Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer
Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been recognized as an organism that supp...
Gespeichert in:
| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2022-11, Vol.2022, p.1-9 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9 |
|---|---|
| container_issue | |
| container_start_page | 1 |
| container_title | Evidence-based complementary and alternative medicine |
| container_volume | 2022 |
| creator | Shin, Min-Ji Chae, Hae-Jung Lee, Ji Won Koo, Man Hyung Kim, Hyun-Jin Seo, Jong Bae yanIllia, Shagin Park, Sang Hee Lo, Han En Kim, Sung-Hak Youn, Ui Joung Jeon, Young-Jun Suh, Sung-Suk |
| description | Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been recognized as an organism that suppresses tumors and inflammation; however, the molecular mechanisms induced by a triterpenoid in Ganoderma lucidum, Lucidumol A, have not yet been fully explored in CRC and inflammatory responses. To this end, we extracted Lucidumol A from Ganoderma lucidum and analyzed its anticancer effect and anti-inflammatory potential in CRC cell lines and RAW264.7 macrophage-derived cell lines, respectively. A series of in vitro experiments including cell survival, wound healing, and migration assays were performed to determine the role of Lucidumol A in the CRC cell line. We also analyzed inflammatory responses using qRT-PCR, Western Blot, and ELISA in RAW 264.7 macrophaged-derived cell lines exposed to various concentrations of Lucidumol A. Lucidumol A efficiently suppressed the metastatic potential of CRC at very low concentrations. Furthermore, significant anti-inflammatory activities were observed in Lucidumol A-treated RAW264.7 cells through modulation of inflammation-associated marker genes and cytokines. In conclusion, Lucidumol A plays an important role in Ganoderma lucidum-dependent tumor suppression and anti-inflammation, suggesting different strategies to treat CRC patients, and other diseases evoked by proinflammatory cytokines, despite the need to explore further its mechanism of action. |
| doi_str_mv | 10.1155/2022/7404493 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9666013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2738193256</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-e909c231498d45921443fec0b5b9892949da0a21b71a5e0114ea5af5f47786173</originalsourceid><addsrcrecordid>eNp9kcFq3DAQhk1oIWnSWx9A0Esgu40kS5Z1CSzONg0sNIQWehNjWeoqyNJGspPuI_St6-0ugfTQ0wzMN__Mz18UHwj-RAjnlxRTeikYZkyWR8UJEYzMGa3rNy-9-HFcvMv5AWMqhRAnxe_VqF039tGjxQzdjclZZzp07ZLRg98im2KPbiDEzqQekN_TM7T8tXatGzJahMFpCNoktLR2WkIQOtQY70cPCd0G66HvYYhpi-5N3sSQDXIBNdHH3Q3wqPm7fla8teCzeX-op8X3z8tvzZf56uvNbbNYzXVZ02FuJJaaloTJumNcUsJYOZ3FLW9lLalksgMMlLSCADeYEGaAg-WWCVFXRJSnxdVedzO2vem0CUMCrzbJ9ZC2KoJTryfBrdXP-KRkVVWYlJPA-UEgxcfR5EH1LuvJMAQTx6yoKGsiS8qrCf34D_oQxxQmeztKSI4p5hM121M6xZyTsS_PEKx2wapdsOoQ7IRf7PG1Cx08u__TfwD5RaPf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2737950205</pqid></control><display><type>article</type><title>Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Shin, Min-Ji ; Chae, Hae-Jung ; Lee, Ji Won ; Koo, Man Hyung ; Kim, Hyun-Jin ; Seo, Jong Bae ; yanIllia, Shagin ; Park, Sang Hee ; Lo, Han En ; Kim, Sung-Hak ; Youn, Ui Joung ; Jeon, Young-Jun ; Suh, Sung-Suk</creator><contributor>Cohen, Guy ; Guy Cohen</contributor><creatorcontrib>Shin, Min-Ji ; Chae, Hae-Jung ; Lee, Ji Won ; Koo, Man Hyung ; Kim, Hyun-Jin ; Seo, Jong Bae ; yanIllia, Shagin ; Park, Sang Hee ; Lo, Han En ; Kim, Sung-Hak ; Youn, Ui Joung ; Jeon, Young-Jun ; Suh, Sung-Suk ; Cohen, Guy ; Guy Cohen</creatorcontrib><description>Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been recognized as an organism that suppresses tumors and inflammation; however, the molecular mechanisms induced by a triterpenoid