Coenzyme Q10 Supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions
Oxidative stress (OS) is brought on by heat stress (HS), which weakens antioxidant defense and initiates OS. Since mitochondria are the primary source of reactive oxygen species (ROS), HS-mediated OS may be lessened by targeting mitochondria with particular antioxidants. The purpose of this study wa...
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| Veröffentlicht in: | Veterinary research communications 2022-12, Vol.46 (4), p.1245-1257 |
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| creator | El-Sherbiny, Hossam R. Abdelnaby, Elshymaa A. El-Shahat, K. H. Salem, Noha Y. Ramadan, Eman S. Yehia, Shimaa G. Fathi, Mohamed |
| description | Oxidative stress (OS) is brought on by heat stress (HS), which weakens antioxidant defense and initiates OS. Since mitochondria are the primary source of reactive oxygen species (ROS), HS-mediated OS may be lessened by targeting mitochondria with particular antioxidants. The purpose of this study was to investigate the effect of oral coenzyme Q10 (CoQ10) supplementation on the reproductive performance of goat bucks under HS conditions. Ten mature bucks were randomly separated into two groups and housed in an environment with a high-temperature humidity index (THI: 88.3 to 94.8; summer season). The first group (
n
= 5) got the baseline diet while the second group (
n
= 5) received supplemental oral CoQ10 (3 mg/kg BW; CoQ10 group) daily for six weeks. Testicular blood flow parameters (TBF), testicular volume (TV) and echogenicity (TE), nitric oxide (NO), seminal alanine aminotransferase (ALT) and catalase (CAT) activities, total antioxidant capacity (TAC), malondialdehyde (MDA) content, and semen quality traits were all measured. The examinations started a week before (W-1), on the first supplementation day (W0), and weekly for eight consecutive weeks (W1-W8). There were marked
(P
|
| doi_str_mv | 10.1007/s11259-022-09991-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9684261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2739324675</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-3e812af7cfe35efc3ea3b7bd779c6ff51da4155c7a726e4a97cc6bcbab1314b23</originalsourceid><addsrcrecordid>eNp9kkGL1TAUhYsozpvRP-Aq4MbFVJOmbZqNIA8dhQERdR1u09vXjE3SSZqHz1_nTzNv3qDowtUNyXdOLodTFM8YfckoFa8iY1UjS1pVJZVSsrJ7UGxYI3gp6rp9WGwoa5tS8I6eFecx3lBKZUf54-KMt7TuOBeb4ufWo_txsEg-MUo-p2WZ0aJbYTXeEXQTOI2RrBhXo9MMgez9nDIObiATWj8cHFij4yUJuAQ_JL2aPZLJB-sd5uu4YLDkNsFs1sPlnS6iNQ7mfM6_fDdDnkTDAjoTxDiy87CSPulvkSQ3YCAxWZvH5FcyJWsGor0bzHHF-KR4NMIc8en9vCi-vnv7Zfu-vP549WH75rrUdcPWkmPHKhiFHpE3OGqOwHvRD0JI3Y5jwwaoWdNoAaJqsQYptG573UPPOKv7il8Ur0--S-otDjpnFGBWSzAWwkF5MOrvF2cmtfN7JduurlqWDV7cGwR_m3KeypqocZ7BoU9RVYJKymTXHNHn_6A3PoWc2JHikld1K5pMVSdKBx9jwPH3MoyqY0HUqSAqF0TdFUR1WcRPophht8Pwx_o_ql_nPMRC</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2739324675</pqid></control><display><type>article</type><title>Coenzyme Q10 Supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions</title><source>SpringerLink Journals</source><creator>El-Sherbiny, Hossam R. ; Abdelnaby, Elshymaa A. ; El-Shahat, K. H. ; Salem, Noha Y. ; Ramadan, Eman S. ; Yehia, Shimaa G. ; Fathi, Mohamed</creator><creatorcontrib>El-Sherbiny, Hossam R. ; Abdelnaby, Elshymaa A. ; El-Shahat, K. H. ; Salem, Noha Y. ; Ramadan, Eman S. ; Yehia, Shimaa G. ; Fathi, Mohamed</creatorcontrib><description>Oxidative stress (OS) is brought on by heat stress (HS), which weakens antioxidant defense and initiates OS. Since mitochondria are the primary source of reactive oxygen species (ROS), HS-mediated OS may be lessened by targeting mitochondria with particular antioxidants. The purpose of this study was to investigate the effect of oral coenzyme Q10 (CoQ10) supplementation on the reproductive performance of goat bucks under HS conditions. Ten mature bucks were randomly separated into two groups and housed in an environment with a high-temperature humidity index (THI: 88.3 to 94.8; summer season). The first group (
