Metal–Organic Framework-Based Composites for the Detection and Monitoring of Pharmaceutical Compounds in Biological and Environmental Matrices
The production of synthetic drugs is considered a huge milestone in the healthcare sector, transforming the overall health, aging, and lifestyle of the general population. Due to the surge in production and consumption, pharmaceutical drugs have emerged as potential environmental pollutants that are...
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creator | Rizwan, Muhammad Selvanathan, Vidhya Rasool, Atta Qureshi, Muhammad Anees ur Rehman Iqbal, Dure Najaf Kanwal, Qudsia Shafqat, Syed Salman Rasheed, Tahir Bilal, Muhammad |
description | The production of synthetic drugs is considered a huge milestone in the healthcare sector, transforming the overall health, aging, and lifestyle of the general population. Due to the surge in production and consumption, pharmaceutical drugs have emerged as potential environmental pollutants that are toxic with low biodegradability. Traditional chromatographic techniques in practice are time-consuming and expensive, despite good precision. Alternatively, electroanalytical techniques are recently identified to be selective, rapid, sensitive, and easier for drug detection. Metal–organic frameworks (MOFs) are known for their intrinsic porous nature, high surface area, and diversity in structural design that provides credible drug-sensing capacities. Long-term reusability and maintaining chemo-structural integrity are major challenges that are countered by ligand–metal combinations, optimization of synthetic conditions, functionalization, and direct MOFs growth over the electrode surface. Moreover, chemical instability and lower conductivities limited the mass commercialization of MOF-based materials in the fields of biosensing, imaging, drug release, therapeutics, and clinical diagnostics. This review is dedicated to analyzing the various combinations of MOFs used for electrochemical detection of pharmaceutical drugs, comprising antibiotics, analgesics, anticancer, antituberculosis, and veterinary drugs. Furthermore, the relationship between the composition, morphology and structural properties of MOFs with their detection capabilities for each drug species is elucidated. |
doi_str_mv | 10.1007/s11270-022-05904-2 |
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subjects | Aging Analgesics Antibiotics Atmospheric Protection/Air Quality Control/Air Pollution Biodegradability Biodegradation Biosensors Chromatography Climate Change/Climate Change Impacts Commercialization Detection Drug development Drugs Earth and Environmental Science Electric properties Electrochemical analysis Electrochemistry Environment Environmental monitoring Hydrogeology Marketing Metal-organic frameworks Metals Optimization Pharmaceuticals Pollutants Soil Science & Conservation Structural design Structural engineering Structural integrity Surface stability Veterinary drugs Veterinary medicine Water Quality/Water Pollution |
title | Metal–Organic Framework-Based Composites for the Detection and Monitoring of Pharmaceutical Compounds in Biological and Environmental Matrices |
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