Density and Fat Fraction of the Psoas, Paraspinal, and Oblique Muscle Groups Are Associated With Lumbar Vertebral Bone Mineral Density in a Multi‐Ethnic Community‐Living Population: The Multi‐Ethnic Study of Atherosclerosis
ABSTRACT Low vertebral bone mass is a major risk factor for vertebral compression fractures. Although sarcopenia has been shown to be associated with low bone mineral density (BMD), it is not known whether trunk musculature is directly associated with lumbar BMD, and whether exercise modifies this a...
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| Veröffentlicht in: | Journal of bone and mineral research 2022-08, Vol.37 (8), p.1537-1544 |
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| creator | Gurusamy, Pradyumna Larsen, Britta A. Allen, Richard T. Ward, Samuel R. Allison, Matthew A. Hughes‐Austin, Jan M. |
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Low vertebral bone mass is a major risk factor for vertebral compression fractures. Although sarcopenia has been shown to be associated with low bone mineral density (BMD), it is not known whether trunk musculature is directly associated with lumbar BMD, and whether exercise modifies this association. Using data from the Multi‐Ethnic Study of Atherosclerosis (MESA), we sought to determine the association of muscle density and fat fraction of the psoas, paraspinal, and oblique muscle groups with L3 lumbar volumetric BMD, and whether these associations were modified by exercise. We obtained L3 vBMD measurements, and fat and muscle measurements (in Hounsfield units [HU]) from abdominal computed tomography (CT) scans spanning the L2–L4 intervertebral disc spaces. Muscle density was defined as the mean HU value for a muscle group area. Fat fraction was calculated as the mean HU value for the muscle group fat area/total muscle group area (cm2). Exercise data were self‐reported (MET‐minute/week). We utilized multivariable linear regression to evaluate these associations, stratified by gender, and adjusting for demographics, body mass index (BMI), smoking status, impaired fasting glucose, and corticosteroid and anti‐resorptive medication use. Among 1923 MESA participants, mean ± standard deviation (SD) age was 62 ± 10 years, 49% were female, 40% white, 21% black, 26% Hispanic/Latino, and 13% Chinese. In fully adjusted analysis, for every 1‐SD higher psoas fat fraction, there was a 3.19‐SD lower L3 vBMD in men and 4.3‐SD lower L3 vBMD in women (p |
| doi_str_mv | 10.1002/jbmr.4634 |
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Low vertebral bone mass is a major risk factor for vertebral compression fractures. Although sarcopenia has been shown to be associated with low bone mineral density (BMD), it is not known whether trunk musculature is directly associated with lumbar BMD, and whether exercise modifies this association. Using data from the Multi‐Ethnic Study of Atherosclerosis (MESA), we sought to determine the association of muscle density and fat fraction of the psoas, paraspinal, and oblique muscle groups with L3 lumbar volumetric BMD, and whether these associations were modified by exercise. We obtained L3 vBMD measurements, and fat and muscle measurements (in Hounsfield units [HU]) from abdominal computed tomography (CT) scans spanning the L2–L4 intervertebral disc spaces. Muscle density was defined as the mean HU value for a muscle group area. Fat fraction was calculated as the mean HU value for the muscle group fat area/total muscle group area (cm2). Exercise data were self‐reported (MET‐minute/week). We utilized multivariable linear regression to evaluate these associations, stratified by gender, and adjusting for demographics, body mass index (BMI), smoking status, impaired fasting glucose, and corticosteroid and anti‐resorptive medication use. Among 1923 MESA participants, mean ± standard deviation (SD) age was 62 ± 10 years, 49% were female, 40% white, 21% black, 26% Hispanic/Latino, and 13% Chinese. In fully adjusted analysis, for every 1‐SD higher psoas fat fraction, there was a 3.19‐SD lower L3 vBMD in men and 4.3‐SD lower L3 vBMD in women (p < 0.001). For every 1‐SD higher psoas density, there was a 0.2‐SD higher L3 vBMD (p < 0.001) in men and 0.19‐SD higher L3 vBMD (p < 0.001) in women. Findings were similar for paraspinal and oblique muscles. Intentional exercise did not modify these associations. In men and women, trunk muscle density was positively associated with higher lumbar BMD, suggesting a local association. Future studies are warranted to determine the temporality of this association. © 2022 American Society for Bone and Mineral Research (ASBMR).