Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis
Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for cannabis use disorder in schizophrenia; however, gaps in the literature remain as to the potential role of neurocognitive functioning in treatment response. We evaluated the moderating role of select cognitive functions...
Gespeichert in:
| Veröffentlicht in: | NPJ schizophrenia 2022-11, Vol.8 (1), p.99-99, Article 99 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 99 |
|---|---|
| container_issue | 1 |
| container_start_page | 99 |
| container_title | NPJ schizophrenia |
| container_volume | 8 |
| creator | Johnstone, Samantha Lowe, Darby J. E. Kozak-Bidzinski, Karolina Sanches, Marcos Castle, David J. Rabin, Jennifer S. Rabin, Rachel A. George, Tony P. |
| description | Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for cannabis use disorder in schizophrenia; however, gaps in the literature remain as to the potential role of neurocognitive functioning in treatment response. We evaluated the moderating role of select cognitive functions including baseline executive functioning, verbal memory, and sustained attention, and we explore the mediating role of changes in task performance on changes in cannabis use in both active and sham rTMS groups. Participants underwent high-frequency (20 Hz) rTMS applied to the bilateral dorsolateral prefrontal cortex 5x/week for 4 weeks. Weekly self-report of cannabis use and semi-quantitative urinary carboxy-tetrahydrocannabinol levels were recorded. A neurocognitive battery assessing verbal memory, visuospatial working memory, verbal working memory, sustained attention, delayed discounting, and complex planning was administered pre- and post-treatment. Better baseline performance on tasks assessing sustained attention, delayed discounting, and complex planning moderated the extent to which participants in the active group reduced cannabis use. There were no significant indirect pathways between treatment, changes in neuropsychological performance, and changes in cannabis use; however, active rTMS improved complex planning and sustained attention. These preliminary findings suggest that there is a moderating role of sustained attention, delayed discounting, and complex planning on the effects of rTMS on cannabis use. Further, mediation models suggest rTMS may exert direct effects on cannabis use independent of its effects on cognitive functioning in people with SCZ. Trial Registration: clinicaltrials.gov: NCT03189810. |
| doi_str_mv | 10.1038/s41537-022-00303-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9668838</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2736949693</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-bb8b314eb3242bac3353b5d59db11a6d9c54325e5fde8b1f86e58b1fdbd6b3a93</originalsourceid><addsrcrecordid>eNp9kctu1TAQhiMEElXpC7CyxKYsUnyJnZgFEqrKRSqwoKwt25mc4yqxgyepVN6ib4xPU3FbsPFY83_za0Z_VT1n9IxR0b3ChknR1pTzmlJBRc0fVUe8lU2ttBaP__g_rU4QrymlXHPeifaouvsMa04-7WJYwg2QKfWQ7RJSJGkgGWZYNmHJNqIvT7AjmewuFsETXMK0jht_mq8-fX1JYBjAL0hKx9sYrQtIVgQSIkG_Dz_SvM9QXF4TS-YMY5hCtPmW2GjHWwz4rHoy2BHh5KEeV9_eXVydf6gvv7z_eP72svaNZEvtXOcEa8AJ3nBnvRBSONlL3TvGrOq1l43gEuTQQ-fY0CmQh9q7XjlhtTiu3my-8-om6D3EcuJo5hymso5JNpi_lRj2ZpdujFaq60RXDE4fDHL6vgIuZgroYRxthLSi4a1oG6VadkBf_INepzWXg-8ppRuttCgU3yifE2KG4dcyjJpD0mZL2pSkzX3ShpchsQ1hgeMO8m_r_0z9BOv7sP0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2736949693</pqid></control><display><type>article</type><title>Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis</title><source>SpringerOpen</source><source>Nature_OA刊</source><source>PubMed Central(OpenAccess)</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central Open Access</source><creator>Johnstone, Samantha ; Lowe, Darby J. E. ; Kozak-Bidzinski, Karolina ; Sanches, Marcos ; Castle, David J. ; Rabin, Jennifer S. ; Rabin, Rachel A. ; George, Tony P.