Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions

Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of the protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved under positive se...

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Veröffentlicht in:	Science advances 2022-11, Vol.8 (47), p.eadd7540-eadd7540
Hauptverfasser:	Jacquet, Stéphanie, Culbertson, Michelle, Zhang, Chi, El Filali, Adil, De La Myre Mory, Clément, Pons, Jean-Baptiste, Filippi-Codaccioni, Ondine, Lauterbur, M Elise, Ngoubangoye, Barthélémy, Duhayer, Jeanne, Verez, Clément, Park, Chorong, Dahoui, Clara, Carey, Clayton M, Brennan, Greg, Enard, David, Cimarelli, Andrea, Rothenburg, Stefan, Elde, Nels C, Pontier, Dominique, Etienne, Lucie
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Evolutionary Biology Life Sciences SciAdv r-articles Virology
Online-Zugang:	Volltext
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