Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism

(1) Abnormally increased expression of claudin-6 in gastric cancer is considered a prognostic marker of the chromosomal unstable molecular subtype. However, a detailed molecular profile analysis of differentially expressed genes and affected pathways associated with claudin-6 increased (Cldn6 ) expr...

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Veröffentlicht in:	International journal of molecular sciences 2022-11, Vol.23 (22), p.13977
Hauptverfasser:	Dwivedi, Sanyog, Hernández-Montes, Georgina, Montaño, Luis Felipe, Rendón-Huerta, Erika Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Apolipoprotein C-III Cholesterol Claudins Epstein-Barr virus Gastric cancer Gene expression Genes Genotype & phenotype Hepatocyte Nuclear Factor 1-alpha Hepatocyte nuclear factor 4 Hepatocyte Nuclear Factor 4 - genetics Humans Intracellular Signaling Peptides and Proteins Lipid metabolism Low density lipoprotein Medical prognosis Metabolism Mutation Neoplasm Proteins p53 Protein Proteins Steroidogenic acute regulatory protein Sterol O-acyltransferase Stomach Neoplasms - genetics Survival analysis Transcription factors Tumors
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