Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome
Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body,...
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| Veröffentlicht in: | Nutrients 2022-11, Vol.14 (21), p.4660 |
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| creator | Bettag, Jeffery Po, Loren Cunningham, Cassius Tallam, Rahul Kurashima, Kento Nagarapu, Aakash Hutchinson, Chelsea Morfin, Sylvia Nazzal, Mustafa Lin, Chien-Jung Mathur, Amit Aurora, Rajeev Jain, Ajay K |
| description | Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut-brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury. |
| doi_str_mv | 10.3390/nu14214660 |
| format | Article |
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Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut-brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14214660</identifier><identifier>PMID: 36364922</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acids ; Amino acids ; Animals ; Atrophy ; Bile ; Biological effects ; Care and treatment ; Cell growth ; Complications ; Complications and side effects ; Development and progression ; Digestive system ; Disease Models, Animal ; Enteral nutrition ; Glucagon ; Glucose ; Growth factors ; Hormones ; Humans ; Intestine ; Intestine, Small - metabolism ; Intravenous administration ; Liver ; Liver - metabolism ; Liver diseases ; Malabsorption syndromes ; Medical prognosis ; Metabolism ; Microbiota ; Nutrients ; Nutrition ; Parenteral feeding ; Parenteral nutrition ; Parenteral Nutrition, Total ; Parenteral therapy ; Parenting ; Peptides ; Physiological aspects ; Physiology ; Prevention ; Requirements ; Review ; Risk factors ; Short bowel syndrome ; Short Bowel Syndrome - complications ; Short Bowel Syndrome - metabolism ; Short Bowel Syndrome - therapy ; Small intestine ; Tumor necrosis factor-TNF</subject><ispartof>Nutrients, 2022-11, Vol.14 (21), p.4660</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut-brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury.</description><subject>Acids</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Bile</subject><subject>Biological effects</subject><subject>Care and treatment</subject><subject>Cell growth</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Digestive system</subject><subject>Disease Models, Animal</subject><subject>Enteral nutrition</subject><subject>Glucagon</subject><subject>Glucose</subject><subject>Growth factors</subject><subject>Hormones</subject><subject>Humans</subject><subject>Intestine</subject><subject>Intestine, Small - metabolism</subject><subject>Intravenous administration</subject><subject>Liver</subject><subject>Liver - 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metabolism</topic><topic>Intravenous administration</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver diseases</topic><topic>Malabsorption syndromes</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Nutrients</topic><topic>Nutrition</topic><topic>Parenteral feeding</topic><topic>Parenteral nutrition</topic><topic>Parenteral Nutrition, Total</topic><topic>Parenteral therapy</topic><topic>Parenting</topic><topic>Peptides</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Prevention</topic><topic>Requirements</topic><topic>Review</topic><topic>Risk factors</topic><topic>Short bowel syndrome</topic><topic>Short Bowel Syndrome - complications</topic><topic>Short Bowel Syndrome - metabolism</topic><topic>Short Bowel Syndrome - therapy</topic><topic>Small intestine</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bettag, Jeffery</creatorcontrib><creatorcontrib>Po, Loren</creatorcontrib><creatorcontrib>Cunningham, Cassius</creatorcontrib><creatorcontrib>Tallam, Rahul</creatorcontrib><creatorcontrib>Kurashima, Kento</creatorcontrib><creatorcontrib>Nagarapu, Aakash</creatorcontrib><creatorcontrib>Hutchinson, Chelsea</creatorcontrib><creatorcontrib>Morfin, Sylvia</creatorcontrib><creatorcontrib>Nazzal, Mustafa</creatorcontrib><creatorcontrib>Lin, Chien-Jung</creatorcontrib><creatorcontrib>Mathur, Amit</creatorcontrib><creatorcontrib>Aurora, Rajeev</creatorcontrib><creatorcontrib>Jain, Ajay K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut-brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36364922</pmid><doi>10.3390/nu14214660</doi><orcidid>https://orcid.org/0000-0002-6609-6055</orcidid><orcidid>https://orcid.org/0000-0003-2712-9499</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Amino acids Animals Atrophy Bile Biological effects Care and treatment Cell growth Complications Complications and side effects Development and progression Digestive system Disease Models, Animal Enteral nutrition Glucagon Glucose Growth factors Hormones Humans Intestine Intestine, Small - metabolism Intravenous administration Liver Liver - metabolism Liver diseases Malabsorption syndromes Medical prognosis Metabolism Microbiota Nutrients Nutrition Parenteral feeding Parenteral nutrition Parenteral Nutrition, Total Parenteral therapy Parenting Peptides Physiological aspects Physiology Prevention Requirements Review Risk factors Short bowel syndrome Short Bowel Syndrome - complications Short Bowel Syndrome - metabolism Short Bowel Syndrome - therapy Small intestine Tumor necrosis factor-TNF |
| title | Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome |
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