Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis

Intron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development; however, the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. Here we show that IR is a physiological process that is spat...

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Veröffentlicht in:	Genome research 2022-10, Vol.32 (10), p.1808-1825
Hauptverfasser:	Petrić Howe, Marija, Crerar, Hamish, Neeves, Jacob, Harley, Jasmine, Tyzack, Giulia E, Klein, Pierre, Ramos, Andres, Patani, Rickie, Luisier, Raphaëlle
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytoplasm Cytoplasm - genetics Cytoplasm - metabolism Gene expression Humans Introns MicroRNAs - genetics MicroRNAs - metabolism miRNA Motor Neurons Neurogenesis Neurogenesis - genetics Physiology RNA-binding protein
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