Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase

Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the first and rate-limiting step of the Kyn pathway. To identify new s...

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Veröffentlicht in:	International journal of tryptophan research 2022-01, Vol.15, p.11786469221138456-11786469221138456
Hauptverfasser:	Yoshioka, Saeko, Ikeda, Tomonori, Fukuchi, Sogo, Kawai, Yurika, Ohta, Katsumi, Murakami, Hisashi, Ogo, Naohisa, Muraoka, Daisuke, Takikawa, Osamu, Asai, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzymes Original Research
Online-Zugang:	Volltext
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