Specificity and Breadth of the Neutralizing Antibody Response to a Live-Attenuated Tetravalent Dengue Vaccine
An effective dengue vaccine should ideally induce broadly neutralizing antibody (nAb) responses against all 4 dengue virus (DENV) serotypes. We characterized the specificity and breadth of the nAb response to TAK-003, a live-attenuated tetravalent dengue vaccine, in serum samples from phase 2 and 3...
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| Veröffentlicht in: | The Journal of infectious diseases 2022-11, Vol.226 (11), p.1959-1963 |
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| container_end_page | 1963 |
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| container_issue | 11 |
| container_start_page | 1959 |
| container_title | The Journal of infectious diseases |
| container_volume | 226 |
| creator | DeMaso, Christina R Karwal, Lovkesh Zahralban-Steele, Melissa Dominguez, David Springer, Zhang-Li Kaiser, Maima Palani, Sunil Rindfleisch, Tim Bohning, Kelly Hather, Greg Das, Subash Sharma, Mayuri Dean, Hansi J |
| description | An effective dengue vaccine should ideally induce broadly neutralizing antibody (nAb) responses against all 4 dengue virus (DENV) serotypes.
We characterized the specificity and breadth of the nAb response to TAK-003, a live-attenuated tetravalent dengue vaccine, in serum samples from phase 2 and 3 clinical trials.
Microneutralization tests using postvaccination serum showed comparable neutralization against diverse DENV-1-4 genotypes. Reporter virus particle neutralization assays after depletion of anti-DENV-2 nAbs demonstrated that the nAb response to DENV-1, -3, and -4 comprises both type-specific (TS) and cross-reactive (CR) nAbs.
Therefore, TAK-003 induces broad tetravalent TS and CR nAb responses. |
| doi_str_mv | 10.1093/infdis/jiac272 |
| format | Article |
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We characterized the specificity and breadth of the nAb response to TAK-003, a live-attenuated tetravalent dengue vaccine, in serum samples from phase 2 and 3 clinical trials.
Microneutralization tests using postvaccination serum showed comparable neutralization against diverse DENV-1-4 genotypes. Reporter virus particle neutralization assays after depletion of anti-DENV-2 nAbs demonstrated that the nAb response to DENV-1, -3, and -4 comprises both type-specific (TS) and cross-reactive (CR) nAbs.
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We characterized the specificity and breadth of the nAb response to TAK-003, a live-attenuated tetravalent dengue vaccine, in serum samples from phase 2 and 3 clinical trials.
Microneutralization tests using postvaccination serum showed comparable neutralization against diverse DENV-1-4 genotypes. Reporter virus particle neutralization assays after depletion of anti-DENV-2 nAbs demonstrated that the nAb response to DENV-1, -3, and -4 comprises both type-specific (TS) and cross-reactive (CR) nAbs.
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We characterized the specificity and breadth of the nAb response to TAK-003, a live-attenuated tetravalent dengue vaccine, in serum samples from phase 2 and 3 clinical trials.
Microneutralization tests using postvaccination serum showed comparable neutralization against diverse DENV-1-4 genotypes. Reporter virus particle neutralization assays after depletion of anti-DENV-2 nAbs demonstrated that the nAb response to DENV-1, -3, and -4 comprises both type-specific (TS) and cross-reactive (CR) nAbs.
Therefore, TAK-003 induces broad tetravalent TS and CR nAb responses.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>35771658</pmid><doi>10.1093/infdis/jiac272</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2147-557X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Antibodies, Neutralizing Antibodies, Viral Brief Report Dengue Dengue Vaccines Dengue Virus Humans Vaccines, Attenuated Vaccines, Combined |
| title | Specificity and Breadth of the Neutralizing Antibody Response to a Live-Attenuated Tetravalent Dengue Vaccine |
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