A MWCNTs-COOH/PSS nanocomposite–modified screen-printed electrode for the determination of synthetic phenolic antioxidants by HPLC with amperometric detection
New sensing platforms based on screen-printed carbon electrodes modified with composites based on polystyrene sulfonate and oxidized multi-walled carbon nanotubes (PSS/MWCNTs-COOH/SPCE) have been used to develop a novel HPLC method with electrochemical detection (ECD) for the determination of the mo...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2022-12, Vol.189 (12), p.469, Article 469 |
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| container_title | Mikrochimica acta (1966) |
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| creator | Abad-Gil, Lucía García-Ríos, Mayte Isabel-Cabrera, Carmen Gismera, M. Jesús Sevilla, M. Teresa Procopio, Jesús R. |
| description | New sensing platforms based on screen-printed carbon electrodes modified with composites based on polystyrene sulfonate and oxidized multi-walled carbon nanotubes (PSS/MWCNTs-COOH/SPCE) have been used to develop a novel HPLC method with electrochemical detection (ECD) for the determination of the most used synthetic phenolic antioxidants in cosmetics: butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), tert-butylhydroquinone (TBHQ) and propyl gallate (PG). Optimal separation conditions were achieved using methanol: 0.10 mol L
−1
acetate solution at pH 6 as mobile phase with a gradient elution program from 60 to 90% of methanol percentage in 15 min. The electrochemical detection was carried out in amperometric mode using the PSS/MWCNTs-COOH/SPCE at + 0.80 V vs. Ag. Under these optimal separation and detection conditions, the limits of detection (LOD) were between 0.11 and 0.25 mg L
−1
. These LOD values were better, especially for BHT, than those previously published in other HPLC methods. Linear ranges from 0.37 mg L
−1
, 0.83 mg L
−1
, 0.69 mg L
−1
and 0.56 mg L
−1
to 10 mg L
−1
were obtained for PG, TBHQ, BHA and BHT, respectively. RSD values equal or lower than 5% and 8% were achieved for repeatability and reproducibility, respectively. The HPLC-ECD method was successfully applied to analyze different cosmetic samples. Recovery values within 83–109% were obtained in the validation studies.
Graphical Abstract |
| doi_str_mv | 10.1007/s00604-022-05552-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9691489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A727815214</galeid><sourcerecordid>A727815214</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-43dd2a7180a510390172714e4f96a0cd41fed44363d80849c2a9e09edbedb5413</originalsourceid><addsrcrecordid>eNp9UttuEzEQXSEQDYUf4AFZ4nlb2-u9vSBFq9IgBVKpRTxajj2buNq1g-0Aees_8AN8G1_ChJSWSgjZ0tgzZ47m2CfLXjJ6wiitTyOlFRU55TynZVnyvH6UTZgoqrykdfE4m1DKq7yoan6UPYvxmlJWV1w8zY6KSnBeMzbJfkzJ-0_dh6uYd4vF7PTi8pI45bz248ZHm-DnzffRG9tbMCTqAODyTbAu4RUG0Cl4A6T3gaQ1EAMJwmidStY74nsSdw7zyWqyWYPzAx6Uw-I3azBGstyR2cW8I19tWhM1biD4EVJA2J5K72meZ096NUR4cRuPs49vz666WT5fnL_rpvNcl4KlXBTGcFWzhqqS0aJFqShQgOjbSlFtBOvBCHybwjS0Ea3mqgXaglniRobiOHtz4N1slyMYDS4FNUgUO6qwk15Z-bDi7Fqu_BfZVi0TTYsEr28Jgv-8hZjktd8GhzNLXhctvnzViHvUSg0gres9kunRRi2nOHHDSs72qJN_oHAZGK32DnqL-QcN_NCgg48xQH83OKNybxZ5MItEs8jfZpE1Nr36W_Jdyx93IKA4AOL-z1cQ7iX9h_YXIOvNJw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2739762684</pqid></control><display><type>article</type><title>A MWCNTs-COOH/PSS nanocomposite–modified screen-printed electrode for the determination of synthetic phenolic antioxidants by HPLC with amperometric detection</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Abad-Gil, Lucía ; García-Ríos, Mayte ; Isabel-Cabrera, Carmen ; Gismera, M. Jesús ; Sevilla, M. Teresa ; Procopio, Jesús R.</creator><creatorcontrib>Abad-Gil, Lucía ; García-Ríos, Mayte ; Isabel-Cabrera, Carmen ; Gismera, M. Jesús ; Sevilla, M. Teresa ; Procopio, Jesús R.</creatorcontrib><description>New sensing platforms based on screen-printed carbon electrodes modified with composites based on polystyrene sulfonate and oxidized multi-walled carbon nanotubes (PSS/MWCNTs-COOH/SPCE) have been used to develop a novel HPLC method with electrochemical detection (ECD) for the determination of the most used synthetic phenolic antioxidants in cosmetics: butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), tert-butylhydroquinone (TBHQ) and propyl gallate (PG). Optimal separation conditions were achieved using methanol: 0.10 mol L
−1
acetate solution at pH 6 as mobile phase with a gradient elution program from 60 to 90% of methanol percentage in 15 min. The electrochemical detection was carried out in amperometric mode using the PSS/MWCNTs-COOH/SPCE at + 0.80 V vs. Ag. Under these optimal separation and detection conditions, the limits of detection (LOD) were between 0.11 and 0.25 mg L
−1
. These LOD values were better, especially for BHT, than those previously published in other HPLC methods. Linear ranges from 0.37 mg L
−1
, 0.83 mg L
−1
, 0.69 mg L
−1
and 0.56 mg L
−1
to 10 mg L
−1
were obtained for PG, TBHQ, BHA and BHT, respectively. RSD values equal or lower than 5% and 8% were achieved for repeatability and reproducibility, respectively. The HPLC-ECD method was successfully applied to analyze different cosmetic samples. Recovery values within 83–109% were obtained in the validation studies.