n
= 5) got the baseline diet while the second group (
n
= 5) received supplemental oral CoQ10 (3 mg/kg BW; CoQ10 group) daily for six weeks. Testicular blood flow parameters (TBF), testicular volume (TV) and echogenicity (TE), nitric oxide (NO), seminal alanine aminotransferase (ALT) and catalase (CAT) activities, total antioxidant capacity (TAC), malondialdehyde (MDA) content, and semen quality traits were all measured. The examinations started a week before (W-1), on the first supplementation day (W0), and weekly for eight consecutive weeks (W1-W8). There were marked
(P
<
0.05)
increases in TBF (W3-W6) and TV, and a decrease in TE (W3-W5) in the CoQ10 group compared to the CON group. Similarly, testosterone (T) and NO levels (W3-W5) in the CoQ10 group were higher
(P
<
0.05)
than those of the control group. The CoQ10 group demonstrated significant
(P
< 0.05) increases in seminal CAT (W4-W8) and TAC (W2-W6) activities and decreases in ALT (W4-W7) activity and MDA (W5-W8) concentration as compared to the control group. The CoQ10 group showed improvements
(P
< 0.05) at W3-W6 for sperm progressive motility, viability, and normal morphology and at W6-W8 for sperm concentration. In conclusion, oral CoQ10 supplementation improved testicular hemodynamics, testosterone production, semen quality, and antioxidant capacity in goat bucks during summer heat stress conditions.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-022-09991-8</identifier><identifier>PMID: 36048337</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Alanine transaminase ; Antioxidants ; Biomedical and Life Sciences ; Blood flow ; Catalase ; Coenzyme Q10 ; Dietary supplements ; Hemodynamics ; Life Sciences ; Mitochondria ; Nitric oxide ; Oxidative stress ; Reactive oxygen species ; Semen ; Sperm ; Summer ; Testes ; Testosterone ; Veterinary Medicine/Veterinary Science ; Zoology</subject><ispartof>Veterinary research communications, 2022-12, Vol.46 (4), p.1245-1257</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-3e812af7cfe35efc3ea3b7bd779c6ff51da4155c7a726e4a97cc6bcbab1314b23</citedby><cites>FETCH-LOGICAL-c451t-3e812af7cfe35efc3ea3b7bd779c6ff51da4155c7a726e4a97cc6bcbab1314b23</cites><orcidid>0000-0003-0069-9926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11259-022-09991-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11259-022-09991-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>El-Sherbiny, Hossam R.</creatorcontrib><creatorcontrib>Abdelnaby, Elshymaa A.</creatorcontrib><creatorcontrib>El-Shahat, K. H.</creatorcontrib><creatorcontrib>Salem, Noha Y.</creatorcontrib><creatorcontrib>Ramadan, Eman S.</creatorcontrib><creatorcontrib>Yehia, Shimaa G.</creatorcontrib><creatorcontrib>Fathi, Mohamed</creatorcontrib><title>Coenzyme Q10 Supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><description>Oxidative stress (OS) is brought on by heat stress (HS), which weakens antioxidant defense and initiates OS. Since mitochondria are the primary source of reactive oxygen species (ROS), HS-mediated OS may be lessened by targeting mitochondria with particular antioxidants. The purpose of this study was to investigate the effect of oral coenzyme Q10 (CoQ10) supplementation on the reproductive performance of goat bucks under HS conditions. Ten mature bucks were randomly separated into two groups and housed in an environment with a high-temperature humidity index (THI: 88.3 to 94.8; summer season). The first group (
n
= 5) got the baseline diet while the second group (
n
