Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin

Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular cond...

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Veröffentlicht in:	The Journal of cell biology 2022-12, Vol.221 (12), p.1
Hauptverfasser:	Babcock, Rachel L, Pruitt, Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Axin Protein - genetics Axin Protein - metabolism Axin Signaling Complex beta Catenin - genetics beta Catenin - metabolism Biochemistry Cell Signaling Dishevelled protein Dishevelled Proteins - genetics Dishevelled Proteins - metabolism Humans Phase separation Spotlight Wnt Signaling Pathway β-Catenin
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