Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8 memory cytotoxic T cells, is only partly understood. The role of deregulated methylation in T-LGLL is not well known. We analyzed the epig...

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Veröffentlicht in:	Clinical epigenetics 2022-11, Vol.14 (1), p.148-148, Article 148
Hauptverfasser:	Johansson, Patricia, Laguna, Teresa, Ossowski, Julio, Pancaldi, Vera, Brauser, Martina, Dührsen, Ulrich, Keuneke, Lara, Queiros, Ana, Richter, Julia, Martín-Subero, José I, Siebert, Reiner, Schlegelberger, Brigitte, Küppers, Ralf, Dürig, Jan, Murga Penas, Eva M, Carillo-de Santa Pau, Enrique, Bergmann, Anke K
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Biomarkers Biomarkers - metabolism Biotechnology industry Bone marrow CD8 antigen Chromatin Comparative analysis Computer Science CpG islands Cytotoxicity DNA fingerprinting DNA Methylation Epigenetic inheritance Epigenetics Epigenome Gene expression Genes Genomes Humans Immunological memory Information management Leukemia Leukemia, Large Granular Lymphocytic - genetics Leukemia, Large Granular Lymphocytic - metabolism Leukemia, Large Granular Lymphocytic - pathology Life Sciences Lymphatic leukemia Lymphocytes Lymphocytes T Lymphocytic leukemia Memory cells Methylation Mutation Pathogenesis Patients Repressor Proteins - genetics Segmentation T cell receptors T cells Transcription Factors - genetics Tumor Suppressor Proteins - genetics
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