A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals
Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitability could be enhanced through the development of new marke...
Gespeichert in:
| Veröffentlicht in: | Journal of flow chemistry 2022-11, Vol.13 (2), p.77-90 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 90 |
|---|---|
| container_issue | 2 |
| container_start_page | 77 |
| container_title | Journal of flow chemistry |
| container_volume | 13 |
| creator | Kaisin, Geoffroy Bovy, Loïc Joyard, Yoann Maindron, Nicolas Tadino, Vincent Monbaliu, Jean-Christophe M. |
| description | Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitability could be enhanced through the development of new market opportunities for these biobased platform chemicals. The fine chemical industry, and more specifically the manufacturing of pharmaceuticals is one of the sectors bearing significant potential for these biobased building blocks to rapidly emerge and make a difference. There are, however, still many challenges to be dealt with before this market can thrive. Continuous flow technology and its integration for the upgrading of biobased platform molecules for the manufacturing of pharmaceuticals is foreseen as a game-changer. This perspective reflects on the main challenges relative to chemical, process, regulatory and supply chain-related burdens still to be addressed. The implementation of integrated continuous flow processes and their automation into modular units will help for tackling with these challenges.
Graphical abstract |
| doi_str_mv | 10.1007/s41981-022-00247-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9707424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2747006237</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-d6319bdcdb204bdb80846f5eef2a6f18e0f66a76da3b686210f8888a956704cc3</originalsourceid><addsrcrecordid>eNp9kctu1TAQhiMEolXpC7BAXrIJ2I6PnWyQqoqbVIkNSOysiTPJcZXYwZdT9QV4bnxySoENs5nRXH6P56uql4y-YZSqt1GwrmU15bymlAtVd0-qc05lU1KMP91iXnPRfT-rLmO8pcV2TDacPa_OGimk6pQ6r35ekRVDXNEke0DiHYGc_AIJBwLDAZwpgfEuWZd9jmSc_R1ZwOURTMrBuolkZ1Mp-EDSHklepwDDMe9H0lvfQzwq7HGxBuZIkr-DMJB1D2EBgzlt6RfVs7E4vHzwF9W3D--_Xn-qb758_Hx9dVMb0dFUD7JhXT-YoedU9EPf0lbIcYc4cpAja5GOUoKSAzS9bCVndGyLQbeTigpjmovq3Ul3zf2Cg0GXAsx6DXaBcK89WP1vxdm9nvxBd4oqwUURaE4Cs8UJtQ-91Qe-DW5xnicNRveoOZetbgqalpap1w_PBv8jY0x6sdHgPIPDclXNlVC08GpUaeWnVhN8jAHHx-UY1Ufy-kReF_J6I6-7MvTq7289jvzm_GftuB6ZYdC3PgdXTv0_2V8zxL3C</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2747006237</pqid></control><display><type>article</type><title>A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals</title><source>SpringerNature Journals</source><creator>Kaisin, Geoffroy ; Bovy, Loïc ; Joyard, Yoann ; Maindron, Nicolas ; Tadino, Vincent ; Monbaliu, Jean-Christophe M.</creator><creatorcontrib>Kaisin, Geoffroy ; Bovy, Loïc ; Joyard, Yoann ; Maindron, Nicolas ; Tadino, Vincent ; Monbaliu, Jean-Christophe M.</creatorcontrib><description>Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitability could be enhanced through the development of new market opportunities for these biobased platform chemicals. The fine chemical industry, and more specifically the manufacturing of pharmaceuticals is one of the sectors bearing significant potential for these biobased building blocks to rapidly emerge and make a difference. There are, however, still many challenges to be dealt with before this market can thrive. Continuous flow technology and its integration for the upgrading of biobased platform molecules for the manufacturing of pharmaceuticals is foreseen as a game-changer. This perspective reflects on the main challenges relative to chemical, process, regulatory and supply chain-related burdens still to be addressed. The implementation of integrated continuous flow processes and their automation into modular units will help for tackling with these challenges.
