Impact of Microscopic Confirmation on Therapeutic Management of Pancreatic Cancer Patients: Lessons from an Italian Regional Tumor Registry
Background: Incidence of pancreatic cancer (PC) is increasing worldwide and is set to become the second leading cause of cancer-related death in 2040 with a poor 5-year overall survival (OS). The aim of this study was to analyze the impact of microscopic diagnosis of PC (MiDPC) on diagnostic−therape...
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| Veröffentlicht in: | Cancers 2022-10, Vol.14 (21), p.5372 |
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| creator | Fantin, Alberto Gruppo, Mario De Simoni, Ottavia Lonardi, Sara Cristofori, Chiara Morbin, Tiziana Peserico, Giulia Grillo, Sabina Masier, Annalisa Franco, Monica Pilati, Pierluigi Guzzinati, Stefano Zorzi, Manuel Rugge, Massimo |
| description | Background: Incidence of pancreatic cancer (PC) is increasing worldwide and is set to become the second leading cause of cancer-related death in 2040 with a poor 5-year overall survival (OS). The aim of this study was to analyze the impact of microscopic diagnosis of PC (MiDPC) on diagnostic−therapeutic management and outcome. Methods: The Veneto region (north-eastern Italy) has been covered by a cancer registry (CR) since 1987. Clinical and oncological data about all cases of PC in the Veneto region from 1987 were extracted from the Veneto CR database. Results: In 2018, 1340 incident cases of PC in the Veneto population were registered (4.1% of all malignant tumors), with an increasing trend in females and stable incidence in males. Five-year OS in patients with PC was 8%. The percentage of MiDPC increased from 44% in 2010 to 60% in 2018 (p = 0.001). MiDPC was higher among patients aged < 75 years old (84.4%) compared to those aged ≥75 years old (38.9%), p = 0.001. Between 2010 and 2018, a significant increase in biopsy on the primary neoplasm (24.9% vs. 13%, p < 0.001) was reported. Patients with MiDPC had higher 5-year survival than patients with no MiDPC (12.9% vs. 1.2%, p < 0.001). Conclusions: The implementation of MiDPC was essential to improve diagnostic−therapeutic pathways and consequently the survival of PC patients. |
| doi_str_mv | 10.3390/cancers14215372 |
| format | Article |
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The aim of this study was to analyze the impact of microscopic diagnosis of PC (MiDPC) on diagnostic−therapeutic management and outcome. Methods: The Veneto region (north-eastern Italy) has been covered by a cancer registry (CR) since 1987. Clinical and oncological data about all cases of PC in the Veneto region from 1987 were extracted from the Veneto CR database. Results: In 2018, 1340 incident cases of PC in the Veneto population were registered (4.1% of all malignant tumors), with an increasing trend in females and stable incidence in males. Five-year OS in patients with PC was 8%. The percentage of MiDPC increased from 44% in 2010 to 60% in 2018 (p = 0.001). MiDPC was higher among patients aged < 75 years old (84.4%) compared to those aged ≥75 years old (38.9%), p = 0.001. Between 2010 and 2018, a significant increase in biopsy on the primary neoplasm (24.9% vs. 13%, p < 0.001) was reported. Patients with MiDPC had higher 5-year survival than patients with no MiDPC (12.9% vs. 1.2%, p < 0.001). Conclusions: The implementation of MiDPC was essential to improve diagnostic−therapeutic pathways and consequently the survival of PC patients.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14215372</identifier><identifier>PMID: 36358790</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biopsy ; Care and treatment ; Chemotherapy ; Diagnosis ; Disease management ; Endoscopy ; Hospitals ; Metastasis ; Microscope and microscopy ; Mortality ; Pancreatic cancer ; Patients ; Population ; Surgery ; Survival ; Trends ; Tumors</subject><ispartof>Cancers, 2022-10, Vol.14 (21), p.5372</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c442t-cf605ee65a1f781d9686dd51a113cd2f76c61e85a72d9c14df56fb606613a8223</cites><orcidid>0000-0002-7593-8138 ; 0000-0001-8788-5590 ; 0000-0002-4908-5506 ; 0000-0001-5525-5762</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658973/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658973/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36358790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fantin, Alberto</creatorcontrib><creatorcontrib>Gruppo, Mario</creatorcontrib><creatorcontrib>De