Tiron Has Negative Effects on Osteogenic Differentiation via Mitochondrial Dysfunction in Human Periosteum-Derived Cells

Tiron is a potent antioxidant that counters the pathological effects of reactive oxygen species (ROS) production due to oxidative stress in various cell types. We examined the effects of tiron on mitochondrial function and osteoblastic differentiation in human periosteum-derived cells (hPDCs). Tiron...

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Veröffentlicht in:	International journal of molecular sciences 2022-11, Vol.23 (22), p.14040
Hauptverfasser:	Park, Jin-Ho, Koh, Eun-Byeol, Seo, Young-Jin, Oh, Hye-Seong, Won, Ju-Yeong, Hwang, Sun-Chul, Byun, June-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt Aging Alizarin Alkaline phosphatase Alzheimer's disease Antioxidants Apoptosis Cell culture Cell differentiation Differentiation (biology) Galactosidase Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Metabolism Mineralization Mitochondria Osteoblastogenesis Osteoblasts Osteogenesis Oxidative stress Oxygen consumption Pathological effects Periosteum Physiology Reactive Oxygen Species Senescence Stem cells β-Galactosidase
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