Genetic Addiction Risk Severity Assessment Identifies Polymorphic Reward Genes as Antecedents to Reward Deficiency Syndrome (RDS) Hypodopaminergia's Effect on Addictive and Non-Addictive Behaviors in a Nuclear Family

This case series presents the novel genetic addiction risk score (GARS), which shows a high prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues expressing a hypodopaminergic antecedent. The family consists of a m...

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Veröffentlicht in:Journal of personalized medicine 2022-11, Vol.12 (11), p.1864
Hauptverfasser: Dennen, Catherine A, Blum, Kenneth, Bowirrat, Abdalla, Thanos, Panayotis K, Elman, Igor, Ceccanti, Mauro, Badgaiyan, Rajendra D, McLaughlin, Thomas, Gupta, Ashim, Bajaj, Anish, Baron, David, Downs, B William, Bagchi, Debasis, Gold, Mark S
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container_issue 11
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container_title Journal of personalized medicine
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creator Dennen, Catherine A
Blum, Kenneth
Bowirrat, Abdalla
Thanos, Panayotis K
Elman, Igor
Ceccanti, Mauro
Badgaiyan, Rajendra D
McLaughlin, Thomas
Gupta, Ashim
Bajaj, Anish
Baron, David
Downs, B William
Bagchi, Debasis
Gold, Mark S
description This case series presents the novel genetic addiction risk score (GARS), which shows a high prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues expressing a hypodopaminergic antecedent. The family consists of a mother, father, son, and daughter. The mother experienced issues with focus, memory, anger, and amotivational syndrome. The father experienced weight issues and depression. The son experienced heavy drinking, along with some drug abuse and anxiety. The daughter experienced depression, lethargy, brain fog, focus issues, and anxiety, among others. A major clinical outcome of the results presented to the family members helped reduce personal guilt and augment potential hope for future healing. Our laboratory's prior research established that carriers of four or more alleles measured by GARS ( , , , , , , and ) are predictive of the addiction severity index (ASI) for drug abuse, and carriers of seven or more alleles are predictive of severe alcoholism. This generational case series shows the impact that genetic information has on reducing stigma and guilt in a nuclear family struggling with RDS behaviors. The futuristic plan is to introduce an appropriate DNA-guided "pro-dopamine regulator" into the recovery and enhancement of life.
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subjects Addictions
Addictive behaviors
Alcohol use
Alcoholism
Alleles
Anxiety
Behavior
Communication
Dopamine
Dopamine D1 receptors
Dopamine D4 receptors
Drinking behavior
Drug abuse
Drug use
Epigenetics
Genes
Health risk assessment
Impulsivity
Laboratories
Mental depression
Mental disorders
Narcotics
Nuclear family
Personality
Polymorphism
Precision medicine
Reinforcement
Respiratory distress syndrome
Stress
title Genetic Addiction Risk Severity Assessment Identifies Polymorphic Reward Genes as Antecedents to Reward Deficiency Syndrome (RDS) Hypodopaminergia's Effect on Addictive and Non-Addictive Behaviors in a Nuclear Family
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