</creator><creatorcontrib>Johnstone, Samantha ; Lowe, Darby J. E. ; Kozak-Bidzinski, Karolina ; Sanches, Marcos ; Castle, David J. ; Rabin, Jennifer S. ; Rabin, Rachel A. ; George, Tony P.</creatorcontrib><description>Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for cannabis use disorder in schizophrenia; however, gaps in the literature remain as to the potential role of neurocognitive functioning in treatment response. We evaluated the moderating role of select cognitive functions including baseline executive functioning, verbal memory, and sustained attention, and we explore the mediating role of changes in task performance on changes in cannabis use in both active and sham rTMS groups. Participants underwent high-frequency (20 Hz) rTMS applied to the bilateral dorsolateral prefrontal cortex 5x/week for 4 weeks. Weekly self-report of cannabis use and semi-quantitative urinary carboxy-tetrahydrocannabinol levels were recorded. A neurocognitive battery assessing verbal memory, visuospatial working memory, verbal working memory, sustained attention, delayed discounting, and complex planning was administered pre- and post-treatment. Better baseline performance on tasks assessing sustained attention, delayed discounting, and complex planning moderated the extent to which participants in the active group reduced cannabis use. There were no significant indirect pathways between treatment, changes in neuropsychological performance, and changes in cannabis use; however, active rTMS improved complex planning and sustained attention. These preliminary findings suggest that there is a moderating role of sustained attention, delayed discounting, and complex planning on the effects of rTMS on cannabis use. Further, mediation models suggest rTMS may exert direct effects on cannabis use independent of its effects on cognitive functioning in people with SCZ. Trial Registration: clinicaltrials.gov: NCT03189810.</description><identifier>ISSN: 2754-6993</identifier><identifier>EISSN: 2754-6993</identifier><identifier>EISSN: 2334-265X</identifier><identifier>DOI: 10.1038/s41537-022-00303-2</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/477/2811 ; 692/699/476/1799 ; Cognitive Psychology ; Marijuana ; Medicine ; Medicine & Public Health ; Memory ; Neurology ; Neurosciences ; Psychiatry ; Schizophrenia ; Transcranial magnetic stimulation</subject><ispartof>NPJ schizophrenia, 2022-11, Vol.8 (1), p.99-99, Article 99</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-bb8b314eb3242bac3353b5d59db11a6d9c54325e5fde8b1f86e58b1fdbd6b3a93</citedby><cites>FETCH-LOGICAL-c451t-bb8b314eb3242bac3353b5d59db11a6d9c54325e5fde8b1f86e58b1fdbd6b3a93</cites><orcidid>0000-0002-5459-265X ; 0000-0001-9075-1761 ; 0000-0003-1645-9767</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668838/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668838/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids></links><search><creatorcontrib>Johnstone, Samantha</creatorcontrib><creatorcontrib>Lowe, Darby J. E.</creatorcontrib><creatorcontrib>Kozak-Bidzinski, Karolina</creatorcontrib><creatorcontrib>Sanches, Marcos</creatorcontrib><creatorcontrib>Castle, David J.</creatorcontrib><creatorcontrib>Rabin, Jennifer S.</creatorcontrib><creatorcontrib>Rabin, Rachel A.</creatorcontrib><creatorcontrib>George, Tony P.