= 5) received supplemental oral CoQ10 (3 mg/kg BW; CoQ10 group) daily for six weeks. Testicular blood flow parameters (TBF), testicular volume (TV) and echogenicity (TE), nitric oxide (NO), seminal alanine aminotransferase (ALT) and catalase (CAT) activities, total antioxidant capacity (TAC), malondialdehyde (MDA) content, and semen quality traits were all measured. The examinations started a week before (W-1), on the first supplementation day (W0), and weekly for eight consecutive weeks (W1-W8). There were marked
(P
<
0.05)
increases in TBF (W3-W6) and TV, and a decrease in TE (W3-W5) in the CoQ10 group compared to the CON group. Similarly, testosterone (T) and NO levels (W3-W5) in the CoQ10 group were higher
(P
<
0.05)
than those of the control group. The CoQ10 group demonstrated significant
(P
< 0.05) increases in seminal CAT (W4-W8) and TAC (W2-W6) activities and decreases in ALT (W4-W7) activity and MDA (W5-W8) concentration as compared to the control group. The CoQ10 group showed improvements
(P
< 0.05) at W3-W6 for sperm progressive motility, viability, and normal morphology and at W6-W8 for sperm concentration. In conclusion, oral CoQ10 supplementation improved testicular hemodynamics, testosterone production, semen quality, and antioxidant capacity in goat bucks during summer heat stress conditions.</description><subject>Alanine transaminase</subject><subject>Antioxidants</subject><subject>Biomedical and Life Sciences</subject><subject>Blood flow</subject><subject>Catalase</subject><subject>Coenzyme Q10</subject><subject>Dietary supplements</subject><subject>Hemodynamics</subject><subject>Life Sciences</subject><subject>Mitochondria</subject><subject>Nitric oxide</subject><subject>Oxidative stress</subject><subject>Reactive oxygen species</subject><subject>Semen</subject><subject>Sperm</subject><subject>Summer</subject><subject>Testes</subject><subject>Testosterone</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Zoology</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kkGL1TAUhYsozpvRP-Aq4MbFVJOmbZqNIA8dhQERdR1u09vXjE3SSZqHz1_nTzNv3qDowtUNyXdOLodTFM8YfckoFa8iY1UjS1pVJZVSsrJ7UGxYI3gp6rp9WGwoa5tS8I6eFecx3lBKZUf54-KMt7TuOBeb4ufWo_txsEg-MUo-p2WZ0aJbYTXeEXQTOI2RrBhXo9MMgez9nDIObiATWj8cHFij4yUJuAQ_JL2aPZLJB-sd5uu4YLDkNsFs1sPlnS6iNQ7mfM6_fDdDnkTDAjoTxDiy87CSPulvkSQ3YCAxWZvH5FcyJWsGor0bzHHF-KR4NMIc8en9vCi-vnv7Zfu-vP549WH75rrUdcPWkmPHKhiFHpE3OGqOwHvRD0JI3Y5jwwaoWdNoAaJqsQYptG573UPPOKv7il8Ur0--S-otDjpnFGBWSzAWwkF5MOrvF2cmtfN7JduurlqWDV7cGwR_m3KeypqocZ7BoU9RVYJKymTXHNHn_6A3PoWc2JHikld1K5pMVSdKBx9jwPH3MoyqY0HUqSAqF0TdFUR1WcRPophht8Pwx_o_ql_nPMRC</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>El-Sherbiny, Hossam R.</creator><creator>Abdelnaby, Elshymaa A.</creator><creator>El-Shahat, K. H.</creator><creator>Salem, Noha Y.</creator><creator>Ramadan, Eman S.</creator><creator>Yehia, Shimaa G.</creator><creator>Fathi, Mohamed</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0069-9926</orcidid></search><sort><creationdate>20221201</creationdate><title>Coenzyme Q10 Supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions</title><author>El-Sherbiny, Hossam R. ; Abdelnaby, Elshymaa A. ; El-Shahat, K. H. ; Salem, Noha Y. ; Ramadan, Eman S. ; Yehia, Shimaa G. ; Fathi, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-3e812af7cfe35efc3ea3b7bd779c6ff51da4155c7a726e4a97cc6bcbab1314b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alanine transaminase</topic><topic>Antioxidants</topic><topic>Biomedical and Life Sciences</topic><topic>Blood flow</topic><topic>Catalase</topic><topic>Coenzyme Q10</topic><topic>Dietary supplements</topic><topic>Hemodynamics</topic><topic>Life Sciences</topic><topic>Mitochondria</topic><topic>Nitric oxide</topic><topic>Oxidative stress</topic><topic>Reactive oxygen species</topic><topic>Semen</topic><topic>Sperm</topic><topic>Summer</topic><topic>Testes</topic><topic>Testosterone</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Sherbiny, Hossam R.