External contamination of antineoplastic drug vials: an occupational risk to consider

Risk management for workers involved in the handling and preparation of cytotoxic drugs is challenging. This study aims to investigate drug contamination of the exterior surfaces of cytotoxic drug vials. Two batches of commercially available cytotoxic drugs in unprotected vials (ifosfamide, etoposid...

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Veröffentlicht in:European journal of hospital pharmacy. Science and practice 2022-09, Vol.29 (5), p.284-286
Hauptverfasser: Cotteret, Camille, Secretan, Philippe-Henri, Gilles-Afchain, Laurence, Rousseau, Julia, Vidal, Fabrice, Salguero-Hernandez, Gabriel, Batista, Jonathan, Valverde, Vicky, Guitton, Jerome, Cisternino, Salvatore, Schlatter, Joël
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container_end_page 286
container_issue 5
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container_title European journal of hospital pharmacy. Science and practice
container_volume 29
creator Cotteret, Camille
Secretan, Philippe-Henri
Gilles-Afchain, Laurence
Rousseau, Julia
Vidal, Fabrice
Salguero-Hernandez, Gabriel
Batista, Jonathan
Valverde, Vicky
Guitton, Jerome
Cisternino, Salvatore
Schlatter, Joël
description Risk management for workers involved in the handling and preparation of cytotoxic drugs is challenging. This study aims to investigate drug contamination of the exterior surfaces of cytotoxic drug vials. Two batches of commercially available cytotoxic drugs in unprotected vials (ifosfamide, etoposide phosphate and cyclophosphamide) and plastic shrink wrap vials (doxorubicin, cytarabine and busulfan) were tested without removing the flip-off cap or the plastic wrap, and without prewashing. The results showed significant trace amounts of cytotoxic drugs on the exterior surfaces in both unprotected (eg, cyclophosphamide, ifosfamide) and protected plastic shrink wrap vials (eg, cytarabine), indicating that the secondary packaging of protected vials does not systematically prevent exposure to the handlers. These results focus on the need for guidelines to prevent cytotoxic vial contamination and safety recommendations for staff in the handling and storage of these vials.
doi_str_mv 10.1136/ejhpharm-2020-002440
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subjects antineoplastic agents
Cellulose
chemical safety
controlled
Cytotoxicity
Drugs
environment
occupational medicine
Pharmaceutical industry
safety
Short Report
Stem cell transplantation
title External contamination of antineoplastic drug vials: an occupational risk to consider
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