von Willebrand factor unfolding mediates platelet deposition in a model of high-shear thrombosis

Thrombosis under high-shear conditions is mediated by the mechanosensitive blood glycoprotein von Willebrand factor (vWF). vWF unfolds in response to strong flow gradients and facilitates rapid recruitment of platelets in flowing blood. While the thrombogenic effect of vWF is well recognized, its co...

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Veröffentlicht in:	Biophysical journal 2022-11, Vol.121 (21), p.4033-4047
Hauptverfasser:	Zhussupbekov, Mansur, Méndez Rojano, Rodrigo, Wu, Wei-Tao, Antaki, James F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - physiology Hemostatics Humans Protein Unfolding Thrombosis von Willebrand Diseases - diagnosis von Willebrand Factor
Online-Zugang:	Volltext
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