TMET-25. MEK/ERK AND AMPK SIGNALING DICTATE VULNERABILITY TO FATTY ACID DESATURATION INHIBITION IN GLIOBLASTOMA

Lipid metabolism is altered in many cancers. Glioma stem cells (GSCs), a subpopulation that contributes to molecular heterogeneity and therapeutic resistance of glioblastoma (GBM), are highly dependent on de novo lipid synthesis (DNLS) for energy production and proliferation. Although DNLS is a prom...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2022-11, Vol.24 (Supplement_7), p.vii267-vii267
Hauptverfasser:	Sammarco, Alessandro, Eyme, Katharina, Jha, Roshani, Mnatsakanyan, Hayk, Neustadt, Rudolph, Moses, Charlotte, Alnasser, Ahmad, Tardiff, Daniel, Su, Baolong, Williams, Kevin, Bensinger, Steven J, Chung, Chee Yeun, Badr, Christian E
Format:	Artikel
Sprache:	eng
Schlagworte:	Tumor Metabolism
Online-Zugang:	Volltext
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