Trans-Endothelial Migration of Memory T Cells Is Impaired in Alemtuzumab-Treated Multiple Sclerosis Patients

The breakdown of the blood–brain barrier (BBB) and the trans-endothelial migration of lymphocytes are central events in the development of multiple sclerosis (MS). Autoreactive T cells are major players in MS pathogenesis, which are rapidly depleted following alemtuzumab treatment. This modulation,...

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Veröffentlicht in:	Journal of clinical medicine 2022-10, Vol.11 (21), p.6266
Hauptverfasser:	Nguyen, Kristy, Juillard, Pierre, Hawke, Simon, Grau, Georges E., Marsh-Wakefield, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell adhesion & migration Cell culture Clinical medicine Collagen Lymphocytes Monoclonal antibodies T cell receptors
Online-Zugang:	Volltext
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