in Ganoderma lucidum, Lucidumol A, have not yet been fully explored in CRC and inflammatory responses. To this end, we extracted Lucidumol A from Ganoderma lucidum and analyzed its anticancer effect and anti-inflammatory potential in CRC cell lines and RAW264.7 macrophage-derived cell lines, respectively. A series of in vitro experiments including cell survival, wound healing, and migration assays were performed to determine the role of Lucidumol A in the CRC cell line. We also analyzed inflammatory responses using qRT-PCR, Western Blot, and ELISA in RAW 264.7 macrophaged-derived cell lines exposed to various concentrations of Lucidumol A. Lucidumol A efficiently suppressed the metastatic potential of CRC at very low concentrations. Furthermore, significant anti-inflammatory activities were observed in Lucidumol A-treated RAW264.7 cells through modulation of inflammation-associated marker genes and cytokines. In conclusion, Lucidumol A plays an important role in Ganoderma lucidum-dependent tumor suppression and anti-inflammation, suggesting different strategies to treat CRC patients, and other diseases evoked by proinflammatory cytokines, despite the need to explore further its mechanism of action.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/7404493</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Antifungal agents ; Cell culture ; Cell survival ; Chemotherapy ; Colorectal cancer ; Colorectal carcinoma ; Cytokines ; Cytotoxicity ; Enzyme-linked immunosorbent assay ; Flow cytometry ; Ganoderma lucidum ; Immunotherapy ; Inflammation ; Kinases ; Leukocyte migration ; Macrophages ; Manufacturers ; Metastases ; Molecular modelling ; Morphology ; Mutation ; Proteins ; Solvents ; Statistical analysis ; Tumor suppression ; Tumors ; Wound healing</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-11, Vol.2022, p.1-9</ispartof><rights>Copyright © 2022 Min-Ji Shin et al.</rights><rights>Copyright © 2022 Min-Ji Shin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Min-Ji Shin et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c382t-e909c231498d45921443fec0b5b9892949da0a21b71a5e0114ea5af5f47786173</cites><orcidid>0000-0002-7259-1757 ; 0000-0002-5998-9605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666013/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666013/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><contributor>Cohen, Guy</contributor><contributor>Guy Cohen</contributor><creatorcontrib>Shin, Min-Ji</creatorcontrib><creatorcontrib>Chae, Hae-Jung</creatorcontrib><creatorcontrib>Lee, Ji Won</creatorcontrib><creatorcontrib>Koo, Man Hyung</creatorcontrib><creatorcontrib>Kim, Hyun-Jin</creatorcontrib><creatorcontrib>Seo, Jong Bae</creatorcontrib><creatorcontrib>yanIllia, Shagin</creatorcontrib><creatorcontrib>Park, Sang Hee</creatorcontrib><creatorcontrib>Lo, Han En</creatorcontrib><creatorcontrib>Kim, Sung-Hak</creatorcontrib><creatorcontrib>Youn, Ui Joung</creatorcontrib><creatorcontrib>Jeon, Young-Jun</creatorcontrib><creatorcontrib>Suh, Sung-Suk</creatorcontrib><title>Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer</title><title>Evidence-based complementary and alternative medicine</title><description>Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been recognized as an organism that suppresses tumors and inflammation; however, the molecular mechanisms induced by a triterpenoid in Ganoderma lucidum, Lucidumol A, have not yet been fully explored in CRC and inflammatory responses. To this end, we extracted Lucidumol A from Ganoderma lucidum and analyzed its anticancer effect and anti-inflammatory potential in CRC cell lines and RAW264.7 macrophage-derived cell lines, respectively. A series of in vitro experiments including cell survival, wound healing, and migration assays were performed