Graphical abstract</description><identifier>ISSN: 2062-249X</identifier><identifier>ISSN: 2063-0212</identifier><identifier>EISSN: 2063-0212</identifier><identifier>DOI: 10.1007/s41981-022-00247-9</identifier><identifier>PMID: 36467977</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Active Pharmaceutical Ingredient ; Automation ; Biobased platforms ; Chemistry ; Chemistry (miscellaneous) ; Chemistry and Materials Science ; Chemistry/Food Science ; Chimie ; Flow chemistry ; Fluid Flow and Transfer Processes ; Green Chemistry ; Industrial Chemistry/Chemical Engineering ; Inorganic Chemistry ; Nanochemistry ; Organic Chemistry ; Perspectives ; Physical, chemical, mathematical & earth Sciences ; Physique, chimie, mathématiques & sciences de la terre</subject><ispartof>Journal of flow chemistry, 2022-11, Vol.13 (2), p.77-90</ispartof><rights>Akadémiai Kiadó 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>Akadémiai Kiadó 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-d6319bdcdb204bdb80846f5eef2a6f18e0f66a76da3b686210f8888a956704cc3</citedby><cites>FETCH-LOGICAL-c490t-d6319bdcdb204bdb80846f5eef2a6f18e0f66a76da3b686210f8888a956704cc3</cites><orcidid>0000-0002-3968-8506</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s41981-022-00247-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s41981-022-00247-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36467977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaisin, Geoffroy</creatorcontrib><creatorcontrib>Bovy, Loïc</creatorcontrib><creatorcontrib>Joyard, Yoann</creatorcontrib><creatorcontrib>Maindron, Nicolas</creatorcontrib><creatorcontrib>Tadino, Vincent</creatorcontrib><creatorcontrib>Monbaliu, Jean-Christophe M.</creatorcontrib><title>A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals</title><title>Journal of flow chemistry</title><addtitle>J Flow Chem</addtitle><addtitle>J Flow Chem</addtitle><description>Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitability could be enhanced through the development of new market opportunities for these biobased platform chemicals. The fine chemical industry, and more specifically the manufacturing of pharmaceuticals is one of the sectors bearing significant potential for these biobased building blocks to rapidly emerge and make a difference. There are, however, still many challenges to be dealt with before this market can thrive. Continuous flow technology and its integration for the upgrading of biobased platform molecules for the manufacturing of pharmaceuticals is foreseen as a game-changer. This perspective reflects on the main challenges relative to chemical, process, regulatory and supply chain-related burdens still to be addressed. The implementation of integrated continuous flow processes and their automation into modular units will help for tackling with these challenges.
Graphical abstract</description><subject>Active Pharmaceutical Ingredient</subject><subject>Automation</subject><subject>Biobased platforms</subject><subject>Chemistry</subject><subject>Chemistry (miscellaneous)</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chimie</subject><subject>Flow chemistry</subject><subject>Fluid Flow and Transfer Processes</subject><subject>Green Chemistry</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Inorganic Chemistry</subject><subject>Nanochemistry</subject><subject>Organic Chemistry</subject><subject>Perspectives</subject><subject>Physical, chemical, mathematical & earth Sciences</subject><subject>Physique, chimie, mathématiques & sciences de la terre</subject><issn>2062-249X</issn><issn>2063-0212</issn><issn>2063-0212</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1TAQhiMEolXpC7BAXrIJ2I6PnWyQqoqbVIkNSOysiTPJcZXYwZdT9QV4bnxySoENs5nRXH6P56uql4y-YZSqt1GwrmU15bymlAtVd0-qc05lU1KMP91iXnPRfT-rLmO8pcV2TDacPa_OGimk6pQ6r35ekRVDXNEke0DiHYGc_AIJBwLDAZwpgfEuWZd9jmSc_R1ZwOURTMrBuolkZ1Mp-EDSHklepwDDMe9H0lvfQzwq7HGxBuZIkr-DMJB1D2EBgzlt6RfVs7E4vHzwF9W3D--_Xn-qb758_Hx9dVMb0dFUD7JhXT-YoedU9EPf0lbIcYc4cpAja5GOUoKSAzS9bCVndGyLQbeTigpjmovq3Ul3zf2Cg0GXAsx6DXaBcK89WP1vxdm9nvxBd4oqwUURaE4Cs8UJtQ-91Qe-DW5xnicNRveoOZetbgqalpap1w_PBv8jY0x6sdHgPIPDclXNlVC08GpUaeWnVhN8jAHHx-UY1Ufy-kReF_J6I6-7MvTq7289jvzm_GftuB6ZYdC3PgdXTv0_2V8zxL3C</recordid><startdate>20221129</startdate><enddate>20221129</enddate><creator>Kaisin, Geoffroy</creator><creator>Bovy, Loïc</creator><creator>Joyard, Yoann</creator><creator>Maindron, Nicolas</creator><creator>Tadino, Vincent</creator><creator>Monbaliu, Jean-Christophe M.