Modulation of Hippocampal Network Oscillation by PICK1-Dependent Cell Surface Expression of mGlu3 Receptors

Metabotropic glutamate receptor Type 3 (mGlu3) controls the sleep/wake architecture, which plays a role in the glutamatergic pathophysiology of schizophrenia. Interestingly, mGlu3 receptor expression is decreased in the brain of schizophrenic patients. However, little is known about the molecular me...

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Veröffentlicht in:	The Journal of neuroscience 2022-11, Vol.42 (47), p.8897-8911
Hauptverfasser:	Tuduri, Pola, Bouquier, Nathalie, Girard, Benoit, Moutin, Enora, Thouaye, Maxime, Perroy, Julie, Bertaso, Federica, Ster, Jeanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Brain slice preparation Carrier Proteins - metabolism Cell Membrane - metabolism Cell membranes Cell surface Disruption Eye movements Glutamatergic transmission Glutamic acid receptors (metabotropic) Hippocampus Hippocampus - metabolism Life Sciences Localization Male Mental disorders Mice Mimicry Molecular modelling Neurons and Cognition NREM sleep Oscillations Pathophysiology PDZ Domains Peptides Protein interaction Proteins Receptors Receptors, Metabotropic Glutamate - metabolism REM sleep Scaffolding Schizophrenia Sleep Sleep and wakefulness Theta rhythms
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