</description><identifier>ISSN: 0884-0431</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1002/jbmr.4634</identifier><identifier>PMID: 35690917</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aged ; Arteriosclerosis ; Atherosclerosis ; Body mass index ; Bone density ; Bone Density - physiology ; Bone Diseases, Metabolic ; Bone mass ; BONE MINERAL DENSITY ; Compression ; Computed tomography ; EPIDEMIOLOGY ; Female ; Fractures ; Fractures, Compression ; Humans ; Intervertebral discs ; LUMBAR SPINE ; Lumbar Vertebrae - diagnostic imaging ; Male ; Middle Aged ; MUSCLE DENSITY ; MUSCLE FAT FRACTION ; Muscles ; Population studies ; Risk factors ; Sarcopenia ; Spinal Fractures ; Vertebrae ; Women</subject><ispartof>Journal of bone and mineral research, 2022-08, Vol.37 (8), p.1537-1544</ispartof><rights>2022 American Society for Bone and Mineral Research (ASBMR).</rights><rights>2022 American Society for Bone and Mineral Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4434-a689c4c78f21f4afff3af3e6617db8e5cc8da7d1a0158105119d4f9e253dac3b3</citedby><cites>FETCH-LOGICAL-c4434-a689c4c78f21f4afff3af3e6617db8e5cc8da7d1a0158105119d4f9e253dac3b3</cites><orcidid>0000-0002-7255-274X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbmr.4634$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbmr.4634$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35690917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gurusamy, Pradyumna</creatorcontrib><creatorcontrib>Larsen, Britta A.</creatorcontrib><creatorcontrib>Allen, Richard T.</creatorcontrib><creatorcontrib>Ward, Samuel R.</creatorcontrib><creatorcontrib>Allison, Matthew A.</creatorcontrib><creatorcontrib>Hughes‐Austin, Jan M.</creatorcontrib><title>Density and Fat Fraction of the Psoas, Paraspinal, and Oblique Muscle Groups Are Associated With Lumbar Vertebral Bone Mineral Density in a Multi‐Ethnic Community‐Living Population: The Multi‐Ethnic Study of Atherosclerosis</title><title>Journal of bone and mineral research</title><addtitle>J Bone Miner Res</addtitle><description>ABSTRACT
Low vertebral bone mass is a major risk factor for vertebral compression fractures. Although sarcopenia has been shown to be associated with low bone mineral density (BMD), it is not known whether trunk musculature is directly associated with lumbar BMD, and whether exercise modifies this association. Using data from the Multi‐Ethnic Study of Atherosclerosis (MESA), we sought to determine the association of muscle density and fat fraction of the psoas, paraspinal, and oblique muscle groups with L3 lumbar volumetric BMD, and whether these associations were modified by exercise. We obtained L3 vBMD measurements, and fat and muscle measurements (in Hounsfield units [HU]) from abdominal computed tomography (CT) scans spanning the L2–L4 intervertebral disc spaces. Muscle density was defined as the mean HU value for a muscle group area. Fat fraction was calculated as the mean HU value for the muscle group fat area/total muscle group area (cm2). Exercise data were self‐reported (MET‐minute/week). We utilized multivariable linear regression to evaluate these associations, stratified by gender, and adjusting for demographics, body mass index (BMI), smoking status, impaired fasting glucose, and corticosteroid and anti‐resorptive medication use. Among 1923 MESA participants, mean ± standard deviation (SD) age was 62 ± 10 years, 49% were female, 40% white, 