Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H + -driven lysosomal pyridoxine exporter

Disrupted in renal carcinoma 2 (DIRC2) has gained interest because of its association with the development of renal cancer and cosegregation with a chromosomal translocation. It is a member of the SLC49 family (SLC49A4) and is considered to be an electrogenic lysosomal metabolite transporter; howeve...

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Veröffentlicht in:	Life science alliance 2023-02, Vol.6 (2), p.e202201629
Hauptverfasser:	Akino, Shogo, Yasujima, Tomoya, Yamashiro, Takahiro, Yuasa, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells Carcinoma, Renal Cell - genetics Humans Kidney Neoplasms - genetics Lysosomes Membrane Transport Proteins - genetics Pyridoxine Thiamine
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