</creatorcontrib><title>Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis</title><title>NPJ schizophrenia</title><addtitle>Schizophr</addtitle><description>Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for cannabis use disorder in schizophrenia; however, gaps in the literature remain as to the potential role of neurocognitive functioning in treatment response. We evaluated the moderating role of select cognitive functions including baseline executive functioning, verbal memory, and sustained attention, and we explore the mediating role of changes in task performance on changes in cannabis use in both active and sham rTMS groups. Participants underwent high-frequency (20 Hz) rTMS applied to the bilateral dorsolateral prefrontal cortex 5x/week for 4 weeks. Weekly self-report of cannabis use and semi-quantitative urinary carboxy-tetrahydrocannabinol levels were recorded. A neurocognitive battery assessing verbal memory, visuospatial working memory, verbal working memory, sustained attention, delayed discounting, and complex planning was administered pre- and post-treatment. Better baseline performance on tasks assessing sustained attention, delayed discounting, and complex planning moderated the extent to which participants in the active group reduced cannabis use. There were no significant indirect pathways between treatment, changes in neuropsychological performance, and changes in cannabis use; however, active rTMS improved complex planning and sustained attention. These preliminary findings suggest that there is a moderating role of sustained attention, delayed discounting, and complex planning on the effects of rTMS on cannabis use. Further, mediation models suggest rTMS may exert direct effects on cannabis use independent of its effects on cognitive functioning in people with SCZ. Trial Registration: clinicaltrials.gov: NCT03189810.</description><subject>631/477/2811</subject><subject>692/699/476/1799</subject><subject>Cognitive Psychology</subject><subject>Marijuana</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Transcranial magnetic stimulation</subject><issn>2754-6993</issn><issn>2754-6993</issn><issn>2334-265X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctu1TAQhiMEElXpC7CyxKYsUnyJnZgFEqrKRSqwoKwt25mc4yqxgyepVN6ib4xPU3FbsPFY83_za0Z_VT1n9IxR0b3ChknR1pTzmlJBRc0fVUe8lU2ttBaP__g_rU4QrymlXHPeifaouvsMa04-7WJYwg2QKfWQ7RJSJGkgGWZYNmHJNqIvT7AjmewuFsETXMK0jht_mq8-fX1JYBjAL0hKx9sYrQtIVgQSIkG_Dz_SvM9QXF4TS-YMY5hCtPmW2GjHWwz4rHoy2BHh5KEeV9_eXVydf6gvv7z_eP72svaNZEvtXOcEa8AJ3nBnvRBSONlL3TvGrOq1l43gEuTQQ-fY0CmQh9q7XjlhtTiu3my-8-om6D3EcuJo5hymso5JNpi_lRj2ZpdujFaq60RXDE4fDHL6vgIuZgroYRxthLSi4a1oG6VadkBf_INepzWXg-8ppRuttCgU3yifE2KG4dcyjJpD0mZL2pSkzX3ShpchsQ1hgeMO8m_r_0z9BOv7sP0</recordid><startdate>20221117</startdate><enddate>20221117</enddate><creator>Johnstone, Samantha</creator><creator>Lowe, Darby J. E.</creator><creator>Kozak-Bidzinski, Karolina</creator><creator>Sanches, Marcos</creator><creator>Castle, David J.</creator><creator>Rabin, Jennifer S.</creator><creator>Rabin, Rachel A.</creator><creator>George, Tony P.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5459-265X</orcidid><orcidid>https://orcid.org/0000-0001-9075-1761</orcidid><orcidid>https://orcid.org/0000-0003-1645-9767</orcidid></search><sort><creationdate>20221117</creationdate><title>Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis</title><author>Johnstone, Samantha ; Lowe, Darby J. E. ; Kozak-Bidzinski, Karolina ; Sanches, Marcos ; Castle, David J. ; Rabin, Jennifer S. ; Rabin, Rachel A. ; George, Tony P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-bb8b314eb3242bac3353b5d59db11a6d9c54325e5fde8b1f86e58b1fdbd6b3a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>631/477/2811</topic><topic>692/699/476/1799</topic><topic>Cognitive Psychology</topic><topic>Marijuana</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Memory</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Transcranial magnetic stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnstone, Samantha</creatorcontrib><creatorcontrib>Lowe, Darby J. E.</creatorcontrib><creatorcontrib>Kozak-Bidzinski, Karolina</creatorcontrib><creatorcontrib>Sanches, Marcos</creatorcontrib><creatorcontrib>Castle, David J.</creatorcontrib><creatorcontrib>Rabin, Jennifer S.</creatorcontrib><creatorcontrib>Rabin, Rachel A.</creatorcontrib><creatorcontrib>George, Tony P.