Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma

Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single ce...

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Veröffentlicht in:	Cancer discovery 2022-12, Vol.12 (12), p.2820-2837
Hauptverfasser:	Wu, Lingxiang, Wu, Wei, Zhang, Junxia, Zhao, Zheng, Li, Liangyu, Zhu, Mengyan, Wu, Min, Wu, Fan, Zhou, Fengqi, Du, Yuxin, Chai, Rui-Chao, Zhang, Wei, Qiu, Xiaoguang, Liu, Quanzhong, Wang, Ziyu, Li, Jie, Li, Kening, Chen, Apeng, Jiang, Yinan, Xiao, Xiangwei, Zou, Han, Srivastava, Rashmi, Zhang, Tingting, Cai, Yun, Liang, Yuan, Huang, Bin, Zhang, Ruohan, Lin, Fan, Hu, Lang, Wang, Xiuxing, Qian, Xu, Lv, Sali, Hu, Baoli, Zheng, Siyuan, Hu, Zhibin, Shen, Hongbing, You, Yongping, Verhaak, Roel G W, Jiang, Tao, Wang, Qianghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - genetics Brain Neoplasms - pathology Glioblastoma - genetics Glioblastoma - pathology Humans Hypoxia - genetics Isocitrate Dehydrogenase - genetics Prognosis
Online-Zugang:	Volltext
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