Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

•A CRISPR/Cas9 screen targeting RNA binding proteins identifies RBM12 as a novel HbF regulator.•RBM12-mediated HbF repression is BCL11A-independent and reliant on its RRM1 domain. [Display omitted] The fetal-to-adult hemoglobin transition is clinically relevant because reactivation of fetal hemoglob...

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Veröffentlicht in:	Blood advances 2022-12, Vol.6 (23), p.5956-5968
Hauptverfasser:	Wakabayashi, Aoi, Kihiu, Maryanne, Sharma, Malini, Thrasher, A. Josephine, Saari, Megan S., Quesnel-Vallières, Mathieu, Abdulmalik, Osheiza, Peslak, Scott A., Khandros, Eugene, Keller, Cheryl A., Giardine, Belinda M., Barash, Yoseph, Hardison, Ross C., Shi, Junwei, Blobel, Gerd A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anemia, Sickle Cell - genetics Anemia, Sickle Cell - therapy beta-Thalassemia - genetics Cell Line, Tumor DNA-Binding Proteins - metabolism Fetal Hemoglobin - genetics Fetal Hemoglobin - metabolism Humans Regular RNA-Binding Proteins - genetics Transcription Factors - metabolism
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