Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine

New vaccines against tuberculosis are urgently required because of the impressive incidence of this disease worldwide and the highly variable protective efficacy of the current vaccine. The possibility of creating new live vaccines by the rational attenuation of strains from the Mycobacterium tuberc...

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Veröffentlicht in:	Infection and immunity 1999-06, Vol.67 (6), p.2867-2873
Hauptverfasser:	JACKSON, M, PHALEN, S. W, LAGRANDERIE, M, ENSERGUEIX, D, CHAVAROT, P, MARCHAL, G, MCMURRAY, D. N, GICQUEL, B, GUILHOT, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacterial Proteins - immunology Bacteriology BCG Vaccine - genetics BCG Vaccine - immunology Biological and medical sciences Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Guinea Pigs Hypersensitivity, Delayed - immunology Macrophages - microbiology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbial Immunity and Vaccines Microbiology Mutagenesis Mycobacterium bovis - genetics Mycobacterium bovis - growth & development Mycobacterium bovis - immunology Mycobacterium bovis - pathogenicity Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Peptide Synthases Purines Tuberculosis - microbiology Tuberculosis - prevention & control Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology
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