</creatorcontrib><creatorcontrib>Abdelnaby, Elshymaa A.</creatorcontrib><creatorcontrib>El-Shahat, K. H.</creatorcontrib><creatorcontrib>Salem, Noha Y.</creatorcontrib><creatorcontrib>Ramadan, Eman S.</creatorcontrib><creatorcontrib>Yehia, Shimaa G.</creatorcontrib><creatorcontrib>Fathi, Mohamed</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Sherbiny, Hossam R.</au><au>Abdelnaby, Elshymaa A.</au><au>El-Shahat, K. H.</au><au>Salem, Noha Y.</au><au>Ramadan, Eman S.</au><au>Yehia, Shimaa G.</au><au>Fathi, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coenzyme Q10 Supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions</atitle><jtitle>Veterinary research communications</jtitle><stitle>Vet Res Commun</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>46</volume><issue>4</issue><spage>1245</spage><epage>1257</epage><pages>1245-1257</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>Oxidative stress (OS) is brought on by heat stress (HS), which weakens antioxidant defense and initiates OS. Since mitochondria are the primary source of reactive oxygen species (ROS), HS-mediated OS may be lessened by targeting mitochondria with particular antioxidants. The purpose of this study was to investigate the effect of oral coenzyme Q10 (CoQ10) supplementation on the reproductive performance of goat bucks under HS conditions. Ten mature bucks were randomly separated into two groups and housed in an environment with a high-temperature humidity index (THI: 88.3 to 94.8; summer season). The first group (
n
= 5) got the baseline diet while the second group (
n
= 5) received supplemental oral CoQ10 (3 mg/kg BW; CoQ10 group) daily for six weeks. Testicular blood flow parameters (TBF), testicular volume (TV) and echogenicity (TE), nitric oxide (NO), seminal alanine aminotransferase (ALT) and catalase (CAT) activities, total antioxidant capacity (TAC), malondialdehyde (MDA) content, and semen quality traits were all measured. The examinations started a week before (W-1), on the first supplementation day (W0), and weekly for eight consecutive weeks (W1-W8). There were marked
(P
<
0.05)
increases in TBF (W3-W6) and TV, and a decrease in TE (W3-W5) in the CoQ10 group compared to the CON group. Similarly, testosterone (T) and NO levels (W3-W5) in the CoQ10 group were higher
(P
<
0.05)
than those of the control group. The CoQ10 group demonstrated significant
(P
< 0.05) increases in seminal CAT (W4-W8) and TAC (W2-W6) activities and decreases in ALT (W4-W7) activity and MDA (W5-W8) concentration as compared to the control group. The CoQ10 group showed improvements
(P
< 0.05) at W3-W6 for sperm progressive motility, viability, and normal morphology and at W6-W8 for sperm concentration. In conclusion, oral CoQ10 supplementation improved testicular hemodynamics, testosterone production, semen quality, and antioxidant capacity in goat bucks during summer heat stress conditions.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>36048337</pmid><doi>10.1007/s11259-022-09991-8</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-0069-9926</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Veterinary research communications, 2022-12, Vol.46 (4), p.1245-1257 |
| issn | 0165-7380 1573-7446 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9684261 |
| source | SpringerLink Journals |
| subjects | Alanine transaminase Antioxidants Biomedical and Life Sciences Blood flow Catalase Coenzyme Q10 Dietary supplements Hemodynamics Life Sciences Mitochondria Nitric oxide Oxidative stress Reactive oxygen species Semen Sperm Summer Testes Testosterone Veterinary Medicine/Veterinary Science Zoology |
| title | Coenzyme Q10 Supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions |
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