to determine the role of Lucidumol A in the CRC cell line. We also analyzed inflammatory responses using qRT-PCR, Western Blot, and ELISA in RAW 264.7 macrophaged-derived cell lines exposed to various concentrations of Lucidumol A. Lucidumol A efficiently suppressed the metastatic potential of CRC at very low concentrations. Furthermore, significant anti-inflammatory activities were observed in Lucidumol A-treated RAW264.7 cells through modulation of inflammation-associated marker genes and cytokines. In conclusion, Lucidumol A plays an important role in Ganoderma lucidum-dependent tumor suppression and anti-inflammation, suggesting different strategies to treat CRC patients, and other diseases evoked by proinflammatory cytokines, despite the need to explore further its mechanism of action.</description><subject>Antifungal agents</subject><subject>Cell culture</subject><subject>Cell survival</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Flow cytometry</subject><subject>Ganoderma lucidum</subject><subject>Immunotherapy</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>Leukocyte migration</subject><subject>Macrophages</subject><subject>Manufacturers</subject><subject>Metastases</subject><subject>Molecular modelling</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Proteins</subject><subject>Solvents</subject><subject>Statistical analysis</subject><subject>Tumor suppression</subject><subject>Tumors</subject><subject>Wound healing</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kcFq3DAQhk1oIWnSWx9A0Esgu40kS5Z1CSzONg0sNIQWehNjWeoqyNJGspPuI_St6-0ugfTQ0wzMN__Mz18UHwj-RAjnlxRTeikYZkyWR8UJEYzMGa3rNy-9-HFcvMv5AWMqhRAnxe_VqF039tGjxQzdjclZZzp07ZLRg98im2KPbiDEzqQekN_TM7T8tXatGzJahMFpCNoktLR2WkIQOtQY70cPCd0G66HvYYhpi-5N3sSQDXIBNdHH3Q3wqPm7fla8teCzeX-op8X3z8tvzZf56uvNbbNYzXVZ02FuJJaaloTJumNcUsJYOZ3FLW9lLalksgMMlLSCADeYEGaAg-WWCVFXRJSnxdVedzO2vem0CUMCrzbJ9ZC2KoJTryfBrdXP-KRkVVWYlJPA-UEgxcfR5EH1LuvJMAQTx6yoKGsiS8qrCf34D_oQxxQmeztKSI4p5hM121M6xZyTsS_PEKx2wapdsOoQ7IRf7PG1Cx08u__TfwD5RaPf</recordid><startdate>20221108</startdate><enddate>20221108</enddate><creator>Shin, Min-Ji</creator><creator>Chae, Hae-Jung</creator><creator>Lee, Ji Won</creator><creator>Koo, Man Hyung</creator><creator>Kim, Hyun-Jin</creator><creator>Seo, Jong Bae</creator><creator>yanIllia, Shagin</creator><creator>Park, Sang Hee</creator><creator>Lo, Han En</creator><creator>Kim, Sung-Hak</creator><creator>Youn, Ui Joung</creator><creator>Jeon, Young-Jun</creator><creator>Suh, Sung-Suk</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7259-1757</orcidid><orcidid>https://orcid.org/0000-0002-5998-9605</orcidid></search><sort><creationdate>20221108</creationdate><title>Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer</title><author>Shin, Min-Ji ; Chae, Hae-Jung ; Lee, Ji Won ; Koo, Man Hyung ; Kim, Hyun-Jin ; Seo, Jong Bae ; yanIllia, Shagin ; Park, Sang Hee ; Lo, Han En ; Kim, Sung-Hak ; Youn, Ui Joung ; Jeon, Young-Jun ; Suh, Sung-Suk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-e909c231498d45921443fec0b5b9892949da0a21b71a5e0114ea5af5f47786173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antifungal agents</topic><topic>Cell culture</topic><topic>Cell survival</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Flow cytometry</topic><topic>Ganoderma lucidum</topic><topic>Immunotherapy</topic><topic>Inflammation</topic><topic>Kinases</topic><topic>Leukocyte migration</topic><topic>Macrophages</topic><topic>Manufacturers</topic><topic>Metastases</topic><topic>Molecular modelling</topic><topic>Morphology</topic><topic>Mutation</topic><topic>Proteins</topic><topic>Solvents</topic><topic>Statistical analysis</topic><topic>Tumor suppression</topic><topic>Tumors</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Min-Ji</creatorcontrib><creatorcontrib>Chae, Hae-Jung</creatorcontrib><creatorcontrib>Lee, Ji