Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method

The virulence of the CDC1551 strain of Mycobacterium tuberculosis was compared to that of H37Rv in a rabbit inhalation model. While rabbits that inhaled the two strains produced equal numbers of grossly visible primary tubercles, CDC1551 tubercles were smaller and contained fewer bacilli than H37Rv...

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Veröffentlicht in:	Infection and immunity 1999-09, Vol.67 (9), p.4931-4934
Hauptverfasser:	BISHAI, W. R, DANNENBERG, A. M, PARRISH, N, RUIZ, R, PING CHEN, ZOOK, B. C, JOHNSON, W, BOLES, J. W, PITT, M. L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial diseases Biological and medical sciences Experimental bacterial diseases and models Host Response and Inflammation Infectious diseases Medical sciences Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Rabbits Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Virulence
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Zusammenfassung:	The virulence of the CDC1551 strain of Mycobacterium tuberculosis was compared to that of H37Rv in a rabbit inhalation model. While rabbits that inhaled the two strains produced equal numbers of grossly visible primary tubercles, CDC1551 tubercles were smaller and contained fewer bacilli than H37Rv tubercles. These findings suggest that a miniepidemic near the Kentucky-Tennessee border caused by CDC1551 was due not to increased virulence but to increased transmissibility.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.67.9.4931-4934.1999