Graphical Abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-022-05552-7</identifier><identifier>PMID: 36422711</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analysis ; Analytical Chemistry ; Antioxidants ; Butylated Hydroxyanisole - analysis ; Butylated Hydroxytoluene - analysis ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chromatography, High Pressure Liquid - methods ; Cosmetics ; Electric properties ; Electrical measurement ; Electrochemical analysis ; Electrodes ; High performance liquid chromatography ; Ions ; Methanol ; Microengineering ; Multi wall carbon nanotubes ; Nanochemistry ; Nanocomposites ; Nanotechnology ; Nanotubes ; Nanotubes, Carbon ; Original Paper ; Phenols ; Polystyrene resins ; Propyl Gallate - analysis ; Reproducibility ; Reproducibility of Results ; Separation</subject><ispartof>Mikrochimica acta (1966), 2022-12, Vol.189 (12), p.469, Article 469</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-43dd2a7180a510390172714e4f96a0cd41fed44363d80849c2a9e09edbedb5413</citedby><cites>FETCH-LOGICAL-c541t-43dd2a7180a510390172714e4f96a0cd41fed44363d80849c2a9e09edbedb5413</cites><orcidid>0000-0002-6344-0148 ; 0000-0003-1200-8408 ; 0000-0002-0296-8053 ; 0000-0003-0016-9714</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-022-05552-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-022-05552-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36422711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abad-Gil, Lucía</creatorcontrib><creatorcontrib>García-Ríos, Mayte</creatorcontrib><creatorcontrib>Isabel-Cabrera, Carmen</creatorcontrib><creatorcontrib>Gismera, M. Jesús</creatorcontrib><creatorcontrib>Sevilla, M. Teresa</creatorcontrib><creatorcontrib>Procopio, Jesús R.</creatorcontrib><title>A MWCNTs-COOH/PSS nanocomposite–modified screen-printed electrode for the determination of synthetic phenolic antioxidants by HPLC with amperometric detection</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>New sensing platforms based on screen-printed carbon electrodes modified with composites based on polystyrene sulfonate and oxidized multi-walled carbon nanotubes (PSS/MWCNTs-COOH/SPCE) have been used to develop a novel HPLC method with electrochemical detection (ECD) for the determination of the most used synthetic phenolic antioxidants in cosmetics: butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), tert-butylhydroquinone (TBHQ) and propyl gallate (PG). Optimal separation conditions were achieved using methanol: 0.10 mol L
−1
acetate solution at pH 6 as mobile phase with a gradient elution program from 60 to 90% of methanol percentage in 15 min. The electrochemical detection was carried out in amperometric mode using the PSS/MWCNTs-COOH/SPCE at + 0.80 V vs. Ag. Under these optimal separation and detection conditions, the limits of detection (LOD) were between 0.11 and 0.25 mg L
−1
. These LOD values were better, especially for BHT, than those previously published in other HPLC methods. Linear ranges from 0.37 mg L
−1
, 0.83 mg L
−1
, 0.69 mg L
−1
and 0.56 mg L
−1
to 10 mg L
−1
were obtained for PG, TBHQ, BHA and BHT, respectively. RSD values equal or lower than 5% and 8% were achieved for repeatability and reproducibility, respectively. The HPLC-ECD method was successfully applied to analyze different cosmetic samples. Recovery values within 83–109% were obtained in the validation studies.