Won</creatorcontrib><creatorcontrib>Koo, Man Hyung</creatorcontrib><creatorcontrib>Kim, Hyun-Jin</creatorcontrib><creatorcontrib>Seo, Jong Bae</creatorcontrib><creatorcontrib>yanIllia, Shagin</creatorcontrib><creatorcontrib>Park, Sang Hee</creatorcontrib><creatorcontrib>Lo, Han En</creatorcontrib><creatorcontrib>Kim, Sung-Hak</creatorcontrib><creatorcontrib>Youn, Ui Joung</creatorcontrib><creatorcontrib>Jeon, Young-Jun</creatorcontrib><creatorcontrib>Suh, Sung-Suk</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Min-Ji</au><au>Chae, Hae-Jung</au><au>Lee, Ji Won</au><au>Koo, Man Hyung</au><au>Kim, Hyun-Jin</au><au>Seo, Jong Bae</au><au>yanIllia, Shagin</au><au>Park, Sang Hee</au><au>Lo, Han En</au><au>Kim, Sung-Hak</au><au>Youn, Ui Joung</au><au>Jeon, Young-Jun</au><au>Suh, Sung-Suk</au><au>Cohen, Guy</au><au>Guy Cohen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2022-11-08</date><risdate>2022</risdate><volume>2022</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy. Ganoderma lucidum has been recognized as an organism that suppresses tumors and inflammation; however, the molecular mechanisms induced by a triterpenoid in Ganoderma lucidum, Lucidumol A, have not yet been fully explored in CRC and inflammatory responses. To this end, we extracted Lucidumol A from Ganoderma lucidum and analyzed its anticancer effect and anti-inflammatory potential in CRC cell lines and RAW264.7 macrophage-derived cell lines, respectively. A series of in vitro experiments including cell survival, wound healing, and migration assays were performed to determine the role of Lucidumol A in the CRC cell line. We also analyzed inflammatory responses using qRT-PCR, Western Blot, and ELISA in RAW 264.7 macrophaged-derived cell lines exposed to various concentrations of Lucidumol A. Lucidumol A efficiently suppressed the metastatic potential of CRC at very low concentrations. Furthermore, significant anti-inflammatory activities were observed in Lucidumol A-treated RAW264.7 cells through modulation of inflammation-associated marker genes and cytokines. In conclusion, Lucidumol A plays an important role in Ganoderma lucidum-dependent tumor suppression and anti-inflammation, suggesting different strategies to treat CRC patients, and other diseases evoked by proinflammatory cytokines, despite the need to explore further its mechanism of action.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2022/7404493</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7259-1757</orcidid><orcidid>https://orcid.org/0000-0002-5998-9605</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2022-11, Vol.2022, p.1-9 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9666013 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Antifungal agents Cell culture Cell survival Chemotherapy Colorectal cancer Colorectal carcinoma Cytokines Cytotoxicity Enzyme-linked immunosorbent assay Flow cytometry Ganoderma lucidum Immunotherapy Inflammation Kinases Leukocyte migration Macrophages Manufacturers Metastases Molecular modelling Morphology Mutation Proteins Solvents Statistical analysis Tumor suppression Tumors Wound healing |
| title | Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T20%3A35%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lucidumol%20A,%20Purified%20Directly%20from%20Ganoderma%20lucidum,%20Exhibits%20Anticancer%20Effect%20and%20Cellular%20Inflammatory%20Response%20in%20Colorectal%20Cancer&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Shin,%20Min-Ji&rft.date=2022-11-08&rft.volume=2022&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2022/7404493&rft_dat=%3Cproquest_pubme%3E2738193256%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2737950205&rft_id=info:pmid/&rfr_iscdi=true |