Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma
It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) marke...
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| Veröffentlicht in: | Journal of veterinary science (Suwŏn-si, Korea) Korea), 2022-11, Vol.23 (6), p.106-112 |
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| container_title | Journal of veterinary science (Suwŏn-si, Korea) |
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| creator | Tangchang, Warisraporn Kim, YunHyeok Oh, Ye-In Lee, Byung-Woo Kim, Hyunwook Yoon, Byungil |
| description | It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas. |
| doi_str_mv | 10.4142/jvs.22124 |
| format | Article |
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We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas.</description><identifier>ISSN: 1229-845X</identifier><identifier>EISSN: 1976-555X</identifier><identifier>DOI: 10.4142/jvs.22124</identifier><identifier>PMID: 36448435</identifier><language>eng</language><publisher>Korea (South): 대한수의학회</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - veterinary ; Animals ; Biomarkers ; Dog Diseases - diagnosis ; Dogs ; Heterografts ; Mice ; Mice, Nude ; Neoplastic Stem Cells ; Rapid Communication ; Transplantation, Heterologous - veterinary</subject><ispartof>Journal of veterinary science (Suwŏn-si, Korea), 2022-11, Vol.23 (6), p.106-112</ispartof><rights>2022 The Korean Society of Veterinary Science.</rights><rights>2022 The Korean Society of Veterinary Science 2022 The Korean Society of Veterinary Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-80ccd7f819304da128fb301fa8bbc0cbbdf5e485bb73cd182eead72bf7ca77e3</citedby><cites>FETCH-LOGICAL-c405t-80ccd7f819304da128fb301fa8bbc0cbbdf5e485bb73cd182eead72bf7ca77e3</cites><orcidid>0000-0001-8082-2458 ; 0000-0001-8944-2638 ; 0000-0003-4809-9903 ; 0000-0002-0044-6462 ; 0000-0002-9043-7307 ; 0000-0002-0916-3872</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715391/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715391/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36448435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tangchang, Warisraporn</creatorcontrib><creatorcontrib>Kim, YunHyeok</creatorcontrib><creatorcontrib>Oh, Ye-In</creatorcontrib><creatorcontrib>Lee, Byung-Woo</creatorcontrib><creatorcontrib>Kim, Hyunwook</creatorcontrib><creatorcontrib>Yoon, Byungil</creatorcontrib><title>Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma</title><title>Journal of veterinary science (Suwŏn-si, Korea)</title><addtitle>J Vet Sci</addtitle><description>It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - veterinary</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Dog Diseases - diagnosis</subject><subject>Dogs</subject><subject>Heterografts</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplastic Stem Cells</subject><subject>Rapid Communication</subject><subject>Transplantation, Heterologous - veterinary</subject><issn>1229-845X</issn><issn>1976-555X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkTtvFDEUhS0EIiFQ8AeQGyQoJvi59jRI0RIeUkSaFOksPxeHGXuxZyIo88_j2V1WUPlxPp97fQ8ArzE6Z5iRD3f39ZwQTNgTcIp7seo457dP256QvpOM356AF7XeIUQJX_XPwQldMSYZ5afgYV3iFK0eoIt6k3JtB6iTg1Yn6wuskx-h9cMAR11--lJhTDD5vB30Dl2kCkPJ4_IiJg-3JTb0z87kt095U3SYvIPbeRhz2imuXVtdbEx51C_Bs6CH6l8d1jNw8_nyZv21u7r-8m19cdVZhvjUSWStE0HiniLmNCYyGIpw0NIYi6wxLnDPJDdGUOuwJN5rJ4gJwmohPD0DH_e229mM3lmfpqIHdehWZR3V_0qKP9Qm36teYE573AzeHQxK_jX7Oqkx1uX7uo1jroqINlAkkVjQ93vUllxr8eFYBiO1JKZaYmqXWGPf_NvXkfwbUQPe7oE0N8m3mI7M9-tPlxjTfkUopY-XnKPS</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Tangchang, Warisraporn</creator><creator>Kim, YunHyeok</creator><creator>Oh, Ye-In</creator><creator>Lee, Byung-Woo</creator><creator>Kim, Hyunwook</creator><creator>Yoon, Byungil</creator><general>대한수의학회</general><general>The Korean Society of Veterinary Science</general><scope>DBRKI</scope><scope>TDB</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8082-2458</orcidid><orcidid>https://orcid.org/0000-0001-8944-2638</orcidid><orcidid>https://orcid.org/0000-0003-4809-9903</orcidid><orcidid>https://orcid.org/0000-0002-0044-6462</orcidid><orcidid>https://orcid.org/0000-0002-9043-7307</orcidid><orcidid>https://orcid.org/0000-0002-0916-3872</orcidid></search><sort><creationdate>20221101</creationdate><title>Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma</title><author>Tangchang, Warisraporn ; Kim, YunHyeok ; Oh, Ye-In ; Lee, Byung-Woo ; Kim, Hyunwook ; Yoon, Byungil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-80ccd7f819304da128fb301fa8bbc0cbbdf5e485bb73cd182eead72bf7ca77e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - veterinary</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Dog Diseases - diagnosis</topic><topic>Dogs</topic><topic>Heterografts</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplastic Stem Cells</topic><topic>Rapid Communication</topic><topic>Transplantation, Heterologous - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tangchang, Warisraporn</creatorcontrib><creatorcontrib>Kim, YunHyeok</creatorcontrib><creatorcontrib>Oh, Ye-In</creatorcontrib><creatorcontrib>Lee, Byung-Woo</creatorcontrib><creatorcontrib>Kim, Hyunwook</creatorcontrib><creatorcontrib>Yoon, Byungil</creatorcontrib><collection>DBPIA - 디비피아</collection><collection>DBPIA</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary science (Suwŏn-si, Korea)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tangchang, Warisraporn</au><au>Kim, YunHyeok</au><au>Oh, Ye-In</au><au>Lee, Byung-Woo</au><au>Kim, Hyunwook</au><au>Yoon, Byungil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma</atitle><jtitle>Journal of veterinary science (Suwŏn-si, Korea)</jtitle><addtitle>J Vet Sci</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>23</volume><issue>6</issue><spage>106</spage><epage>112</epage><pages>106-112</pages><issn>1229-845X</issn><eissn>1976-555X</eissn><abstract>It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). 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| source | KoreaMed Synapse; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; KoreaMed Open Access; PubMed Central |
| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - veterinary Animals Biomarkers Dog Diseases - diagnosis Dogs Heterografts Mice Mice, Nude Neoplastic Stem Cells Rapid Communication Transplantation, Heterologous - veterinary |
| title | Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma |
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