Contribution of Capillary Zone Electrophoresis Hyphenated with Drift Tube Ion Mobility Mass Spectrometry as a Complementary Tool to Microfluidic Reversed Phase Liquid Chromatography for Antigen Discovery

The discovery of new antigens specific to multiple myeloma that could be targeted by novel immunotherapeutic approaches is currently of great interest. To this end, it is important to increase the number of proteins identified in the sample by combining different separation strategies. A capillary z...

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Veröffentlicht in:	International journal of molecular sciences 2022-11, Vol.23 (21), p.13350
Hauptverfasser:	Gou, Marie-Jia, Kose, Murat Cem, Crommen, Jacques, Nix, Cindy, Cobraiville, Gael, Caers, Jo, Fillet, Marianne
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Blood vessels Capillary electrophoresis Capillary tubes capillary zone electrophoresis mass spectrometry Cell Line, Tumor Chromatography Chromatography, Reverse-Phase Data acquisition drift tube ion mobility spectrometry Drift tubes E coli Efficiency Electrophoresis Electrophoresis, Capillary/methods Electrophoretic mobility Hematology Human health sciences Humans Hématologie Identification Ionic mobility Ions Liquid chromatography Mass spectrometry Mass spectroscopy Microfluidics Multiple Myeloma Orthogonality Peptides Physicochemical properties Polyvinyl alcohol Proteins Proteomics Quadrupoles Sciences de la santé humaine Scientific imaging Spectroscopy Tandem Mass Spectrometry/methods untargeted proteomics
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