3’UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension

Pulmonary hypertension (PH) comprises a diverse group of disorders that share a common pathway of pulmonary vascular remodeling leading to right ventricular failure. Development of anti-remodeling strategies is an emerging frontier in PH therapeutics that requires a greater understanding of the inte...

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Veröffentlicht in:	Matrix biology 2022-08, Vol.111, p.53-75
Hauptverfasser:	Tseng, Victor, Collum, Scott D., Allawzi, Ayed, Crotty, Kathryn, Yeligar, Samantha, Trammell, Aaron, Ryan Smith, M., Kang, Bum-Yong, Sutliff, Roy L., Ingram, Jennifer L., Jyothula, Soma S.S.K., Thandavarayan, Rajarajan A., Huang, Howard J., Nozik, Eva S., Wagner, Eric J., Michael Hart, C., Karmouty-Quintana, Harry
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 3' Untranslated Regions - genetics Animals Apoptosis Bioenergetics Cell migration Cell Proliferation Energy Metabolism - genetics extracellular matrix Gene deletion Glycolysis Heart Humans Hyaluronan Hyaluronan Synthases - genetics Hyaluronan Synthases - metabolism Hyaluronic acid Hyaluronic Acid - biosynthesis Hypertension Hypertension, Pulmonary - enzymology hypoxia metabolism Mice Mice, Transgenic Mitochondria Muscle contraction Myocytes, Smooth Muscle - enzymology Phenotypes Polyadenylation Pulmonary arteries Pulmonary artery Pulmonary hypertension Right ventricular failure RNA processing deficiency Smooth muscle smooth muscle cell Transgenic mice Vascular biology Ventricle
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