221103</creationdate><title>Computed Tomographic Thickness of Retrobulbar Optic Nerve Is Decreased in Glaucoma Patients and Is Negatively Correlated With Disease Severity</title><author>Evereklioglu, Cem ; Gulmez Sevim, Duygu ; Horozoglu, Fatih ; Polat, Osman A ; Sener, Hidayet ; Coskun, Abdulhakim ; Ozturk, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-ea31968895e361906861dd2c8f9ac68c93ed4e965ce831c5c518573879227b3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Disease</topic><topic>Glaucoma</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Orbits</topic><topic>Other</topic><topic>Radiology</topic><topic>Tomography</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evereklioglu, Cem</creatorcontrib><creatorcontrib>Gulmez Sevim, Duygu</creatorcontrib><creatorcontrib>Horozoglu, Fatih</creatorcontrib><creatorcontrib>Polat, Osman A</creatorcontrib><creatorcontrib>Sener, Hidayet</creatorcontrib><creatorcontrib>Coskun, Abdulhakim</creatorcontrib><creatorcontrib>Ozturk, Ahmet</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evereklioglu, Cem</au><au>Gulmez Sevim, Duygu</au><au>Horozoglu, Fatih</au><au>Polat, Osman A</au><au>Sener, Hidayet</au><au>Coskun, Abdulhakim</au><au>Ozturk, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computed Tomographic Thickness of Retrobulbar Optic Nerve Is Decreased in Glaucoma Patients and Is Negatively Correlated With Disease Severity</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2022-11-03</date><risdate>2022</risdate><volume>14</volume><issue>11</issue><spage>e31066</spage><epage>e31066</epage><pages>e31066-e31066</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Purpose The purpose of the study was to quantitatively measure the width of the retrobulbar optic nerve-sheath complex by computed tomography (CT) in glaucoma and evaluate its relationship with optic nerve changes and visual field loss parameters. Methods Sixty-six eyes of 33 patients with bilateral asymmetric glaucomatous optic nerve damage and 20 eyes of 20 age- and sex-matched control subjects without glaucoma were included. Axial retrobulbar optic nerve-sheath complex was measured by CT in the eyes with advanced glaucomatous damage (group 1); in the fellow eyes of the same patients with moderate glaucomatous damage (group 2); and in control subjects (group 3). Measurements were obtained at three different points: just behind the globe, near the optic canal, and in the middle. Results Mean age and sex distribution between groups were comparable (p>0.05). The mean diameters of the retrobulbar optic nerve at three measurement points in group 1 (4.00±0.42mm, 3.49±0.44mm, 3.18±0.45mm) were significantly (for each,
<0.05) lower when compared with the corresponding points of group 2 eyes (4.24±0.41mm, 3.77±0.47nn, 3.47mm±0.44mm) and normal controls (4.58±0.44mm, 4.15±0.45mm, 3.92±0.48mm). Optic disc changes and visual field parameters were negatively correlated with retrobulbar optic nerve diameter (for each,
< 0.05). Conclusion Radiological alterations of the retrobulbar optic nerve in glaucomatous eyes revealed a decreased optic nerve diameter which correlated with disease severity. Optic nerve dimensions below the lower limit for normal individuals may be considered pathologically reduced and, therefore, CT measurements of the retrobulbar nerve may be additive to the traditional triad of raised intraocular pressure, field defects, and optic disc changes in some cases with opaque optic media preventing the fundus examination or with optic nerve anomalies.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>36475192</pmid><doi>10.7759/cureus.31066</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Disease Glaucoma Ophthalmology Optic nerve Orbits Other Radiology Tomography Visual acuity |
| title | Computed Tomographic Thickness of Retrobulbar Optic Nerve Is Decreased in Glaucoma Patients and Is Negatively Correlated With Disease Severity |
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