Simoni, Ottavia</creatorcontrib><creatorcontrib>Lonardi, Sara</creatorcontrib><creatorcontrib>Cristofori, Chiara</creatorcontrib><creatorcontrib>Morbin, Tiziana</creatorcontrib><creatorcontrib>Peserico, Giulia</creatorcontrib><creatorcontrib>Grillo, Sabina</creatorcontrib><creatorcontrib>Masier, Annalisa</creatorcontrib><creatorcontrib>Franco, Monica</creatorcontrib><creatorcontrib>Pilati, Pierluigi</creatorcontrib><creatorcontrib>Guzzinati, Stefano</creatorcontrib><creatorcontrib>Zorzi, Manuel</creatorcontrib><creatorcontrib>Rugge, Massimo</creatorcontrib><title>Impact of Microscopic Confirmation on Therapeutic Management of Pancreatic Cancer Patients: Lessons from an Italian Regional Tumor Registry</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Background: Incidence of pancreatic cancer (PC) is increasing worldwide and is set to become the second leading cause of cancer-related death in 2040 with a poor 5-year overall survival (OS). The aim of this study was to analyze the impact of microscopic diagnosis of PC (MiDPC) on diagnostic−therapeutic management and outcome. Methods: The Veneto region (north-eastern Italy) has been covered by a cancer registry (CR) since 1987. Clinical and oncological data about all cases of PC in the Veneto region from 1987 were extracted from the Veneto CR database. Results: In 2018, 1340 incident cases of PC in the Veneto population were registered (4.1% of all malignant tumors), with an increasing trend in females and stable incidence in males. Five-year OS in patients with PC was 8%. The percentage of MiDPC increased from 44% in 2010 to 60% in 2018 (p = 0.001). MiDPC was higher among patients aged < 75 years old (84.4%) compared to those aged ≥75 years old (38.9%), p = 0.001. Between 2010 and 2018, a significant increase in biopsy on the primary neoplasm (24.9% vs. 13%, p < 0.001) was reported. Patients with MiDPC had higher 5-year survival than patients with no MiDPC (12.9% vs. 1.2%, p < 0.001). Conclusions: The implementation of MiDPC was essential to improve diagnostic−therapeutic pathways and consequently the survival of PC patients.</description><subject>Biopsy</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Disease management</subject><subject>Endoscopy</subject><subject>Hospitals</subject><subject>Metastasis</subject><subject>Microscope and microscopy</subject><subject>Mortality</subject><subject>Pancreatic cancer</subject><subject>Patients</subject><subject>Population</subject><subject>Surgery</subject><subject>Survival</subject><subject>Trends</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUk1v1DAQjRCIVqVnbigSFy7bxh8ZJxyQqhUtK20FQsvZmjrjravEDnaC1N_An8a7LaWtsC2NPe_N83g8RfGWVSdCtNWpQW8oJiY5q4XiL4pDXim-AGjly0f7g-I4pZsqDyGYAvW6OBAg6ka11WHxezWMaKYy2PLSmRiSCaMz5TJ46-KAkwu-zGtzTRFHmqeMXaLHLQ3k91HfchKRcAcs9_lkz-QymD6Wa0op-FTaGIYSfbmasHfZfqdt1sW-3MxDiPtjmuLtm-KVxT7R8b09Kn6cf94svyzWXy9Wy7P1wkjJp4WxUNVEUCOzqmFdCw10Xc2QMWE6bhUYYNTUqHjXGiY7W4O9ggqACWw4F0fFpzvdcb4aqDM52Yi9HqMbMN7qgE4_Rby71tvwS7dQN60SWeDDvUAMP2dKkx5cMtT36CnMSXOVy9sK4DJT3z-j3oQ55rfvWRKYZBL-sbbYk3behnyv2YnqMyVrrjhUO62T_7Dy7GhwJniyLvufBJzeBew-NkWyD29kld61kH7WQjni3ePSPPD_Noz4AyUfw_Y</recordid><startdate>20221031</startdate><enddate>20221031</enddate><creator>Fantin, Alberto</creator><creator>Gruppo, Mario</creator><creator>De Simoni, Ottavia</creator><creator>Lonardi, Sara</creator><creator>Cristofori, Chiara</creator><creator>Morbin, Tiziana</creator><creator>Peserico, Giulia</creator><creator>Grillo, Sabina</creator><creator>Masier, Annalisa</creator><creator>Franco, Monica</creator><creator>Pilati, Pierluigi</creator><creator>Guzzinati, Stefano</creator><creator>Zorzi, Manuel</creator><creator>Rugge, Massimo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7593-8138</orcidid><orcidid>https://orcid.org/0000-0001-8788-5590</orcidid><orcidid>https://orcid.org/0000-0002-4908-5506</orcidid><orcidid>https://orcid.org/0000-0001-5525-5762</orcidid></search><sort><creationdate>20221031</creationdate><title>Impact of Microscopic Confirmation on Therapeutic Management of Pancreatic Cancer Patients: Lessons from an Italian Regional Tumor Registry</title><author>Fantin, Alberto ; Gruppo, Mario ; De Simoni, Ottavia ; Lonardi, Sara ; Cristofori, Chiara ; Morbin, Tiziana ; Peserico, Giulia ; Grillo, Sabina ; Masier, Annalisa ; Franco, Monica ; Pilati, Pierluigi ; Guzzinati, Stefano ; Zorzi, Manuel ; Rugge, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-cf605ee65a1f781d9686dd51a113cd2f76c61e85a72d9c14df56fb606613a8223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biopsy</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Diagnosis</topic><topic>Disease management</topic><topic>Endoscopy</topic><topic>Hospitals</topic><topic>Metastasis</topic><topic>Microscope and microscopy</topic><topic>Mortality</topic><topic>Pancreatic cancer</topic><topic>Patients</topic><topic>Population</topic><topic>Surgery</topic><topic>Survival</topic><topic>Trends</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fantin, Alberto</creatorcontrib><creatorcontrib>Gruppo, Mario</creatorcontrib><creatorcontrib>De Simoni, Ottavia</creatorcontrib><creatorcontrib>Lonardi, Sara</creatorcontrib><creatorcontrib>Cristofori, Chiara</creatorcontrib><creatorcontrib>Morbin, Tiziana</creatorcontrib><creatorcontrib>Peserico, Giulia</creatorcontrib><creatorcontrib>Grillo, Sabina</creatorcontrib><creatorcontrib>Masier, Annalisa</creatorcontrib><creatorcontrib>Franco, Monica</creatorcontrib><creatorcontrib>Pilati, Pierluigi</creatorcontrib><creatorcontrib>Guzzinati, Stefano</creatorcontrib><creatorcontrib>Zorzi, Manuel</creatorcontrib><creatorcontrib>Rugge, Massimo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fantin, Alberto</au><au>Gruppo, Mario</au><au>De Simoni, Ottavia</au><au>Lonardi, Sara</au><au>Cristofori, Chiara</au><au>Morbin, Tiziana</au><au>Peserico, Giulia</au><au>Grillo, Sabina</au><au>Masier, Annalisa</au><au>Franco, Monica</au><au>Pilati, Pierluigi</au><au>Guzzinati, Stefano</au><au>Zorzi, Manuel</au><au>Rugge, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Microscopic Confirmation on Therapeutic Management of Pancreatic Cancer Patients: Lessons from an Italian Regional Tumor Registry</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2022-10-31</date><risdate>2022</risdate><volume>14</volume><issue>21</issue><spage>5372</spage><pages>5372-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Background: Incidence of pancreatic cancer (PC) is increasing worldwide and is set to become the second leading cause of cancer-related death in 2040 with a poor 5-year overall survival (OS). The aim of this study was to analyze the impact of microscopic diagnosis of PC (MiDPC) on diagnostic−therapeutic management and outcome. Methods: The Veneto region (north-eastern Italy) has been covered by a cancer registry (CR) since 1987. Clinical and oncological data about all cases of PC in the Veneto region from 1987 were extracted from the Veneto CR database. Results: In 2018, 1340 incident cases of PC in the Veneto population were registered (4.1% of all malignant tumors), with an increasing trend in females and stable incidence in males. Five-year OS in patients with PC was 8%. The percentage of MiDPC increased from 44% in 2010 to 60% in 2018 (p = 0.001). MiDPC was higher among patients aged < 75 years old (84.4%) compared to those aged ≥75 years old (38.9%), p = 0.001. Between 2010 and 2018, a significant increase in biopsy on the primary neoplasm (24.9% vs. 13%, p < 0.001) was reported. Patients with MiDPC had higher 5-year survival than patients with no MiDPC (12.9% vs. 1.2%, p < 0.001). Conclusions: The implementation of MiDPC was essential to improve diagnostic−therapeutic pathways and consequently the survival of PC patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36358790</pmid><doi>10.3390/cancers14215372</doi><orcidid>https://orcid.org/0000-0002-7593-8138</orcidid><orcidid>https://orcid.org/0000-0001-8788-5590</orcidid><orcidid>https://orcid.org/0000-0002-4908-5506</orcidid><orcidid>https://orcid.org/0000-0001-5525-5762</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biopsy Care and treatment Chemotherapy Diagnosis Disease management Endoscopy Hospitals Metastasis Microscope and microscopy Mortality Pancreatic cancer Patients Population Surgery Survival Trends Tumors |
| title | Impact of Microscopic Confirmation on Therapeutic Management of Pancreatic Cancer Patients: Lessons from an Italian Regional Tumor Registry |
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