Graphical Abstract</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Antioxidants</subject><subject>Butylated Hydroxyanisole - analysis</subject><subject>Butylated Hydroxytoluene - analysis</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Cosmetics</subject><subject>Electric properties</subject><subject>Electrical measurement</subject><subject>Electrochemical analysis</subject><subject>Electrodes</subject><subject>High performance liquid chromatography</subject><subject>Ions</subject><subject>Methanol</subject><subject>Microengineering</subject><subject>Multi wall carbon nanotubes</subject><subject>Nanochemistry</subject><subject>Nanocomposites</subject><subject>Nanotechnology</subject><subject>Nanotubes</subject><subject>Nanotubes, Carbon</subject><subject>Original Paper</subject><subject>Phenols</subject><subject>Polystyrene resins</subject><subject>Propyl Gallate - analysis</subject><subject>Reproducibility</subject><subject>Reproducibility of Results</subject><subject>Separation</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UttuEzEQXSEQDYUf4AFZ4nlb2-u9vSBFq9IgBVKpRTxajj2buNq1g-0Aees_8AN8G1_ChJSWSgjZ0tgzZ47m2CfLXjJ6wiitTyOlFRU55TynZVnyvH6UTZgoqrykdfE4m1DKq7yoan6UPYvxmlJWV1w8zY6KSnBeMzbJfkzJ-0_dh6uYd4vF7PTi8pI45bz248ZHm-DnzffRG9tbMCTqAODyTbAu4RUG0Cl4A6T3gaQ1EAMJwmidStY74nsSdw7zyWqyWYPzAx6Uw-I3azBGstyR2cW8I19tWhM1biD4EVJA2J5K72meZ096NUR4cRuPs49vz666WT5fnL_rpvNcl4KlXBTGcFWzhqqS0aJFqShQgOjbSlFtBOvBCHybwjS0Ea3mqgXaglniRobiOHtz4N1slyMYDS4FNUgUO6qwk15Z-bDi7Fqu_BfZVi0TTYsEr28Jgv-8hZjktd8GhzNLXhctvnzViHvUSg0gres9kunRRi2nOHHDSs72qJN_oHAZGK32DnqL-QcN_NCgg48xQH83OKNybxZ5MItEs8jfZpE1Nr36W_Jdyx93IKA4AOL-z1cQ7iX9h_YXIOvNJw</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Abad-Gil, Lucía</creator><creator>García-Ríos, Mayte</creator><creator>Isabel-Cabrera, Carmen</creator><creator>Gismera, M. 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Jesús</creatorcontrib><creatorcontrib>Sevilla, M. Teresa</creatorcontrib><creatorcontrib>Procopio, Jesús R.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abad-Gil, Lucía</au><au>García-Ríos, Mayte</au><au>Isabel-Cabrera, Carmen</au><au>Gismera, M. Jesús</au><au>Sevilla, M. Teresa</au><au>Procopio, Jesús R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A MWCNTs-COOH/PSS nanocomposite–modified screen-printed electrode for the determination of synthetic phenolic antioxidants by HPLC with amperometric detection</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>189</volume><issue>12</issue><spage>469</spage><pages>469-</pages><artnum>469</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>New sensing platforms based on screen-printed carbon electrodes modified with composites based on polystyrene sulfonate and oxidized multi-walled carbon nanotubes (PSS/MWCNTs-COOH/SPCE) have been used to develop a novel HPLC method with electrochemical detection (ECD) for the determination of the most used synthetic phenolic antioxidants in cosmetics: butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), tert-butylhydroquinone (TBHQ) and propyl gallate (PG). Optimal separation conditions were achieved using methanol: 0.10 mol L
−1
acetate solution at pH 6 as mobile phase with a gradient elution program from 60 to 90% of methanol percentage in 15 min. The electrochemical detection was carried out in amperometric mode using the PSS/MWCNTs-COOH/SPCE at + 0.80 V vs. Ag. Under these optimal separation and detection conditions, the limits of detection (LOD) were between 0.11 and 0.25 mg L
−1
. These LOD values were better, especially for BHT, than those previously published in other HPLC methods. Linear ranges from 0.37 mg L
−1
, 0.83 mg L
−1
, 0.69 mg L
−1
and 0.56 mg L
−1
to 10 mg L
−1
were obtained for PG, TBHQ, BHA and BHT, respectively. RSD values equal or lower than 5% and 8% were achieved for repeatability and reproducibility, respectively. The HPLC-ECD method was successfully applied to analyze different cosmetic samples. Recovery values within 83–109% were obtained in the validation studies.
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| ispartof | Mikrochimica acta (1966), 2022-12, Vol.189 (12), p.469, Article 469 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Analysis Analytical Chemistry Antioxidants Butylated Hydroxyanisole - analysis Butylated Hydroxytoluene - analysis Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography, High Pressure Liquid - methods Cosmetics Electric properties Electrical measurement Electrochemical analysis Electrodes High performance liquid chromatography Ions Methanol Microengineering Multi wall carbon nanotubes Nanochemistry Nanocomposites Nanotechnology Nanotubes Nanotubes, Carbon Original Paper Phenols Polystyrene resins Propyl Gallate - analysis Reproducibility Reproducibility of Results Separation |
| title | A MWCNTs-COOH/PSS nanocomposite–modified screen-printed electrode for the determination of synthetic phenolic antioxidants by HPLC with amperometric detection |
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