NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy

Oxaliplatin is an antineoplastic agent frequently used in the treatment of gastrointestinal tumors. However, it causes dose-limiting sensorimotor neuropathy, referred to as oxaliplatin-induced peripheral neuropathy (OIPN), for which there is no effective treatment. Here, we report that the elevation...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer immunology research 2022-12, Vol.10 (12), p.1542-1558
Hauptverfasser:	Lin, Tongtong, Hu, Liang, Hu, Fan, Li, Kun, Wang, Chao-Yu, Zong, Li-Juan, Zhao, Ya-Qian, Zhang, Xiaotao, Li, Yan, Yang, Yang, Wang, Yu, Jiang, Chun-Yi, Wu, Xuefeng, Liu, Wen-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Extracellular Traps - metabolism Hyperalgesia - chemically induced Hyperalgesia - metabolism Inflammasomes - metabolism Interleukin-18 - metabolism Mice NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oxaliplatin - adverse effects Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!