21% black, 26% Hispanic/Latino, and 13% Chinese. In fully adjusted analysis, for every 1‐SD higher psoas fat fraction, there was a 3.19‐SD lower L3 vBMD in men and 4.3‐SD lower L3 vBMD in women (p < 0.001). For every 1‐SD higher psoas density, there was a 0.2‐SD higher L3 vBMD (p < 0.001) in men and 0.19‐SD higher L3 vBMD (p < 0.001) in women. Findings were similar for paraspinal and oblique muscles. Intentional exercise did not modify these associations. In men and women, trunk muscle density was positively associated with higher lumbar BMD, suggesting a local association. Future studies are warranted to determine the temporality of this association. © 2022 American Society for Bone and Mineral Research (ASBMR).</description><subject>Aged</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Body mass index</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Bone Diseases, Metabolic</subject><subject>Bone mass</subject><subject>BONE MINERAL DENSITY</subject><subject>Compression</subject><subject>Computed tomography</subject><subject>EPIDEMIOLOGY</subject><subject>Female</subject><subject>Fractures</subject><subject>Fractures, Compression</subject><subject>Humans</subject><subject>Intervertebral discs</subject><subject>LUMBAR SPINE</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MUSCLE DENSITY</subject><subject>MUSCLE FAT FRACTION</subject><subject>Muscles</subject><subject>Population studies</subject><subject>Risk factors</subject><subject>Sarcopenia</subject><subject>Spinal Fractures</subject><subject>Vertebrae</subject><subject>Women</subject><issn>0884-0431</issn><issn>1523-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ksFu1DAQhiMEotvCgRdAlriA1LR24jhJD0jbbbeAtuoKChytieN0vUrsYDtFe-MReEYk3gOn21ZQiYste775_XtmougFwQcE4-RwXXX2gLKUPoomJEvSmLKCPI4muChojGlKdqJd59YYY5Yx9jTaSTNW4pLkk-j3idRO-Q0CXaM5eDS3ILwyGpkG-ZVES2fA7aMlWHC90tDu36AXVau-DRKdD060Ep1ZM_QOTa1EU-eMUOBljb4qv0KLoavAoi_SellZaNGx0SFPaTke7p5XGkEQa7369ePnqV9pJdDMdN2gQzRcLdS10ldoafqhhdHfEbpcyYcZn_xQb0bn02DdmtFaWJV7Fj1poHXy-e2-F32en17O3sWLi7P3s-kiFpSmNAZWlIKKvGgS0lBomiaFJpWMkbyuCpkJUdSQ1wQwyQqCM0LKmjalTLK0BpFW6V70dqvbD1UnayG1D5_kvVUd2A03oPi_Ea1W_Mpc85IVSZlnQeD1rYA1obzO8045IdsWtDSD4wnLM4YTikf01QN0bQYbGjRSZVniJHQ5UG-2lAiFcFY292YI5uPw8HF4-Dg8gX35t_t78m5aAnC4Bb6rVm7-r8Q_HJ9_vJH8A_WS1y4</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Gurusamy, Pradyumna</creator><creator>Larsen, Britta A.</creator><creator>Allen, Richard T.</creator><creator>Ward, Samuel R.</creator><creator>Allison, Matthew A.</creator><creator>Hughes‐Austin, Jan M.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7255-274X</orcidid></search><sort><creationdate>202208</creationdate><title>Density and Fat Fraction of the Psoas, Paraspinal, and Oblique Muscle Groups Are Associated With Lumbar Vertebral Bone Mineral Density in a Multi‐Ethnic Community‐Living Population: The Multi‐Ethnic Study of Atherosclerosis</title><author>Gurusamy, Pradyumna ; Larsen, Britta A. ; Allen, Richard T. ; Ward, Samuel R. ; Allison, Matthew A. ; Hughes‐Austin, Jan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4434-a689c4c78f21f4afff3af3e6617db8e5cc8da7d1a0158105119d4f9e253dac3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Body mass index</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Bone Diseases, Metabolic</topic><topic>Bone mass</topic><topic>BONE MINERAL DENSITY</topic><topic>Compression</topic><topic>Computed tomography</topic><topic>EPIDEMIOLOGY</topic><topic>Female</topic><topic>Fractures</topic><topic>Fractures, Compression</topic><topic>Humans</topic><topic>Intervertebral discs</topic><topic>LUMBAR SPINE</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MUSCLE DENSITY</topic><topic>MUSCLE FAT FRACTION</topic><topic>Muscles</topic><topic>Population studies</topic><topic>Risk factors</topic><topic>Sarcopenia</topic><topic>Spinal Fractures</topic><topic>Vertebrae</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gurusamy, Pradyumna</creatorcontrib><creatorcontrib>Larsen, Britta A.</creatorcontrib><creatorcontrib>Allen, Richard T.