Optimized thyroid transcription factor-1 core promoter-driven microRNA-7 expression effectively inhibits the growth of human non-small-cell lung cancer cells

Targeted gene therapy has become a promising approach for lung cancer treatment. In our previous work, we reported that the targeted expression of microRNA-7 (miR-7) operated by thyroid transcription factor-1 (TTF-1) promoter inhibited the growth of human lung cancer cells in vitro and in vivo; howe...

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Veröffentlicht in:	Journal of Zhejiang University. B. Science 2022-11, Vol.23 (11), p.915-930
Hauptverfasser:	Chen, Shipeng, Guan, Lian, Zhao, Xu, Yang, Jing, Chen, Longqing, Guo, Mengmeng, Zhao, Juanjuan, Chen, Chao, Zhou, Ya, Han, Yong, Xu, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 AKT protein Animals Binding sites Biomedical and Life Sciences Biomedicine Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - therapy Electrophoretic mobility Gene deletion Gene therapy Heart Histology Humans Kinases Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - therapy Metastases Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA NADH dehydrogenase NADH dehydrogenase (ubiquinone) Nicotinamide adenine dinucleotide Non-small cell lung carcinoma Nuclear Proteins - metabolism Proteins Research Article Ribonucleic acid RNA Small cell lung carcinoma Thyroid Thyroid gland Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Nuclear Factor 1 - genetics Transcription factors Transcription Factors - metabolism Tumor cells Ubiquinone Xenografts Xenotransplantation
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