Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent
Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in cl...
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| Veröffentlicht in: | Integrative Cancer Therapies 2022-01, Vol.21, p.15347354221132848 |
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| creator | Chanthira Kumar, Hemahwathy Lim, Xin Yi Mohkiar, Farah Huda Suhaimi, Shazlan Noor Mohammad Shafie, Nurmaziah Chin Tan, Terence Yew |
| description | Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment. |
| doi_str_mv | 10.1177/15347354221132848 |
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A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment.</description><identifier>ISSN: 1534-7354</identifier><identifier>ISSN: 1552-695X</identifier><identifier>EISSN: 1552-695X</identifier><identifier>DOI: 10.1177/15347354221132848</identifier><identifier>PMID: 36448674</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Antineoplastic Agents - adverse effects ; Antitumor activity ; Antitumor agents ; Apoptosis ; Cancer ; Herbal medicine ; Humans ; Immunomodulation ; Immunotherapy ; Inflammation ; Medicinal plants ; Morbidity ; Morinda ; Morinda citrifolia ; Review ; Safety</subject><ispartof>Integrative Cancer Therapies, 2022-01, Vol.21, p.15347354221132848</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022 2022 SAGE Publications Inc unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-92e8b76585d1d3b20dbafdcf73121b2ee0834fe5aaed1baa27035520c1e6f2383</citedby><cites>FETCH-LOGICAL-c466t-92e8b76585d1d3b20dbafdcf73121b2ee0834fe5aaed1baa27035520c1e6f2383</cites><orcidid>0000-0001-7178-7435 ; 0000-0003-2913-5673 ; 0000-0002-2615-3166 ; 0000-0002-3629-3920 ; 0000-0001-7553-3600</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716600/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716600/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,723,776,780,788,860,881,21946,27832,27901,27903,27904,44924,45312,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36448674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chanthira Kumar, Hemahwathy</creatorcontrib><creatorcontrib>Lim, Xin Yi</creatorcontrib><creatorcontrib>Mohkiar, Farah Huda</creatorcontrib><creatorcontrib>Suhaimi, Shazlan Noor</creatorcontrib><creatorcontrib>Mohammad Shafie, Nurmaziah</creatorcontrib><creatorcontrib>Chin Tan, Terence Yew</creatorcontrib><title>Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent</title><title>Integrative Cancer Therapies</title><addtitle>Integr Cancer Ther</addtitle><description>Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment.</description><subject>Antineoplastic Agents - adverse effects</subject><subject>Antitumor activity</subject><subject>Antitumor agents</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Immunomodulation</subject><subject>Immunotherapy</subject><subject>Inflammation</subject><subject>Medicinal plants</subject><subject>Morbidity</subject><subject>Morinda</subject><subject>Morinda citrifolia</subject><subject>Review</subject><subject>Safety</subject><issn>1534-7354</issn><issn>1552-695X</issn><issn>1552-695X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kV1LXDEQhoNU1Nr-AG8k0Bt7cbb5TvamsIgfhbUKttC7MCcn2UbOnmhyVth_b5a11rb0aobJM-_k5UXoiJIJpVp_opILzaVgjFLOjDA76IBKyRo1lT_ebHoumg2wj96WckcIo0TJPbTPlRBGaXGAbs9CiA7cGsPQ4VsIflzjFPBVynHoALs45hhSHwHPJ_jkaxriRwwFA75Jox_GCD2e1eJgcD7j2aLO3qHdAH3x75_rIfp-fvbt9LKZX198OZ3NGyeUGpsp86bVShrZ0Y63jHQthM4FzSmjLfOeGC6ClwC-oy0A04RXc8RRrwLjhh-iz1vd-1W79J2rpzP09j7HJeS1TRDtny9D_GkX6dFONVWKkCpw8iyQ08PKl9EuY3G-72HwaVUs04JLYohiFf3wF3qXVnmo9ipVLRgmma4U3VIup1KyDy-focRuIrP_RFZ3jl-7eNn4lVEFJlugwML_Pvt_xSd1PZ1s</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Chanthira Kumar, Hemahwathy</creator><creator>Lim, Xin Yi</creator><creator>Mohkiar, Farah Huda</creator><creator>Suhaimi, Shazlan Noor</creator><creator>Mohammad Shafie, Nurmaziah</creator><creator>Chin Tan, Terence Yew</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7178-7435</orcidid><orcidid>https://orcid.org/0000-0003-2913-5673</orcidid><orcidid>https://orcid.org/0000-0002-2615-3166</orcidid><orcidid>https://orcid.org/0000-0002-3629-3920</orcidid><orcidid>https://orcid.org/0000-0001-7553-3600</orcidid></search><sort><creationdate>20220101</creationdate><title>Efficacy and Safety of Morinda citrifolia L. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antineoplastic Agents - adverse effects Antitumor activity Antitumor agents Apoptosis Cancer Herbal medicine Humans Immunomodulation Immunotherapy Inflammation Medicinal plants Morbidity Morinda Morinda citrifolia Review Safety |
| title | Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent |
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