</creator><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3968-8506</orcidid></search><sort><creationdate>20221129</creationdate><title>A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals</title><author>Kaisin, Geoffroy ; Bovy, Loïc ; Joyard, Yoann ; Maindron, Nicolas ; Tadino, Vincent ; Monbaliu, Jean-Christophe M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-d6319bdcdb204bdb80846f5eef2a6f18e0f66a76da3b686210f8888a956704cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Active Pharmaceutical Ingredient</topic><topic>Automation</topic><topic>Biobased platforms</topic><topic>Chemistry</topic><topic>Chemistry (miscellaneous)</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Chimie</topic><topic>Flow chemistry</topic><topic>Fluid Flow and Transfer Processes</topic><topic>Green Chemistry</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Inorganic Chemistry</topic><topic>Nanochemistry</topic><topic>Organic Chemistry</topic><topic>Perspectives</topic><topic>Physical, chemical, mathematical & earth Sciences</topic><topic>Physique, chimie, mathématiques & sciences de la terre</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaisin, Geoffroy</creatorcontrib><creatorcontrib>Bovy, Loïc</creatorcontrib><creatorcontrib>Joyard, Yoann</creatorcontrib><creatorcontrib>Maindron, Nicolas</creatorcontrib><creatorcontrib>Tadino, Vincent</creatorcontrib><creatorcontrib>Monbaliu, Jean-Christophe M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of flow chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaisin, Geoffroy</au><au>Bovy, Loïc</au><au>Joyard, Yoann</au><au>Maindron, Nicolas</au><au>Tadino, Vincent</au><au>Monbaliu, Jean-Christophe M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals</atitle><jtitle>Journal of flow chemistry</jtitle><stitle>J Flow Chem</stitle><addtitle>J Flow Chem</addtitle><date>2022-11-29</date><risdate>2022</risdate><volume>13</volume><issue>2</issue><spage>77</spage><epage>90</epage><pages>77-90</pages><issn>2062-249X</issn><issn>2063-0212</issn><eissn>2063-0212</eissn><abstract>Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitability could be enhanced through the development of new market opportunities for these biobased platform chemicals. The fine chemical industry, and more specifically the manufacturing of pharmaceuticals is one of the sectors bearing significant potential for these biobased building blocks to rapidly emerge and make a difference. There are, however, still many challenges to be dealt with before this market can thrive. Continuous flow technology and its integration for the upgrading of biobased platform molecules for the manufacturing of pharmaceuticals is foreseen as a game-changer. This perspective reflects on the main challenges relative to chemical, process, regulatory and supply chain-related burdens still to be addressed. The implementation of integrated continuous flow processes and their automation into modular units will help for tackling with these challenges.
Graphical abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36467977</pmid><doi>10.1007/s41981-022-00247-9</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3968-8506</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2062-249X |
| ispartof | Journal of flow chemistry, 2022-11, Vol.13 (2), p.77-90 |
| issn | 2062-249X 2063-0212 2063-0212 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9707424 |
| source | SpringerNature Journals |
| subjects | Active Pharmaceutical Ingredient Automation Biobased platforms Chemistry Chemistry (miscellaneous) Chemistry and Materials Science Chemistry/Food Science Chimie Flow chemistry Fluid Flow and Transfer Processes Green Chemistry Industrial Chemistry/Chemical Engineering Inorganic Chemistry Nanochemistry Organic Chemistry Perspectives Physical, chemical, mathematical & earth Sciences Physique, chimie, mathématiques & sciences de la terre |
| title | A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T21%3A56%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20perspective%20on%20automated%20advanced%20continuous%20flow%20manufacturing%20units%20for%20the%20upgrading%20of%20biobased%20chemicals%20toward%20pharmaceuticals&rft.jtitle=Journal%20of%20flow%20chemistry&rft.au=Kaisin,%20Geoffroy&rft.date=2022-11-29&rft.volume=13&rft.issue=2&rft.spage=77&rft.epage=90&rft.pages=77-90&rft.issn=2062-249X&rft.eissn=2063-0212&rft_id=info:doi/10.1007/s41981-022-00247-9&rft_dat=%3Cproquest_pubme%3E2747006237%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2747006237&rft_id=info:pmid/36467977&rfr_iscdi=true |