Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities
Pall. var. (Fisch.) Koidz ( ) is an herbaceous perennial widely distributed in China, India, and South Korea. has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known oligostilbenes (compounds 2, 3 and 4) from t...
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| Veröffentlicht in: | RSC advances 2022-11, Vol.12 (51), p.32912-32922 |
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| creator | Tie, Fang-Fang Fu, Yang-Yang Hu, Na Chen, Zhi Wang, Hong-Lun |
| description | Pall. var.
(Fisch.) Koidz (
) is an herbaceous perennial widely distributed in China, India, and South Korea.
has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known oligostilbenes (compounds 2, 3 and 4) from the seeds of
The structures of these compounds were elucidated by HRESIMS, NMR, and chemical analyses. The network-based pharmacologic analysis platform was used to predict the target proteins related to inflammation of isolated compounds. Furthermore, the isolated compounds were tested for their anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. In this network, 138 candidate targets of compounds related to its therapeutic effect on inflammation were identified. In addition, compounds 1, 2, 3 and 4 significantly decreased NO content and the IL-6 levels as well as the expression of COX-2 in LPS-stimulated RAW 264.7 cells. |
| doi_str_mv | 10.1039/d2ra05176a |
| format | Article |
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(Fisch.) Koidz (
) is an herbaceous perennial widely distributed in China, India, and South Korea.
has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known oligostilbenes (compounds 2, 3 and 4) from the seeds of
The structures of these compounds were elucidated by HRESIMS, NMR, and chemical analyses. The network-based pharmacologic analysis platform was used to predict the target proteins related to inflammation of isolated compounds. Furthermore, the isolated compounds were tested for their anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. In this network, 138 candidate targets of compounds related to its therapeutic effect on inflammation were identified. In addition, compounds 1, 2, 3 and 4 significantly decreased NO content and the IL-6 levels as well as the expression of COX-2 in LPS-stimulated RAW 264.7 cells.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d2ra05176a</identifier><identifier>PMID: 36425180</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Chemistry ; NMR ; Nuclear magnetic resonance ; Traditional Chinese medicine</subject><ispartof>RSC advances, 2022-11, Vol.12 (51), p.32912-32922</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2022</rights><rights>This journal is © The Royal Society of Chemistry 2022 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-a8ddd3890689139ffba7066c5bd3fb07f744a21cc3117e3a7a1610d76f4b59dd3</citedby><cites>FETCH-LOGICAL-c370t-a8ddd3890689139ffba7066c5bd3fb07f744a21cc3117e3a7a1610d76f4b59dd3</cites><orcidid>0000-0002-9882-9604</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667474/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667474/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36425180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tie, Fang-Fang</creatorcontrib><creatorcontrib>Fu, Yang-Yang</creatorcontrib><creatorcontrib>Hu, Na</creatorcontrib><creatorcontrib>Chen, Zhi</creatorcontrib><creatorcontrib>Wang, Hong-Lun</creatorcontrib><title>Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Pall. var.
(Fisch.) Koidz (
) is an herbaceous perennial widely distributed in China, India, and South Korea.
has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known oligostilbenes (compounds 2, 3 and 4) from the seeds of
The structures of these compounds were elucidated by HRESIMS, NMR, and chemical analyses. The network-based pharmacologic analysis platform was used to predict the target proteins related to inflammation of isolated compounds. Furthermore, the isolated compounds were tested for their anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. In this network, 138 candidate targets of compounds related to its therapeutic effect on inflammation were identified. In addition, compounds 1, 2, 3 and 4 significantly decreased NO content and the IL-6 levels as well as the expression of COX-2 in LPS-stimulated RAW 264.7 cells.</description><subject>Chemistry</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Traditional Chinese medicine</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkV9rVDEQxS9isaX2xQ8gAV-qcLfJTW6yeRGWanVpQRF9DnPzp5uSm9Qku1I_vamtpXZeZmB-czjD6bpXBC8IpvLEDBnwSASHZ93BgBnvB8zl80fzfndUyhVuxUcycPKi26ecDSNZ4oPu17qkANWniJJDKfjLVKoPk422IJfTjNbZFxRAVwvoK4SwQDvIC6Q3PtpY2u74zBe9WbxF58mb3wiiQXVjfW5T9b2PLsA8Q035BjUVv_PV2_Ky23MQij2674fdj7OP308_9xdfPq1PVxe9pgLXHpbGGLqUmC8lodK5CQTmXI-ToW7CwgnGYCBaU0KEpSCAcIKN4I5No2ynh937O93r7TRbo22sGYK6zn6GfKMSePX_JvqNukw7JTkXTLAmcHwvkNPPrS1Vze1dGwJEm7ZFDYLhEY-U3aJvnqBXaZtje69RVLKBCIkb9e6O0jmVkq17MEOwuo1UfRi-rf5Gumrw68f2H9B_AdI_8ZudHQ</recordid><startdate>20221115</startdate><enddate>20221115</enddate><creator>Tie, Fang-Fang</creator><creator>Fu, Yang-Yang</creator><creator>Hu, Na</creator><creator>Chen, Zhi</creator><creator>Wang, Hong-Lun</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9882-9604</orcidid></search><sort><creationdate>20221115</creationdate><title>Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities</title><author>Tie, Fang-Fang ; Fu, Yang-Yang ; Hu, Na ; Chen, Zhi ; Wang, Hong-Lun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-a8ddd3890689139ffba7066c5bd3fb07f744a21cc3117e3a7a1610d76f4b59dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chemistry</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tie, Fang-Fang</creatorcontrib><creatorcontrib>Fu, Yang-Yang</creatorcontrib><creatorcontrib>Hu, Na</creatorcontrib><creatorcontrib>Chen, Zhi</creatorcontrib><creatorcontrib>Wang, Hong-Lun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tie, Fang-Fang</au><au>Fu, Yang-Yang</au><au>Hu, Na</au><au>Chen, Zhi</au><au>Wang, Hong-Lun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2022-11-15</date><risdate>2022</risdate><volume>12</volume><issue>51</issue><spage>32912</spage><epage>32922</epage><pages>32912-32922</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Pall. var.
(Fisch.) Koidz (
) is an herbaceous perennial widely distributed in China, India, and South Korea.
has been extensively used in traditional Chinese medicine. The present study isolated a new oligostilbene (compound 1), together with three known oligostilbenes (compounds 2, 3 and 4) from the seeds of
The structures of these compounds were elucidated by HRESIMS, NMR, and chemical analyses. The network-based pharmacologic analysis platform was used to predict the target proteins related to inflammation of isolated compounds. Furthermore, the isolated compounds were tested for their anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. In this network, 138 candidate targets of compounds related to its therapeutic effect on inflammation were identified. In addition, compounds 1, 2, 3 and 4 significantly decreased NO content and the IL-6 levels as well as the expression of COX-2 in LPS-stimulated RAW 264.7 cells.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36425180</pmid><doi>10.1039/d2ra05176a</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9882-9604</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Chemistry NMR Nuclear magnetic resonance Traditional Chinese medicine |
| title | Isolation of oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz and their anti-inflammatory activities |
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