Targeting TSPO Reduces Inflammation and Apoptosis in an In Vitro Photoreceptor-Like Model of Retinal Degeneration

The 18 kDa translocator protein (TSPO) is predominantly located in the mitochondrial outer membrane, playing an important role in steroidogenesis, inflammation, survival, and cell proliferation. Its expression in the CNS, and mainly in glial cells, is upregulated in neuropathologies and brain injury...

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Veröffentlicht in:	ACS chemical neuroscience 2022-11, Vol.13 (22), p.3188-3197
Hauptverfasser:	Corsi, Francesca, Baglini, Emma, Barresi, Elisabetta, Salerno, Silvia, Cerri, Chiara, Martini, Claudia, Da Settimo Passetti, Federico, Taliani, Sabrina, Gargini, Claudia, Piano, Ilaria
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Carrier Proteins Humans Inflammation - metabolism Ligands Lipopolysaccharides - pharmacology Neurodegenerative Diseases Receptors, GABA - metabolism Retinal Degeneration - drug therapy Retinal Degeneration - pathology
Online-Zugang:	Volltext
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