Decreasing Wapl dosage partially corrects embryonic growth and brain transcriptome phenotypes in Nipbl +/- embryos

Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for causes a developmental disorder, Cornelia de Lange syndrome (CdLS), that is modeled by mice. Mutations in have not been shown to caus...

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Veröffentlicht in:	Science advances 2022-12, Vol.8 (48), p.eadd4136
Hauptverfasser:	Kean, Connor M, Tracy, Christopher J, Mitra, Apratim, Rahat, Beenish, Van Winkle, Matthew T, Gebert, Claudia M, Noeker, Jacob A, Calof, Anne L, Lander, Arthur D, Kassis, Judith A, Pfeifer, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedicine and Life Sciences Brain Cell Cycle Proteins - genetics Female Genetics Heterozygote Humans Life Sciences Mammals Mice Mutation Phenotype Pregnancy Proteins SciAdv r-articles Transcriptome
Online-Zugang:	Volltext
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