Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review
The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinica...
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| Veröffentlicht in: | International journal of environmental research and public health 2022-10, Vol.19 (21), p.14085 |
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| creator | Moaven, Haniyeh Giacaman, Annesi Beltrán, Víctor Sam, Ye Han Betancur, Daniel Mainas, Giuseppe Tarjomani, Seyed Ali Donos, Nikolaos Sousa, Vanessa |
| description | The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1β and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-α reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain
(EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months. |
| doi_str_mv | 10.3390/ijerph192114085 |
| format | Article |
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(EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph192114085</identifier><identifier>PMID: 36360962</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anti-Infective Agents - therapeutic use ; Antimicrobial agents ; Biomarkers ; Chemokines ; Clinical trials ; Cytokines ; Debridement ; Dental implants ; Disease ; Health services ; Humans ; Inflammation ; Interleukin 10 ; Lasers ; Ligands ; Literature reviews ; Matrix metalloproteinase ; Matrix metalloproteinases ; Metalloproteinase ; Minocycline ; Mucositis ; Neutrophil collagenase ; Patients ; Peri-Implantitis - therapy ; Photodynamic therapy ; Prostheses ; Surgery ; Systematic Review ; Tumor necrosis factor-α ; Tumors</subject><ispartof>International journal of environmental research and public health, 2022-10, Vol.19 (21), p.14085</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-a231f304cc51610aaa464e4cf409a45df40fe7e220efd27207b4807389dfa8503</citedby><cites>FETCH-LOGICAL-c421t-a231f304cc51610aaa464e4cf409a45df40fe7e220efd27207b4807389dfa8503</cites><orcidid>0000-0002-2778-9756 ; 0000-0003-3772-3221 ; 0000-0002-4117-9073 ; 0000-0002-8854-9975 ; 0000-0001-8538-694X ; 0000-0002-7748-8580 ; 0000-0001-6046-821X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659150/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659150/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36360962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moaven, Haniyeh</creatorcontrib><creatorcontrib>Giacaman, Annesi</creatorcontrib><creatorcontrib>Beltrán, Víctor</creatorcontrib><creatorcontrib>Sam, Ye Han</creatorcontrib><creatorcontrib>Betancur, Daniel</creatorcontrib><creatorcontrib>Mainas, Giuseppe</creatorcontrib><creatorcontrib>Tarjomani, Seyed Ali</creatorcontrib><creatorcontrib>Donos, Nikolaos</creatorcontrib><creatorcontrib>Sousa, Vanessa</creatorcontrib><title>Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1β and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-α reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain
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We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1β and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-α reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain
(EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36360962</pmid><doi>10.3390/ijerph192114085</doi><orcidid>https://orcid.org/0000-0002-2778-9756</orcidid><orcidid>https://orcid.org/0000-0003-3772-3221</orcidid><orcidid>https://orcid.org/0000-0002-4117-9073</orcidid><orcidid>https://orcid.org/0000-0002-8854-9975</orcidid><orcidid>https://orcid.org/0000-0001-8538-694X</orcidid><orcidid>https://orcid.org/0000-0002-7748-8580</orcidid><orcidid>https://orcid.org/0000-0001-6046-821X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Infective Agents - therapeutic use Antimicrobial agents Biomarkers Chemokines Clinical trials Cytokines Debridement Dental implants Disease Health services Humans Inflammation Interleukin 10 Lasers Ligands Literature reviews Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase Minocycline Mucositis Neutrophil collagenase Patients Peri-Implantitis - therapy Photodynamic therapy Prostheses Surgery Systematic Review Tumor necrosis factor-α Tumors |
| title | Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review |
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