</creatorcontrib><creatorcontrib>Ward, Samuel R.</creatorcontrib><creatorcontrib>Allison, Matthew A.</creatorcontrib><creatorcontrib>Hughes‐Austin, Jan M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of bone and mineral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gurusamy, Pradyumna</au><au>Larsen, Britta A.</au><au>Allen, Richard T.</au><au>Ward, Samuel R.</au><au>Allison, Matthew A.</au><au>Hughes‐Austin, Jan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Density and Fat Fraction of the Psoas, Paraspinal, and Oblique Muscle Groups Are Associated With Lumbar Vertebral Bone Mineral Density in a Multi‐Ethnic Community‐Living Population: The Multi‐Ethnic Study of Atherosclerosis</atitle><jtitle>Journal of bone and mineral research</jtitle><addtitle>J Bone Miner Res</addtitle><date>2022-08</date><risdate>2022</risdate><volume>37</volume><issue>8</issue><spage>1537</spage><epage>1544</epage><pages>1537-1544</pages><issn>0884-0431</issn><eissn>1523-4681</eissn><abstract>ABSTRACT
Low vertebral bone mass is a major risk factor for vertebral compression fractures. Although sarcopenia has been shown to be associated with low bone mineral density (BMD), it is not known whether trunk musculature is directly associated with lumbar BMD, and whether exercise modifies this association. Using data from the Multi‐Ethnic Study of Atherosclerosis (MESA), we sought to determine the association of muscle density and fat fraction of the psoas, paraspinal, and oblique muscle groups with L3 lumbar volumetric BMD, and whether these associations were modified by exercise. We obtained L3 vBMD measurements, and fat and muscle measurements (in Hounsfield units [HU]) from abdominal computed tomography (CT) scans spanning the L2–L4 intervertebral disc spaces. Muscle density was defined as the mean HU value for a muscle group area. Fat fraction was calculated as the mean HU value for the muscle group fat area/total muscle group area (cm2). Exercise data were self‐reported (MET‐minute/week). We utilized multivariable linear regression to evaluate these associations, stratified by gender, and adjusting for demographics, body mass index (BMI), smoking status, impaired fasting glucose, and corticosteroid and anti‐resorptive medication use. Among 1923 MESA participants, mean ± standard deviation (SD) age was 62 ± 10 years, 49% were female, 40% white, 21% black, 26% Hispanic/Latino, and 13% Chinese. In fully adjusted analysis, for every 1‐SD higher psoas fat fraction, there was a 3.19‐SD lower L3 vBMD in men and 4.3‐SD lower L3 vBMD in women (p < 0.001). For every 1‐SD higher psoas density, there was a 0.2‐SD higher L3 vBMD (p < 0.001) in men and 0.19‐SD higher L3 vBMD (p < 0.001) in women. Findings were similar for paraspinal and oblique muscles. Intentional exercise did not modify these associations. In men and women, trunk muscle density was positively associated with higher lumbar BMD, suggesting a local association. Future studies are warranted to determine the temporality of this association. © 2022 American Society for Bone and Mineral Research (ASBMR).</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>35690917</pmid><doi>10.1002/jbmr.4634</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7255-274X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Arteriosclerosis Atherosclerosis Body mass index Bone density Bone Density - physiology Bone Diseases, Metabolic Bone mass BONE MINERAL DENSITY Compression Computed tomography EPIDEMIOLOGY Female Fractures Fractures, Compression Humans Intervertebral discs LUMBAR SPINE Lumbar Vertebrae - diagnostic imaging Male Middle Aged MUSCLE DENSITY MUSCLE FAT FRACTION Muscles Population studies Risk factors Sarcopenia Spinal Fractures Vertebrae Women |
| title | Density and Fat Fraction of the Psoas, Paraspinal, and Oblique Muscle Groups Are Associated With Lumbar Vertebral Bone Mineral Density in a Multi‐Ethnic Community‐Living Population: The Multi‐Ethnic Study of Atherosclerosis |
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