Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL

Cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex CRL4CRBN, is the target of the small molecules lenalidomide and avadomide. Upon binding of the drugs, Aiolos and Ikaros are recruited to the E3 ligase, ubiquitylated, and subsequently degraded. In diffuse large B-cell lymphoma...

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Veröffentlicht in:	Clinical cancer research 2022-08, Vol.28 (15), p.3367-3377
Hauptverfasser:	Hagner, Patrick R, Chiu, Hsiling, Chopra, Vivek S, Colombo, Martino, Patel, Nisha, Estevez, Maria Ortiz, Waldman, Michelle F, Loos, Remco, Towfic, Fadi, Gandhi, Anita K
Format:	Artikel
Sprache:	eng
Schlagworte:	Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Humans Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism Immunologic Factors - therapeutic use Lenalidomide - pharmacology Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Translational Cancer Mechanisms and Therapy Ubiquitin-Protein Ligases - genetics
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