</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NPJ schizophrenia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnstone, Samantha</au><au>Lowe, Darby J. E.</au><au>Kozak-Bidzinski, Karolina</au><au>Sanches, Marcos</au><au>Castle, David J.</au><au>Rabin, Jennifer S.</au><au>Rabin, Rachel A.</au><au>George, Tony P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis</atitle><jtitle>NPJ schizophrenia</jtitle><stitle>Schizophr</stitle><date>2022-11-17</date><risdate>2022</risdate><volume>8</volume><issue>1</issue><spage>99</spage><epage>99</epage><pages>99-99</pages><artnum>99</artnum><issn>2754-6993</issn><eissn>2754-6993</eissn><eissn>2334-265X</eissn><abstract>Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for cannabis use disorder in schizophrenia; however, gaps in the literature remain as to the potential role of neurocognitive functioning in treatment response. We evaluated the moderating role of select cognitive functions including baseline executive functioning, verbal memory, and sustained attention, and we explore the mediating role of changes in task performance on changes in cannabis use in both active and sham rTMS groups. Participants underwent high-frequency (20 Hz) rTMS applied to the bilateral dorsolateral prefrontal cortex 5x/week for 4 weeks. Weekly self-report of cannabis use and semi-quantitative urinary carboxy-tetrahydrocannabinol levels were recorded. A neurocognitive battery assessing verbal memory, visuospatial working memory, verbal working memory, sustained attention, delayed discounting, and complex planning was administered pre- and post-treatment. Better baseline performance on tasks assessing sustained attention, delayed discounting, and complex planning moderated the extent to which participants in the active group reduced cannabis use. There were no significant indirect pathways between treatment, changes in neuropsychological performance, and changes in cannabis use; however, active rTMS improved complex planning and sustained attention. These preliminary findings suggest that there is a moderating role of sustained attention, delayed discounting, and complex planning on the effects of rTMS on cannabis use. Further, mediation models suggest rTMS may exert direct effects on cannabis use independent of its effects on cognitive functioning in people with SCZ. Trial Registration: clinicaltrials.gov: NCT03189810.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/s41537-022-00303-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5459-265X</orcidid><orcidid>https://orcid.org/0000-0001-9075-1761</orcidid><orcidid>https://orcid.org/0000-0003-1645-9767</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2754-6993 |
| ispartof | NPJ schizophrenia, 2022-11, Vol.8 (1), p.99-99, Article 99 |
| issn | 2754-6993 2754-6993 2334-265X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9668838 |
| source | SpringerOpen; Nature_OA刊; PubMed Central(OpenAccess); DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central Open Access |
| subjects | 631/477/2811 692/699/476/1799 Cognitive Psychology Marijuana Medicine Medicine & Public Health Memory Neurology Neurosciences Psychiatry Schizophrenia Transcranial magnetic stimulation |
| title | Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A49%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurocognitive%20moderation%20of%20repetitive%20transcranial%20magnetic%20stimulation%20(rTMS)%20effects%20on%20cannabis%20use%20in%20schizophrenia:%20a%20preliminary%20analysis&rft.jtitle=NPJ%20schizophrenia&rft.au=Johnstone,%20Samantha&rft.date=2022-11-17&rft.volume=8&rft.issue=1&rft.spage=99&rft.epage=99&rft.pages=99-99&rft.artnum=99&rft.issn=2754-6993&rft.eissn=2754-6993&rft_id=info:doi/10.1038/s41537-022-00303-2&rft_dat=%3Cproquest_pubme%3E2736949693%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2736949693&rft_id=info:pmid/&rfr_iscdi=true |