Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations

Background and Objectives Prediction of antimicrobial target-site pharmacokinetics is of relevance to optimize treatment with antimicrobial agents. A physiologically based pharmacokinetic (PBPK) model framework was developed for prediction of pulmonary pharmacokinetics, including key pulmonary infec...

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Veröffentlicht in:	Clinical pharmacokinetics 2022-12, Vol.61 (12), p.1735-1748
Hauptverfasser:	Aulin, Linda B. S., Tandar, Sebastian T., van Zijp, Torben, van Ballegooie, Etienne, van der Graaf, Piet H., Saleh, Mohammed A. A., Välitalo, Pyry, van Hasselt, J. G. Coen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents Antibiotics Antimicrobial agents Blood vessels Humans Infections Internal Medicine Lung Medicine Medicine & Public Health Models, Biological Ordinary differential equations Original Original Research Article Permeability Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Physiology Plasma
Online-Zugang:	Volltext
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